The Role of Natural Products on Diabetes Mellitus Treatment
The utilization of medicinal plants in the treatment of diabetes mellitus (DM) holds significant promise due to their diverse bioactive compounds. These plants have been historically acknowledged for their potential in managing DM and its complications. They often contain secondary metabolites with...
সংরক্ষণ করুন:
| বিন্যাস: | Online |
|---|---|
| ভাষা: | ইংরেজি |
| প্রকাশিত: |
MDPI - Multidisciplinary Digital Publishing Institute
2024
|
| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | ONIX_20240514_9783725800100_122 |
| ট্যাগগুলো: |
কোনো ট্যাগ নেই, প্রথমজন হিসাবে ট্যাগ করুন!
|
| _version_ | 1869529093491392512 |
|---|---|
| collection | Directory of Open Access Books |
| description | The utilization of medicinal plants in the treatment of diabetes mellitus (DM) holds significant promise due to their diverse bioactive compounds. These plants have been historically acknowledged for their potential in managing DM and its complications. They often contain secondary metabolites with inherent hypoglycemic properties, aiding in regulating blood glucose levels. Several plants and secondary metabolites have shown effectiveness in improving insulin sensitivity, enhancing glucose uptake, and mitigating the adverse effects associated with DM. For instance, bitter melon (Momordica charantia) contains charantin and polypeptide-p, both known for their hypoglycemic effects. Additionally, fenugreek (Trigonella foenum-graecum) exhibits hypoglycemic properties attributed to the presence of trigonelline and diosgenin.The complex array of bioactive compounds present in medicinal plants offers a multifaceted approach to managing DM. Flavonoids, alkaloids, polyphenols, and terpenoids found in these plants exert antioxidant, anti-inflammatory, and anti-glycation effects, mitigating oxidative stress and inflammation often associated with diabetic complications.This Special Issue highlights the role of natural products in the treatment of DM, including recent patents as well as the effects of characterized extracts and the cellular mechanisms of isolated secondary metabolites in preclinical and clinical studies. |
| format | Online |
| id | doab-20.500.12854ir-137520 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1375202024-05-14T13:23:03Z The Role of Natural Products on Diabetes Mellitus Treatment Aragon Novoa, Diana Marcela Silva, Fátima Regina Mena Barreto narirutin naringenin rutinoside isonaringin molecular docking mechanism of action enzyme receptors diabetes mellitus neurotoxicity curcumin nanoparticle zinc oxide nanoparticle metformin inflammation oxidative stress apoptosis acarbose combination approach Ecklonia radiata fucoidan type 2 diabetes management Lavandula pedunculata (Mill.) Cav. Punica granatum L. Trigonella foenum-graecum L. diabetes glucose intestinal absorption oral glucose tolerance test pregnancy type 1 diabetes mellitus beta-cell insulin C-peptide hypoglycemia n-3 PUFA placenta fetus oleuropein Mediterranean diet metabolic syndrome silymarin combination therapy liver steatosis pre-diabetes advanced glycation end products polydatin salivary gland type 2 biological products plants antioxidants therapeutics natural products phenols ageing diabetic cardiomyopathy mitochondrial longevity electron transport chain BGP-15 nicotinic acid NAD precursor bioactive molecule NA/STZ-induced diabetes mellitus Balanitis aegyptiaca fruit seed aqueous extracts edible mushroom insulin resistance polysaccharide vitamin D α-glucosidase α-amylase Artemisia absinthium antioxidant activity phenolic compounds hyperglycemia pancreatic α-amylase intestinal α-glucosidase rosinidin streptozotocin lipid profile proinflammatory cytokine CXCL16 ADAM10 NF-κβ pancreatic islets resveratrol T1D sweeteners D-Pinitol carob fruit pituitary hormones type 2 diabetes Chinese herbal medicine YH1 gut microbiota bile acids elderberry yarrow cornelian cherry bilberry wild strawberry rosehip raspberry blackberry stinging nettle Trigonella foenum-graecum fenugreek prediabetes fasting blood glucose post-prandial glucose flavonoid rutin antioxidant lipidosis flavonoids polyphenols patent marine natural products Dysidea avara sesquiterpene-type quinones avarone aldose reductase protein