Frontiers in Nucleic Acid Chemistry —in Memory of Professor Enrique Pedroso for His Outstanding Contributions to Nucleic Acid Chemistry
This reprint is dedicated to the memory of Enrique Pedroso, Professor Emeritus of Organic Chemistry at University of Barcelona, who passed away at the age of 72 on September 2020. Professor Enrique Pedroso has been one of the pioneers of Nucleic Acids Chemistry in Spain, significantly contributing t...
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MDPI - Multidisciplinary Digital Publishing Institute
2024
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| Mynediad Ar-lein: | ONIX_20240514_9783036598987_34 |
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Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!
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| collection | Directory of Open Access Books |
| description | This reprint is dedicated to the memory of Enrique Pedroso, Professor Emeritus of Organic Chemistry at University of Barcelona, who passed away at the age of 72 on September 2020. Professor Enrique Pedroso has been one of the pioneers of Nucleic Acids Chemistry in Spain, significantly contributing to the development of this highly interdisciplinary field which combines organic chemistry, biochemistry, pharmacology, materials chemistry, and biophysics. His major research achievements were accomplished in the synthesis of modified oligonucleotides and especially conjugates and cyclic oligonucleotides, as well as their analogues, which opened up new avenues in the search for novel applications of oligonucleotides.This reprint comprises a collection of research or review articles prepared by international experts in Nucleic Acids, including nucleoside and oligonucleotide synthesis, nucleic acids structural studies, DNA repair, and biophysical characterization of DNA-targeting ligands, especially G-quadruplex binding drugs. |
| format | Online |
| id | doab-20.500.12854ir-137432 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1374322024-05-14T13:04:01Z Frontiers in Nucleic Acid Chemistry —in Memory of Professor Enrique Pedroso for His Outstanding Contributions to Nucleic Acid Chemistry Eritja, Ramon Montesarchio, Daniela Terrazas, Montserrat Pu22 G-quadruplex c-myc phytochemicals circular dichroism in silico simulations molecular docking CD prediction N-acetylgalactosamine antisense oligonucleotide conjugates asialoglycoprotein receptor luciferase gene gapmers 2′,3′-dideoxynucleosides 2′,3′-didehydro-2′,3′-dideoxynucleosides synthesis zalcitabine (ddC) didanosine (ddI) stavudine (d4T) PARP1 promoter stabilizing ligand NMR fluorescence molecular modeling DNA structure RNA structure quadruplex tetrad intrinsic fluorescence DNA aptamer binding modified nucleic acids DNA polymerases nucleoside triphosphates primer extension reactions SELEX antimicrobial resistance n/a oligonucleotides DNA recognition chromosomes pyrene FISH karyotyping SNP strand invasion DNA quadruplex duplex-quadruplex equilibrium base excision repair pyridostatin glycosylase telomere 5′-functionalization small molecules conjugates of oligonucleotides solid-phase synthesis pH-sensitive phosphoramidate linkage siRNA phosphorodiamidate morpholinos (PMO) phosphoroamidate morpholinos (MO) thiophosphoramidate morpholinos (TMO) phosphoramidites amyotrophic lateral sclerosis frontotemporal dementia C9orf72 GGGGCC G4 thema EDItEUR::P Mathematics and Science::PN Chemistry::PNK Inorganic chemistry This reprint is dedicated to the memory of Enrique Pedroso, Professor Emeritus of Organic Chemistry at University of Barcelona, who passed away at the age of 72 on September 2020. Professor Enrique Pedroso has been one of the pioneers of Nucleic Acids Chemistry in Spain, significantly contributing to the development of this highly interdisciplinary field which combines organic chemistry, biochemistry, pharmacology, materials chemistry, and biophysics. His major research achievements were accomplished in the synthesis of modified oligonucleotides and especially conjugates and cyclic oligonucleotides, as well as their analogues, which opened up new avenues in the search for novel applications of oligonucleotides.This reprint comprises a collection of research or review articles prepared by international experts in Nucleic Acids, including nucleoside and oligonucleotide synthesis, nucleic acids structural studies, DNA repair, and biophysical characterization of DNA-targeting ligands, especially G-quadruplex binding drugs. 2024-05-14T13:03:53Z 2024-05-14T13:03:53Z 2024 book ONIX_20240514_9783036598987_34 9783036598987 9783036598970 https://directory.doabooks.org/handle/20.500.12854/137432 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/8586 https://mdpi.com/books/pdfview/book/8586 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-9897-0 10.3390/books978-3-0365-9897-0 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036598987 9783036598970 200 open access |
