Treatment and Management of Autosomal Dominant Polycystic Kidney Disease
Autosomal dominant polycystic kidney disease (ADPKD) is the most common life-threatening single-gene disease. It affects up to 15 million people worldwide with 50% risk for end-stage kidney disease, 80% risk for hypertension, 60% risk for painful kidney complications, 20% risk for symptomatic polycy...
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| Format: | Online |
| Language: | English |
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Exon Publications
2024
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| Online Access: | https://directory.doabooks.org/handle/20.500.12854/136609 |
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| _version_ | 1869513896233009152 |
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| author | Helal, Imed |
| author_browse | Helal, Imed |
| author_facet | Helal, Imed |
| author_sort | Helal, Imed |
| collection | Directory of Open Access Books |
| description | Autosomal dominant polycystic kidney disease (ADPKD) is the most common life-threatening single-gene disease. It affects up to 15 million people worldwide with 50% risk for end-stage kidney disease, 80% risk for hypertension, 60% risk for painful kidney complications, 20% risk for symptomatic polycystic liver disease and 3% risk for intra-cerebral aneurysm rupture. For a long time, the treatment and management strategies of this disease have not progressed in comparison with the treatment of other kidney diseases. Recently, there have been new therapeutic hopes with identification of specific drugs based on the mechanisms of kidney progression. This chapter reviews the treatment and management of ADPKD progression, and the identification of ADPKD patients with rapidly progressing disease, hypertension, and extrarenal complications. |
| format | Online |
| id | doab-20.500.12854ir-136609 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Exon Publications |
| publisherStr | Exon Publications |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1366092024-05-02T05:26:42Z Treatment and Management of Autosomal Dominant Polycystic Kidney Disease Helal, Imed Li, Xiaogang angiotensin II receptor blockers treatment of polycystic kidney disease M Autosomal dominant polycystic kidney disease (ADPKD) is the most common life-threatening single-gene disease. It affects up to 15 million people worldwide with 50% risk for end-stage kidney disease, 80% risk for hypertension, 60% risk for painful kidney complications, 20% risk for symptomatic polycystic liver disease and 3% risk for intra-cerebral aneurysm rupture. For a long time, the treatment and management strategies of this disease have not progressed in comparison with the treatment of other kidney diseases. Recently, there have been new therapeutic hopes with identification of specific drugs based on the mechanisms of kidney progression. This chapter reviews the treatment and management of ADPKD progression, and the identification of ADPKD patients with rapidly progressing disease, hypertension, and extrarenal complications. Published 2024-05-02T05:26:35Z 2024-05-02T05:26:35Z 2015-11-18 chapter https://directory.doabooks.org/handle/20.500.12854/136609 eng image/jpeg Attribution-NonCommercial-NoDerivatives 4.0 International https://exonpublications.com/index.php/exon/article/view/69 Exon Publications 10.15586/codon.pkd.2015.ch3 10.15586/codon.pkd.2015.ch3 2d6001a3-9e06-4979-bf02-6974e313eb24 61-73 Brisbane open access |
| spellingShingle | angiotensin II receptor blockers treatment of polycystic kidney disease M Helal, Imed Treatment and Management of Autosomal Dominant Polycystic Kidney Disease |
| title | Treatment and Management of Autosomal Dominant Polycystic Kidney Disease |
| title_full | Treatment and Management of Autosomal Dominant Polycystic Kidney Disease |
| title_fullStr | Treatment and Management of Autosomal Dominant Polycystic Kidney Disease |
| title_full_unstemmed | Treatment and Management of Autosomal Dominant Polycystic Kidney Disease |
| title_short | Treatment and Management of Autosomal Dominant Polycystic Kidney Disease |
| title_sort | treatment and management of autosomal dominant polycystic kidney disease |
| topic | angiotensin II receptor blockers treatment of polycystic kidney disease M |
| topic_facet | angiotensin II receptor blockers treatment of polycystic kidney disease M |
| url | https://directory.doabooks.org/handle/20.500.12854/136609 |
| work_keys_str_mv | AT helalimed treatmentandmanagementofautosomaldominantpolycystickidneydisease |