tyrosine phosphatase 1B dual target inhibitors Orthosiphon stamineus GLUT4 anti-oxidant phytochemicals thema EDItEUR::M Medicine and Nursing The utilization of medicinal plants in the treatment of diabetes mellitus (DM) holds significant promise due to their diverse bioactive compounds. These plants have been historically acknowledged for their potential in managing DM and its complications. They often contain secondary metabolites with inherent hypoglycemic properties, aiding in regulating blood glucose levels. Several plants and secondary metabolites have shown effectiveness in improving insulin sensitivity, enhancing glucose uptake, and mitigating the adverse effects associated with DM. For instance, bitter melon (Momordica charantia) contains charantin and polypeptide-p, both known for their hypoglycemic effects. Additionally, fenugreek (Trigonella foenum-graecum) exhibits hypoglycemic properties attributed to the presence of trigonelline and diosgenin.The complex array of bioactive compounds present in medicinal plants offers a multifaceted approach to managing DM. Flavonoids, alkaloids, polyphenols, and terpenoids found in these plants exert antioxidant, anti-inflammatory, and anti-glycation effects, mitigating oxidative stress and inflammation often associated with diabetic complications.This Special Issue highlights the role of natural products in the treatment of DM, including recent patents as well as the effects of characterized extracts and the cellular mechanisms of isolated secondary metabolites in preclinical and clinical studies. 2024-05-14T13:22:56Z 2024-05-14T13:22:56Z 2024 book ONIX_20240514_9783725800100_122 9783725800100 9783725800094 https://directory.doabooks.org/handle/20.500.12854/137520 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/8680 https://mdpi.com/books/pdfview/book/8680 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-0009-4 10.3390/books978-3-7258-0009-4 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725800100 9783725800094 436 open access |
| spellingShingle | narirutin naringenin rutinoside isonaringin molecular docking mechanism of action enzyme receptors diabetes mellitus neurotoxicity curcumin nanoparticle zinc oxide nanoparticle metformin inflammation oxidative stress apoptosis acarbose combination approach Ecklonia radiata fucoidan type 2 diabetes management Lavandula pedunculata (Mill.) Cav. Punica granatum L. Trigonella foenum-graecum L. diabetes glucose intestinal absorption oral glucose tolerance test pregnancy type 1 diabetes mellitus beta-cell insulin C-peptide hypoglycemia n-3 PUFA placenta fetus oleuropein Mediterranean diet metabolic syndrome silymarin combination therapy liver steatosis pre-diabetes advanced glycation end products polydatin salivary gland type 2 biological products plants antioxidants therapeutics natural products phenols ageing diabetic cardiomyopathy mitochondrial longevity electron transport chain BGP-15 nicotinic acid NAD precursor bioactive molecule NA/STZ-induced diabetes mellitus Balanitis aegyptiaca fruit seed aqueous extracts edible mushroom insulin resistance polysaccharide vitamin D α-glucosidase α-amylase Artemisia absinthium antioxidant activity phenolic compounds hyperglycemia pancreatic α-amylase intestinal α-glucosidase rosinidin streptozotocin lipid profile proinflammatory cytokine CXCL16 ADAM10 NF-κβ pancreatic islets resveratrol T1D sweeteners D-Pinitol carob fruit pituitary hormones type 2 diabetes Chinese herbal medicine YH1 gut microbiota bile acids elderberry yarrow cornelian cherry bilberry wild strawberry rosehip raspberry blackberry stinging nettle Trigonella foenum-graecum fenugreek prediabetes fasting blood glucose post-prandial glucose flavonoid rutin antioxidant lipidosis flavonoids polyphenols patent marine natural products Dysidea avara sesquiterpene-type quinones avarone aldose reductase protein tyrosine phosphatase 1B dual target inhibitors Orthosiphon stamineus GLUT4 anti-oxidant phytochemicals thema EDItEUR::M Medicine and Nursing The Role of Natural Products on Diabetes Mellitus Treatment |
| title | The Role of Natural Products on Diabetes Mellitus Treatment |
| title_full | The Role of Natural Products on Diabetes Mellitus Treatment |
| title_fullStr | The Role of Natural Products on Diabetes Mellitus Treatment |
