Biomarkers of Tumor Metastasis and Invasiveness
The molecular characterization of tumors, investigated particularly through proteogenomic analyses, has led to a revolution in cancer research. Over the last decade, the development of quantitative proteomics, together with other major technological breakthroughs, have identified candidate biomarker...
সংরক্ষণ করুন:
| বিন্যাস: | Online |
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| ভাষা: | ইংরেজি |
| প্রকাশিত: |
MDPI - Multidisciplinary Digital Publishing Institute
2024
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | ONIX_20240514_9783039285907_70 |
| ট্যাগগুলো: |
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| _version_ | 1869522555309654016 |
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| collection | Directory of Open Access Books |
| description | The molecular characterization of tumors, investigated particularly through proteogenomic analyses, has led to a revolution in cancer research. Over the last decade, the development of quantitative proteomics, together with other major technological breakthroughs, have identified candidate biomarkers for diagnosis, prognosis, and drug efficacy/resistance follow-up. These improvements have allowed researchers to explore the capability of cancer cells to invade, metastasize, and finally, destroy normal tissues and organs. In parallel, new hypotheses have been formulated, and the means cancer cells use to exploit their surrounding environment have begun to be deciphered, leading to new therapeutic approaches. This Special Issue covers all these aspects, revealing new, recent insights on the molecular networks controlling the tumor invasiveness process; dynamic interactions between cancer cells; and the host stroma, stemness and epithelial-to-mesenchymal transition, as well as the links between inflammation and tumor metastasis. The scope is extended to studies on all cancer histological types (original research articles and reviews) conducted on experimental tumor models, tumor samples, and/or biofluids from patients with cancer. |
| format | Online |
| id | doab-20.500.12854ir-137468 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1374682024-05-14T13:10:38Z Biomarkers of Tumor Metastasis and Invasiveness L. Pouliquen, Daniel Núñez González, Cristina SOX9 pancreatic cancer plasticity metastasis EMT chemoresistance mitochondrial DNA tumor progression immune escape ADAM biomarker gastrointestinal tumours non-small cell lung cancer adjuvant chemotherapy actinin-4 metastatic ability serum tumor markers tumor metastasis tumor stage prediction MAPK15 EP3 p50 LUAD CCR7 CCL19 extrahepatic cholangiocarcinoma epithelial–mesenchymal transition tumor budding defense response osteosarcoma prognosis immune therapy Glioblastoma sortilin cancer biomarkers cancer therapeutic targets gastric cancer surgery peripheral lymphocyte subsets prognostic nutritional index prognostic factor endometrial cancer advanced stage outcome high-grade CA125 oral cancer NLRP3 lymph node spleen lung malignant mesothelioma metabolism mitochondria long-chain specific acyl-CoA dehydrogenase fatty acid β-oxidation VIP ZEB1 cancer gastrointestinal cancers multiple myeloma extramedullary multiple myeloma extramedullary disease proteomics mass spectrometry clinical proteomics metabolomics exosomes prostasin matriptase protease activation cascade gelatinase activity lymphoma IMP3 lip cancer squamous cell carcinoma ear cancer skin cancer HNSCC n/a thema EDItEUR::M Medicine and Nursing The molecular characterization of tumors, investigated particularly through proteogenomic analyses, has led to a revolution in cancer research. Over the last decade, the development of quantitative proteomics, together with other major technological breakthroughs, have identified candidate biomarkers for diagnosis, prognosis, and drug efficacy/resistance follow-up. These improvements have allowed researchers to explore the capability of cancer cells to invade, metastasize, and finally, destroy normal tissues and organs. In parallel, new hypotheses have been formulated, and the means cancer cells use to exploit their surrounding environment have begun to be deciphered, leading to new therapeutic approaches. This Special Issue covers all these aspects, revealing new, recent insights on the molecular networks controlling the tumor invasiveness process; dynamic interactions between cancer cells; and the host stroma, stemness and epithelial-to-mesenchymal transition, as well as the links between inflammation and tumor metastasis. The scope is extended to studies on all cancer histological types (original research articles and reviews) conducted on experimental tumor models, tumor samples, and/or biofluids from patients with cancer. 2024-05-14T13:10:32Z 2024-05-14T13:10:32Z 2024 book ONIX_20240514_9783039285907_70 9783039285907 9783036599991 https://directory.doabooks.org/handle/20.500.12854/137468 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/8623 https://mdpi.com/books/pdfview/book/8623 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-9999-1 10.3390/books978-3-0365-9999-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039285907 9783036599991 306 open access |
