Preparation of Radiopharmaceuticals and Their Use in Drug Development
The purpose of this Special Issue is to bring together research and review papers that use radiopharmaceuticals in drug development. Labeling a potential drug with a radionuclide for imaging and injecting radiopharmaceuticals into animals or humans can immediately provide information about the in vi...
Sparad:
| Materialtyp: | Online |
|---|---|
| Språk: | engelska |
| Utgiven: |
MDPI - Multidisciplinary Digital Publishing Institute
2024
|
| Ämnen: | |
| Länkar: | ONIX_20240514_9783039286270_80 |
| Taggar: |
Inga taggar, Lägg till första taggen!
|
| _version_ | 1869519172222844928 |
|---|---|
| collection | Directory of Open Access Books |
| description | The purpose of this Special Issue is to bring together research and review papers that use radiopharmaceuticals in drug development. Labeling a potential drug with a radionuclide for imaging and injecting radiopharmaceuticals into animals or humans can immediately provide information about the in vivo destiny of the compound through the application of PET or SPECT scanners. Radionuclides can be useful throughout the whole process of developing new drugs; in particular, if the results obtained are negative and the potential drug can be discarded early on in the process, considerable effort and money can be saved. An alternative way to obtain information about the in vivo destiny/effect of a potential drug is to imagine, for example, a target organ or a tumor with radiopharmaceuticals before and after treatment with a drug. Determining how a drug is metabolized is an integrated part of drug development. Labeling a drug with a radionuclide and providing it with a radioactive tag can help in subsequently determining its location and quantifying metabolites. If the metabolites can be extracted, the solutions can be examined through analytical measurements. Using ionizing radiation in the treatment of tumors is also an application for radiopharmaceuticals which is expected to expand greatly in the years to come. By labeling a specific compound with a radionuclide used for diagnostics we can establish whether it accumulates in the tumor. The same compound is thereafter combined with a radionuclide for treatment. This Special Issue contains seven original research papers, one communication, and two reviews. |
| format | Online |
| id | doab-20.500.12854ir-137478 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1374782024-05-14T13:13:45Z Preparation of Radiopharmaceuticals and Their Use in Drug Development Borup Jensen, Svend NET ADHD cocaine dependence BAT PET FAPPI Cys-Annexin V site-specific labeling 18F-FBEM apoptosis imaging carbon-11 radiosynthesis isradipine positron emission tomography neuroimaging calcium channel blocker PDE2A Alzheimer’s disease PET imaging in brain micellar HPLC gold nanoparticles dual radiolabeling biodistribution profiles Sprague Dawley rats 68Ga chemistry receptor targeting peptide GMP dosimetry metal complexes macrocyclic ligands radiopharmaceuticals tacn derivative phosphinate complexes gallium complexes radiolabelling PET tracer development molecular imaging PSMA prostate cancer PET/CT 68Ga-HBED-CC-(Ahx)Lys-NH-CO-NH-Glu 68Ga-DKFZ-PSMA-11 68Ga-PSMAHBED fluorine-18 metabolism stability deuterium α7 nAChR pharmacophore thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues The purpose of this Special Issue is to bring together research and review papers that use radiopharmaceuticals in drug development. Labeling a potential drug with a radionuclide for imaging and injecting radiopharmaceuticals into animals or humans can immediately provide information about the in vivo destiny of the compound through the application of PET or SPECT scanners. Radionuclides can be useful throughout the whole process of developing new drugs; in particular, if the results obtained are negative and the potential drug can be discarded early on in the process, considerable effort and money can be saved. An alternative way to obtain information about the in vivo destiny/effect of a potential drug is to imagine, for example, a target organ or a tumor with radiopharmaceuticals before and after treatment with a drug. Determining how a drug is metabolized is an integrated