MicroRNAs and Polycystic Kidney Disease
MicroRNAs (miRNAs) are a class of small non protein-coding RNAs that function as inhibitors of post-transcriptional gene expression in plants and animals. Over a thousand different miRNAs are known to be encoded by the human genome, the majority of which are conserved in other species. miRNAs are es...
সংরক্ষণ করুন:
| বিন্যাস: | Online |
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| ভাষা: | ইংরেজি |
| প্রকাশিত: |
Exon Publications
2024
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | https://directory.doabooks.org/handle/20.500.12854/136659.2 |
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| collection | Directory of Open Access Books |
| description | MicroRNAs (miRNAs) are a class of small non protein-coding RNAs that function as inhibitors of post-transcriptional gene expression in plants and animals. Over a thousand different miRNAs are known to be encoded by the human genome, the majority of which are conserved in other species. miRNAs are essential for virtually all aspects of mammalian biology, including development of key organs such the brain, the heart, and the kidney. More importantly, miRNAs are implicated in the pathogenesis of numerous common human diseases, and pharmaceutical manipulation of miRNA function has emerged as an exciting new therapeutic approach for cancer and kidney diseases. Several lines of evidence have connected miRNAs to the pathogenesis of polycystic kidney disease (PKD). miRNAs are aberrantly expressed in cystic kidneys and this aberrant expression is thought to regulate key aspects of cyst pathogenesis such as cyst epithelial cell proliferation and apoptosis as well as dosage of the various cystic kidney disease genes. In this chapter, we briefly discuss the basic biology of miRNAs and their role in kidney development, and highlight the role of three miRNA families – miR-17 and related miRNAs, miR-200 family and miR-21- in the pathogenesis of PKD. |
| format | Online |
| id | doab-20.500.12854ir-136659.2 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Exon Publications |
| publisherStr | Exon Publications |
| record_format | ojs |
| spelling | doab-20.500.12854ir-136659.22024-05-02T08:08:59Z MicroRNAs and Polycystic Kidney Disease MicroRNAs, miR-17~92, miR-21, miR-200, polycystic kidney disease M MicroRNAs (miRNAs) are a class of small non protein-coding RNAs that function as inhibitors of post-transcriptional gene expression in plants and animals. Over a thousand different miRNAs are known to be encoded by the human genome, the majority of which are conserved in other species. miRNAs are essential for virtually all aspects of mammalian biology, including development of key organs such the brain, the heart, and the kidney. More importantly, miRNAs are implicated in the pathogenesis of numerous common human diseases, and pharmaceutical manipulation of miRNA function has emerged as an exciting new therapeutic approach for cancer and kidney diseases. Several lines of evidence have connected miRNAs to the pathogenesis of polycystic kidney disease (PKD). miRNAs are aberrantly expressed in cystic kidneys and this aberrant expression is thought to regulate key aspects of cyst pathogenesis such as cyst epithelial cell proliferation and apoptosis as well as dosage of the various cystic kidney disease genes. In this chapter, we briefly discuss the basic biology of miRNAs and their role in kidney development, and highlight the role of three miRNA families – miR-17 and related miRNAs, miR-200 family and miR-21- in the pathogenesis of PKD. Published 2024-05-02T08:08:48Z 2024-05-02T07:59:31Z 2024-05-02T08:08:48Z 2015-11-18 chapter 978-0-9944381-0-2 https://directory.doabooks.org/handle/20.500.12854/136659.2 eng image/jpeg Exon Publications Polycystic Kidney Disease 10.15586/codon.pkd.2015.ch13 10.15586/codon.pkd.2015.ch13 2d6001a3-9e06-4979-bf02-6974e313eb24 01173f6b-d01d-49c3-b18e-93cfe3a0383d 978-0-9944381-0-2 313-334 Brisbane(AU) open access |
| spellingShingle | MicroRNAs, miR-17~92, miR-21, miR-200, polycystic kidney disease M MicroRNAs and Polycystic Kidney Disease |
| title | MicroRNAs and Polycystic Kidney Disease |
| title_full | MicroRNAs and Polycystic Kidney Disease |
| title_fullStr | MicroRNAs and Polycystic Kidney Disease |
| title_full_unstemmed | MicroRNAs and Polycystic Kidney Disease |
| title_short | MicroRNAs and Polycystic Kidney Disease |
| title_sort | micrornas and polycystic kidney disease |
| topic | MicroRNAs, miR-17~92, miR-21, miR-200, polycystic kidney disease M |
| topic_facet | MicroRNAs, miR-17~92, miR-21, miR-200, polycystic kidney disease M |
| url | https://directory.doabooks.org/handle/20.500.12854/136659.2 |