Blood Pressure Control for Polycystic Kidney Disease
Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent genetic kidney disease and affects 6 to 12 million patients worldwide. The disease is characterized by the progressive development of innumerable renal cysts that gradually replace normal kidney tissue, leading ultimately to...
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| Materialtyp: | Online |
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| Språk: | engelska |
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Exon Publications
2024
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| Länkar: | https://directory.doabooks.org/handle/20.500.12854/136611 |
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| description | Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent genetic kidney disease and affects 6 to 12 million patients worldwide. The disease is characterized by the progressive development of innumerable renal cysts that gradually replace normal kidney tissue, leading ultimately to the loss of renal function starting from the 5th decade of life. Most patients with ADPKD develop arterial hypertension. High blood pressure develops early in the course of the disease and is caused by the activation of the renin-angiotensin-aldosterone system (RAAS) and other significant pathogenic mechanisms. Hypertension is a major contributing factor for the increased cardiovascular morbidity and mortality in patients with ADPKD. Optimal treatment of hypertension is essential to improve the prognosis of the cystic disease and the associated cardiovascular diseases. Target blood pressures and choice of antihypertensive drugs for patients with ADPKD have not been firmly defined in guidelines, but the recently published results from the HALT-PKD studies suggest that a blood pressure goal of <130/80 mm Hg should be targeted, preferably with inhibitors of the RAAS. |
| format | Online |
| id | doab-20.500.12854ir-136611 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Exon Publications |
| publisherStr | Exon Publications |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1366112024-05-02T05:59:10Z Blood Pressure Control for Polycystic Kidney Disease hypertension, polycystic kidney disease, renin-angiotensin-aldosterone-system M Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent genetic kidney disease and affects 6 to 12 million patients worldwide. The disease is characterized by the progressive development of innumerable renal cysts that gradually replace normal kidney tissue, leading ultimately to the loss of renal function starting from the 5th decade of life. Most patients with ADPKD develop arterial hypertension. High blood pressure develops early in the course of the disease and is caused by the activation of the renin-angiotensin-aldosterone system (RAAS) and other significant pathogenic mechanisms. Hypertension is a major contributing factor for the increased cardiovascular morbidity and mortality in patients with ADPKD. Optimal treatment of hypertension is essential to improve the prognosis of the cystic disease and the associated cardiovascular diseases. Target blood pressures and choice of antihypertensive drugs for patients with ADPKD have not been firmly defined in guidelines, but the recently published results from the HALT-PKD studies suggest that a blood pressure goal of <130/80 mm Hg should be targeted, preferably with inhibitors of the RAAS. Published 2024-05-02T05:59:06Z 2024-05-02T05:59:06Z 2015-11-18 chapter 978-0-9944381-0-2 https://directory.doabooks.org/handle/20.500.12854/136611 eng image/jpeg Attribution-NonCommercial-NoDerivatives 4.0 International https://exonpublications.com/index.php/exon/article/view/71 Exon Publications 10.15586/codon.pkd.2015.ch5 10.15586/codon.pkd.2015.ch5 2d6001a3-9e06-4979-bf02-6974e313eb24 978-0-9944381-0-2 95-108 Brisbane open access |
| spellingShingle | hypertension, polycystic kidney disease, renin-angiotensin-aldosterone-system M Blood Pressure Control for Polycystic Kidney Disease |
| title | Blood Pressure Control for Polycystic Kidney Disease |
| title_full | Blood Pressure Control for Polycystic Kidney Disease |
| title_fullStr | Blood Pressure Control for Polycystic Kidney Disease |
| title_full_unstemmed | Blood Pressure Control for Polycystic Kidney Disease |
| title_short | Blood Pressure Control for Polycystic Kidney Disease |
| title_sort | blood pressure control for polycystic kidney disease |
| topic | hypertension, polycystic kidney disease, renin-angiotensin-aldosterone-system M |
| topic_facet | hypertension, polycystic kidney disease, renin-angiotensin-aldosterone-system M |
| url | https://directory.doabooks.org/handle/20.500.12854/136611 |