part of drug development. Labeling a drug with a radionuclide and providing it with a radioactive tag can help in subsequently determining its location and quantifying metabolites. If the metabolites can be extracted, the solutions can be examined through analytical measurements. Using ionizing radiation in the treatment of tumors is also an application for radiopharmaceuticals which is expected to expand greatly in the years to come. By labeling a specific compound with a radionuclide used for diagnostics we can establish whether it accumulates in the tumor. The same compound is thereafter combined with a radionuclide for treatment. This Special Issue contains seven original research papers, one communication, and two reviews. 2024-05-14T13:13:25Z 2024-05-14T13:13:25Z 2024 book ONIX_20240514_9783039286270_80 9783039286270 9783725800001 https://directory.doabooks.org/handle/20.500.12854/137478 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/8635 https://mdpi.com/books/pdfview/book/8635 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-0000-1 10.3390/books978-3-7258-0000-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039286270 9783725800001 232 open access |
| spellingShingle | NET ADHD cocaine dependence BAT PET FAPPI Cys-Annexin V site-specific labeling 18F-FBEM apoptosis imaging carbon-11 radiosynthesis isradipine positron emission tomography neuroimaging calcium channel blocker PDE2A Alzheimer’s disease PET imaging in brain micellar HPLC gold nanoparticles dual radiolabeling biodistribution profiles Sprague Dawley rats 68Ga chemistry receptor targeting peptide GMP dosimetry metal complexes macrocyclic ligands radiopharmaceuticals tacn derivative phosphinate complexes gallium complexes radiolabelling PET tracer development molecular imaging PSMA prostate cancer PET/CT 68Ga-HBED-CC-(Ahx)Lys-NH-CO-NH-Glu 68Ga-DKFZ-PSMA-11 68Ga-PSMAHBED fluorine-18 metabolism stability deuterium α7 nAChR pharmacophore thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues Preparation of Radiopharmaceuticals and Their Use in Drug Development |
| title | Preparation of Radiopharmaceuticals and Their Use in Drug Development |
| title_full | Preparation of Radiopharmaceuticals and Their Use in Drug Development |
| title_fullStr | Preparation of Radiopharmaceuticals and Their Use in Drug Development |
| title_full_unstemmed | Preparation of Radiopharmaceuticals and Their Use in Drug Development |
| title_short | Preparation of Radiopharmaceuticals and Their Use in Drug Development |
| title_sort | preparation of radiopharmaceuticals and their use in drug development |
| topic | NET ADHD cocaine dependence BAT PET FAPPI Cys-Annexin V site-specific labeling 18F-FBEM apoptosis imaging carbon-11 radiosynthesis isradipine positron emission tomography neuroimaging calcium channel blocker PDE2A Alzheimer’s disease PET imaging in brain micellar HPLC gold nanoparticles dual radiolabeling biodistribution profiles Sprague Dawley rats 68Ga chemistry receptor targeting peptide GMP dosimetry metal complexes macrocyclic ligands radiopharmaceuticals tacn derivative phosphinate complexes gallium complexes radiolabelling PET tracer development molecular imaging PSMA prostate cancer PET/CT 68Ga-HBED-CC-(Ahx)Lys-NH-CO-NH-Glu 68Ga-DKFZ-PSMA-11 68Ga-PSMAHBED fluorine-18 metabolism stability deuterium α7 nAChR pharmacophore thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues |
| topic_facet | NET ADHD cocaine dependence BAT PET FAPPI Cys-Annexin V site-specific labeling 18F-FBEM apoptosis imaging carbon-11 radiosynthesis isradipine positron emission tomography neuroimaging calcium channel blocker PDE2A Alzheimer’s disease PET imaging in brain micellar HPLC gold nanoparticles dual radiolabeling biodistribution profiles Sprague Dawley rats 68Ga chemistry receptor targeting peptide GMP dosimetry metal complexes macrocyclic ligands radiopharmaceuticals tacn derivative phosphinate complexes gallium complexes radiolabelling PET tracer development molecular imaging PSMA prostate cancer PET/CT 68Ga-HBED-CC-(Ahx)Lys-NH-CO-NH-Glu 68Ga-DKFZ-PSMA-11 68Ga-PSMAHBED fluorine-18 metabolism stability deuterium α7 nAChR pharmacophore thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues |
| url | ONIX_20240514_9783039286270_80 |