| title_full_unstemmed | The Role of Natural Products on Diabetes Mellitus Treatment |
| title_short | The Role of Natural Products on Diabetes Mellitus Treatment |
| title_sort | role of natural products on diabetes mellitus treatment |
| topic | narirutin naringenin rutinoside isonaringin molecular docking mechanism of action enzyme receptors diabetes mellitus neurotoxicity curcumin nanoparticle zinc oxide nanoparticle metformin inflammation oxidative stress apoptosis acarbose combination approach Ecklonia radiata fucoidan type 2 diabetes management Lavandula pedunculata (Mill.) Cav. Punica granatum L. Trigonella foenum-graecum L. diabetes glucose intestinal absorption oral glucose tolerance test pregnancy type 1 diabetes mellitus beta-cell insulin C-peptide hypoglycemia n-3 PUFA placenta fetus oleuropein Mediterranean diet metabolic syndrome silymarin combination therapy liver steatosis pre-diabetes advanced glycation end products polydatin salivary gland type 2 biological products plants antioxidants therapeutics natural products phenols ageing diabetic cardiomyopathy mitochondrial longevity electron transport chain BGP-15 nicotinic acid NAD precursor bioactive molecule NA/STZ-induced diabetes mellitus Balanitis aegyptiaca fruit seed aqueous extracts edible mushroom insulin resistance polysaccharide vitamin D α-glucosidase α-amylase Artemisia absinthium antioxidant activity phenolic compounds hyperglycemia pancreatic α-amylase intestinal α-glucosidase rosinidin streptozotocin lipid profile proinflammatory cytokine CXCL16 ADAM10 NF-κβ pancreatic islets resveratrol T1D sweeteners D-Pinitol carob fruit pituitary hormones type 2 diabetes Chinese herbal medicine YH1 gut microbiota bile acids elderberry yarrow cornelian cherry bilberry wild strawberry rosehip raspberry blackberry stinging nettle Trigonella foenum-graecum fenugreek prediabetes fasting blood glucose post-prandial glucose flavonoid rutin antioxidant lipidosis flavonoids polyphenols patent marine natural products Dysidea avara sesquiterpene-type quinones avarone aldose reductase protein tyrosine phosphatase 1B dual target inhibitors Orthosiphon stamineus GLUT4 anti-oxidant phytochemicals thema EDItEUR::M Medicine and Nursing |
| topic_facet | narirutin naringenin rutinoside isonaringin molecular docking mechanism of action enzyme receptors diabetes mellitus neurotoxicity curcumin nanoparticle zinc oxide nanoparticle metformin inflammation oxidative stress apoptosis acarbose combination approach Ecklonia radiata fucoidan type 2 diabetes management Lavandula pedunculata (Mill.) Cav. Punica granatum L. Trigonella foenum-graecum L. diabetes glucose intestinal absorption oral glucose tolerance test pregnancy type 1 diabetes mellitus beta-cell insulin C-peptide hypoglycemia n-3 PUFA placenta fetus oleuropein Mediterranean diet metabolic syndrome silymarin combination therapy liver steatosis pre-diabetes advanced glycation end products polydatin salivary gland type 2 biological products plants antioxidants therapeutics natural products phenols ageing diabetic cardiomyopathy mitochondrial longevity electron transport chain BGP-15 nicotinic acid NAD precursor bioactive molecule NA/STZ-induced diabetes mellitus Balanitis aegyptiaca fruit seed aqueous extracts edible mushroom insulin resistance polysaccharide vitamin D α-glucosidase α-amylase Artemisia absinthium antioxidant activity phenolic compounds hyperglycemia pancreatic α-amylase intestinal α-glucosidase rosinidin streptozotocin lipid profile proinflammatory cytokine CXCL16 ADAM10 NF-κβ pancreatic islets resveratrol T1D sweeteners D-Pinitol carob fruit pituitary hormones type 2 diabetes Chinese herbal medicine YH1 gut microbiota bile acids elderberry yarrow cornelian cherry bilberry wild strawberry rosehip raspberry blackberry stinging nettle Trigonella foenum-graecum fenugreek prediabetes fasting blood glucose post-prandial glucose flavonoid rutin antioxidant lipidosis flavonoids polyphenols patent marine natural products Dysidea avara sesquiterpene-type quinones avarone aldose reductase protein tyrosine phosphatase 1B dual target inhibitors Orthosiphon stamineus GLUT4 anti-oxidant phytochemicals thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20240514_9783725800100_122 |