| spellingShingle | Pu22 G-quadruplex c-myc phytochemicals circular dichroism in silico simulations molecular docking CD prediction N-acetylgalactosamine antisense oligonucleotide conjugates asialoglycoprotein receptor luciferase gene gapmers 2′,3′-dideoxynucleosides 2′,3′-didehydro-2′,3′-dideoxynucleosides synthesis zalcitabine (ddC) didanosine (ddI) stavudine (d4T) PARP1 promoter stabilizing ligand NMR fluorescence molecular modeling DNA structure RNA structure quadruplex tetrad intrinsic fluorescence DNA aptamer binding modified nucleic acids DNA polymerases nucleoside triphosphates primer extension reactions SELEX antimicrobial resistance n/a oligonucleotides DNA recognition chromosomes pyrene FISH karyotyping SNP strand invasion DNA quadruplex duplex-quadruplex equilibrium base excision repair pyridostatin glycosylase telomere 5′-functionalization small molecules conjugates of oligonucleotides solid-phase synthesis pH-sensitive phosphoramidate linkage siRNA phosphorodiamidate morpholinos (PMO) phosphoroamidate morpholinos (MO) thiophosphoramidate morpholinos (TMO) phosphoramidites amyotrophic lateral sclerosis frontotemporal dementia C9orf72 GGGGCC G4 thema EDItEUR::P Mathematics and Science::PN Chemistry::PNK Inorganic chemistry Frontiers in Nucleic Acid Chemistry —in Memory of Professor Enrique Pedroso for His Outstanding Contributions to Nucleic Acid Chemistry |
| title | Frontiers in Nucleic Acid Chemistry —in Memory of Professor Enrique Pedroso for His Outstanding Contributions to Nucleic Acid Chemistry |
| title_full | Frontiers in Nucleic Acid Chemistry —in Memory of Professor Enrique Pedroso for His Outstanding Contributions to Nucleic Acid Chemistry |
| title_fullStr | Frontiers in Nucleic Acid Chemistry —in Memory of Professor Enrique Pedroso for His Outstanding Contributions to Nucleic Acid Chemistry |
| title_full_unstemmed | Frontiers in Nucleic Acid Chemistry —in Memory of Professor Enrique Pedroso for His Outstanding Contributions to Nucleic Acid Chemistry |
| title_short | Frontiers in Nucleic Acid Chemistry —in Memory of Professor Enrique Pedroso for His Outstanding Contributions to Nucleic Acid Chemistry |
| title_sort | frontiers in nucleic acid chemistry in memory of professor enrique pedroso for his outstanding contributions to nucleic acid chemistry |
| topic | Pu22 G-quadruplex c-myc phytochemicals circular dichroism in silico simulations molecular docking CD prediction N-acetylgalactosamine antisense oligonucleotide conjugates asialoglycoprotein receptor luciferase gene gapmers 2′,3′-dideoxynucleosides 2′,3′-didehydro-2′,3′-dideoxynucleosides synthesis zalcitabine (ddC) didanosine (ddI) stavudine (d4T) PARP1 promoter stabilizing ligand NMR fluorescence molecular modeling DNA structure RNA structure quadruplex tetrad intrinsic fluorescence DNA aptamer binding modified nucleic acids DNA polymerases nucleoside triphosphates primer extension reactions SELEX antimicrobial resistance n/a oligonucleotides DNA recognition chromosomes pyrene FISH karyotyping SNP strand invasion DNA quadruplex duplex-quadruplex equilibrium base excision repair pyridostatin glycosylase telomere 5′-functionalization small molecules conjugates of oligonucleotides solid-phase synthesis pH-sensitive phosphoramidate linkage siRNA phosphorodiamidate morpholinos (PMO) phosphoroamidate morpholinos (MO) thiophosphoramidate morpholinos (TMO) phosphoramidites amyotrophic lateral sclerosis frontotemporal dementia C9orf72 GGGGCC G4 thema EDItEUR::P Mathematics and Science::PN Chemistry::PNK Inorganic chemistry |
| topic_facet | Pu22 G-quadruplex c-myc phytochemicals circular dichroism in silico simulations molecular docking CD prediction N-acetylgalactosamine antisense oligonucleotide conjugates asialoglycoprotein receptor luciferase gene gapmers 2′,3′-dideoxynucleosides 2′,3′-didehydro-2′,3′-dideoxynucleosides synthesis zalcitabine (ddC) didanosine (ddI) stavudine (d4T) PARP1 promoter stabilizing ligand NMR fluorescence molecular modeling DNA structure RNA structure quadruplex tetrad intrinsic fluorescence DNA aptamer binding modified nucleic acids DNA polymerases nucleoside triphosphates primer extension reactions SELEX antimicrobial resistance n/a oligonucleotides DNA recognition chromosomes pyrene FISH karyotyping SNP strand invasion DNA quadruplex duplex-quadruplex equilibrium base excision repair pyridostatin glycosylase telomere 5′-functionalization small molecules conjugates of oligonucleotides solid-phase synthesis pH-sensitive phosphoramidate linkage siRNA phosphorodiamidate morpholinos (PMO) phosphoroamidate morpholinos (MO) thiophosphoramidate morpholinos (TMO) phosphoramidites amyotrophic lateral sclerosis frontotemporal dementia C9orf72 GGGGCC G4 thema EDItEUR::P Mathematics and Science::PN Chemistry::PNK Inorganic chemistry |
| url | ONIX_20240514_9783036598987_34 |