C-Reactive Protein and Cardiovascular Disease: Clinical Aspects
This Special Issue focuses on the clinical relevance of the C-reactive protein. Most physicians are familiar with it as a diagnostic biomarker. Only a few have realized that it can be a pathomolecule. After all, the biomarker is, of course, not a physiological function. The main task of CRP is to ma...
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| Định dạng: | Online |
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| Ngôn ngữ: | Tiếng Anh |
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MDPI - Multidisciplinary Digital Publishing Institute
2024
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| Những chủ đề: | |
| Truy cập trực tuyến: | ONIX_20240514_9783036599434_38 |
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| _version_ | 1869517487301722112 |
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| collection | Directory of Open Access Books |
| description | This Special Issue focuses on the clinical relevance of the C-reactive protein. Most physicians are familiar with it as a diagnostic biomarker. Only a few have realized that it can be a pathomolecule. After all, the biomarker is, of course, not a physiological function. The main task of CRP is to mark cells to be disposed of, which has been shown for decades in various animal models and has been broken down into molecular detail. The articles presented in this Special Issue reveal a broad spectrum of indications with CRP involvement. The reports unanimously support the view that CRP has a dark side. In addition to this new perspective on the pathological properties of CRP, two other new aspects are crystallizing. One is that the initial rate of CRP synthesis in an acute illness such as sepsis or myocardial infarction allows an excellent prognosis in terms of mortality or cardiac function/scar area. The other is the surprising finding that CRP impairs the desensitization of GPCRs without the need for any further damaging process. |
| format | Online |
| id | doab-20.500.12854ir-137436 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1374362024-05-14T13:04:42Z C-Reactive Protein and Cardiovascular Disease: Clinical Aspects Sheriff, Ahmed arterial stiffness C-reactive protein major adverse cardiovascular event pulse wave velocity risk stratification ST-elevation myocardial infarction left ventricular function cardiac magnetic resonance imaging acute-phase protein autoimmunity cardiovascular risk inflammation organ damage systemic lupus erythematosus adrenergic receptor desensitization GPCR signaling endothelin CRP CRP synthesis inhibition cardiovascular disease cardiovascular COVID-19 arteriosclerosis ischemic stroke therapeutic apheresis clinical activity lipid profile body composition blood component removal CRP apheresis multiple organ failure pulmonary fibrosis SARS virus troponin STEMI acute coronary syndrome mortality causes n/a thema EDItEUR::M Medicine and Nursing This Special Issue focuses on the clinical relevance of the C-reactive protein. Most physicians are familiar with it as a diagnostic biomarker. Only a few have realized that it can be a pathomolecule. After all, the biomarker is, of course, not a physiological function. The main task of CRP is to mark cells to be disposed of, which has been shown for decades in various animal models and has been broken down into molecular detail. The articles presented in this Special Issue reveal a broad spectrum of indications with CRP involvement. The reports unanimously support the view that CRP has a dark side. In addition to this new perspective on the pathological properties of CRP, two other new aspects are crystallizing. One is that the initial rate of CRP synthesis in an acute illness such as sepsis or myocardial infarction allows an excellent prognosis in terms of mortality or cardiac function/scar area. The other is the surprising finding that CRP impairs the desensitization of GPCRs without the need for any further damaging process. 2024-05-14T13:04:38Z 2024-05-14T13:04:38Z 2024 book ONIX_20240514_9783036599434_38 9783036599434 9783036599441 https://directory.doabooks.org/handle/20.500.12854/137436 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/8590 https://mdpi.com/books/pdfview/book/8590 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-9944-1 10.3390/books978-3-0365-9944-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036599434 9783036599441 132 open access |
| spellingShingle | arterial stiffness C-reactive protein major adverse cardiovascular event pulse wave velocity risk stratification ST-elevation myocardial infarction left ventricular function cardiac magnetic resonance imaging acute-phase protein autoimmunity cardiovascular risk inflammation organ damage systemic lupus erythematosus adrenergic receptor desensitization GPCR signaling endothelin CRP CRP synthesis inhibition cardiovascular disease cardiovascular COVID-19 arteriosclerosis ischemic stroke therapeutic apheresis clinical activity lipid profile body composition blood component removal CRP apheresis multiple organ failure pulmonary fibrosis SARS virus troponin STEMI acute coronary syndrome mortality causes n/a thema EDItEUR::M Medicine and Nursing C-Reactive Protein and Cardiovascular Disease: Clinical Aspects |
| title | C-Reactive Protein and Cardiovascular Disease: Clinical Aspects |
| title_full | C-Reactive Protein and Cardiovascular Disease: Clinical Aspects |
| title_fullStr | C-Reactive Protein and Cardiovascular Disease: Clinical Aspects |
| title_full_unstemmed | C-Reactive Protein and Cardiovascular Disease: Clinical Aspects |
| title_short | C-Reactive Protein and Cardiovascular Disease: Clinical Aspects |
| title_sort | c reactive protein and cardiovascular disease clinical aspects |
| topic | arterial stiffness C-reactive protein major adverse cardiovascular event pulse wave velocity risk stratification ST-elevation myocardial infarction left ventricular function cardiac magnetic resonance imaging acute-phase protein autoimmunity cardiovascular risk inflammation organ damage systemic lupus erythematosus adrenergic receptor desensitization GPCR signaling endothelin CRP CRP synthesis inhibition cardiovascular disease cardiovascular COVID-19 arteriosclerosis ischemic stroke therapeutic apheresis clinical activity lipid profile body composition blood component removal CRP apheresis multiple organ failure pulmonary fibrosis SARS virus troponin STEMI acute coronary syndrome mortality causes n/a thema EDItEUR::M Medicine and Nursing |
| topic_facet | arterial stiffness C-reactive protein major adverse cardiovascular event pulse wave velocity risk stratification ST-elevation myocardial infarction left ventricular function cardiac magnetic resonance imaging acute-phase protein autoimmunity cardiovascular risk inflammation organ damage systemic lupus erythematosus adrenergic receptor desensitization GPCR signaling endothelin CRP CRP synthesis inhibition cardiovascular disease cardiovascular COVID-19 arteriosclerosis ischemic stroke therapeutic apheresis clinical activity lipid profile body composition blood component removal CRP apheresis multiple organ failure pulmonary fibrosis SARS virus troponin STEMI acute coronary syndrome mortality causes n/a thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20240514_9783036599434_38 |