| spellingShingle | SOX9 pancreatic cancer plasticity metastasis EMT chemoresistance mitochondrial DNA tumor progression immune escape ADAM biomarker gastrointestinal tumours non-small cell lung cancer adjuvant chemotherapy actinin-4 metastatic ability serum tumor markers tumor metastasis tumor stage prediction MAPK15 EP3 p50 LUAD CCR7 CCL19 extrahepatic cholangiocarcinoma epithelial–mesenchymal transition tumor budding defense response osteosarcoma prognosis immune therapy Glioblastoma sortilin cancer biomarkers cancer therapeutic targets gastric cancer surgery peripheral lymphocyte subsets prognostic nutritional index prognostic factor endometrial cancer advanced stage outcome high-grade CA125 oral cancer NLRP3 lymph node spleen lung malignant mesothelioma metabolism mitochondria long-chain specific acyl-CoA dehydrogenase fatty acid β-oxidation VIP ZEB1 cancer gastrointestinal cancers multiple myeloma extramedullary multiple myeloma extramedullary disease proteomics mass spectrometry clinical proteomics metabolomics exosomes prostasin matriptase protease activation cascade gelatinase activity lymphoma IMP3 lip cancer squamous cell carcinoma ear cancer skin cancer HNSCC n/a thema EDItEUR::M Medicine and Nursing Biomarkers of Tumor Metastasis and Invasiveness |
| title | Biomarkers of Tumor Metastasis and Invasiveness |
| title_full | Biomarkers of Tumor Metastasis and Invasiveness |
| title_fullStr | Biomarkers of Tumor Metastasis and Invasiveness |
| title_full_unstemmed | Biomarkers of Tumor Metastasis and Invasiveness |
| title_short | Biomarkers of Tumor Metastasis and Invasiveness |
| title_sort | biomarkers of tumor metastasis and invasiveness |
| topic | SOX9 pancreatic cancer plasticity metastasis EMT chemoresistance mitochondrial DNA tumor progression immune escape ADAM biomarker gastrointestinal tumours non-small cell lung cancer adjuvant chemotherapy actinin-4 metastatic ability serum tumor markers tumor metastasis tumor stage prediction MAPK15 EP3 p50 LUAD CCR7 CCL19 extrahepatic cholangiocarcinoma epithelial–mesenchymal transition tumor budding defense response osteosarcoma prognosis immune therapy Glioblastoma sortilin cancer biomarkers cancer therapeutic targets gastric cancer surgery peripheral lymphocyte subsets prognostic nutritional index prognostic factor endometrial cancer advanced stage outcome high-grade CA125 oral cancer NLRP3 lymph node spleen lung malignant mesothelioma metabolism mitochondria long-chain specific acyl-CoA dehydrogenase fatty acid β-oxidation VIP ZEB1 cancer gastrointestinal cancers multiple myeloma extramedullary multiple myeloma extramedullary disease proteomics mass spectrometry clinical proteomics metabolomics exosomes prostasin matriptase protease activation cascade gelatinase activity lymphoma IMP3 lip cancer squamous cell carcinoma ear cancer skin cancer HNSCC n/a thema EDItEUR::M Medicine and Nursing |
| topic_facet | SOX9 pancreatic cancer plasticity metastasis EMT chemoresistance mitochondrial DNA tumor progression immune escape ADAM biomarker gastrointestinal tumours non-small cell lung cancer adjuvant chemotherapy actinin-4 metastatic ability serum tumor markers tumor metastasis tumor stage prediction MAPK15 EP3 p50 LUAD CCR7 CCL19 extrahepatic cholangiocarcinoma epithelial–mesenchymal transition tumor budding defense response osteosarcoma prognosis immune therapy Glioblastoma sortilin cancer biomarkers cancer therapeutic targets gastric cancer surgery peripheral lymphocyte subsets prognostic nutritional index prognostic factor endometrial cancer advanced stage outcome high-grade CA125 oral cancer NLRP3 lymph node spleen lung malignant mesothelioma metabolism mitochondria long-chain specific acyl-CoA dehydrogenase fatty acid β-oxidation VIP ZEB1 cancer gastrointestinal cancers multiple myeloma extramedullary multiple myeloma extramedullary disease proteomics mass spectrometry clinical proteomics metabolomics exosomes prostasin matriptase protease activation cascade gelatinase activity lymphoma IMP3 lip cancer squamous cell carcinoma ear cancer skin cancer HNSCC n/a thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20240514_9783039285907_70 |