Versatility of Glutathione Transferase Proteins
Glutathione transferases are abundant enzymes in various aerobic organisms in which they provide cellular protection against reactive compounds that cause mutations and cancer. Their evolution may have been a response to oxidative stress caused by oxygen in the atmosphere. These enzymes also partici...
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| Format: | Online |
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| Langue: | anglais |
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MDPI - Multidisciplinary Digital Publishing Institute
2024
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| Accès en ligne: | ONIX_20240514_9783725804535_303 |
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| description | Glutathione transferases are abundant enzymes in various aerobic organisms in which they provide cellular protection against reactive compounds that cause mutations and cancer. Their evolution may have been a response to oxidative stress caused by oxygen in the atmosphere. These enzymes also participate in steroid hormone synthesis in both mammals and insects and play important roles in the biotransformation of signaling substances. Their multiple roles also include the binding and transportation of molecules in cells. |
| format | Online |
| id | doab-20.500.12854ir-137706 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1377062024-05-14T14:11:43Z Versatility of Glutathione Transferase Proteins Mannervik, Bengt glutathione-S-transferase nitroglycerin nitric oxide vasodilation glutathione transferase glutathione cyanobacteria Synechocystis sp. PCC 6803 crystallography biochemistry phylogeny insects olfaction taste chemosensory organs detoxification evolution flavor enzyme detoxication substrate promiscuity hydroxynonenal lipid peroxidation lipid alkenals enzyme mechanism deuterium exchange glutathione S-transferases (GSTs) insecticide insect growth regulator (IGR) mosquito ecdysone ecdysteroid Drosophila melanogaster Aedes aegypti steroid flavonoid anticancer drugs cancer human glutathione transferase P1-1 (hGSTP1-1) enzyme inhibition multidrug resistance pesticide Glutathione S-transferases (GSTs) antioxidants cancer-cell signaling cell survival chemoresistance xenobiotic compounds metabolism GST inhibitors glutathionylation oxidative stress JNK apoptosis GST Polymorphism SARS-CoV-2 COVID-19 Nobo Anopheles gambiae GSTE8 malaria ketosteroids ecdysteroidogenesis intracellular chloride channel metaxin failed axon connections homolog ganglioside-induced differentiation-associated protein glutathione S-transferase C-terminal domain-containing protein multi-tRNA synthetase complex eukaryotic elongation factor 1 structure prediction estrogen glutathione transferase A3-3 (GST A3-3) steroidogenesis testes testosterone progesterone n/a thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues Glutathione transferases are abundant enzymes in various aerobic organisms in which they provide cellular protection against reactive compounds that cause mutations and cancer. Their evolution may have been a response to oxidative stress caused by oxygen in the atmosphere. These enzymes also participate in steroid hormone synthesis in both mammals and insects and play important roles in the biotransformation of signaling substances. Their multiple roles also include the binding and transportation of molecules in cells. 2024-05-14T14:11:34Z 2024-05-14T14:11:34Z 2024 book ONIX_20240514_9783725804535_303 9783725804535 9783725804542 https://directory.doabooks.org/handle/20.500.12854/137706 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/8931 https://mdpi.com/books/pdfview/book/8931 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-0454-2 10.3390/books978-3-7258-0454-2 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725804535 9783725804542 164 open access |
| spellingShingle | glutathione-S-transferase nitroglycerin nitric oxide vasodilation glutathione transferase glutathione cyanobacteria Synechocystis sp. PCC 6803 crystallography biochemistry phylogeny insects olfaction taste chemosensory organs detoxification evolution flavor enzyme detoxication substrate promiscuity hydroxynonenal lipid peroxidation lipid alkenals enzyme mechanism deuterium exchange glutathione S-transferases (GSTs) insecticide insect growth regulator (IGR) mosquito ecdysone ecdysteroid Drosophila melanogaster Aedes aegypti steroid flavonoid anticancer drugs cancer human glutathione transferase P1-1 (hGSTP1-1) enzyme inhibition multidrug resistance pesticide Glutathione S-transferases (GSTs) antioxidants cancer-cell signaling cell survival chemoresistance xenobiotic compounds metabolism GST inhibitors glutathionylation oxidative stress JNK apoptosis GST Polymorphism SARS-CoV-2 COVID-19 Nobo Anopheles gambiae GSTE8 malaria ketosteroids ecdysteroidogenesis intracellular chloride channel metaxin failed axon connections homolog ganglioside-induced differentiation-associated protein glutathione S-transferase C-terminal domain-containing protein multi-tRNA synthetase complex eukaryotic elongation factor 1 structure prediction estrogen glutathione transferase A3-3 (GST A3-3) steroidogenesis testes testosterone progesterone n/a thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues Versatility of Glutathione Transferase Proteins |
| title | Versatility of Glutathione Transferase Proteins |
| title_full | Versatility of Glutathione Transferase Proteins |
| title_fullStr | Versatility of Glutathione Transferase Proteins |
| title_full_unstemmed | Versatility of Glutathione Transferase Proteins |
| title_short | Versatility of Glutathione Transferase Proteins |
| title_sort | versatility of glutathione transferase proteins |
| topic | glutathione-S-transferase nitroglycerin nitric oxide vasodilation glutathione transferase glutathione cyanobacteria Synechocystis sp. PCC 6803 crystallography biochemistry phylogeny insects olfaction taste chemosensory organs detoxification evolution flavor enzyme detoxication substrate promiscuity hydroxynonenal lipid peroxidation lipid alkenals enzyme mechanism deuterium exchange glutathione S-transferases (GSTs) insecticide insect growth regulator (IGR) mosquito ecdysone ecdysteroid Drosophila melanogaster Aedes aegypti steroid flavonoid anticancer drugs cancer human glutathione transferase P1-1 (hGSTP1-1) enzyme inhibition multidrug resistance pesticide Glutathione S-transferases (GSTs) antioxidants cancer-cell signaling cell survival chemoresistance xenobiotic compounds metabolism GST inhibitors glutathionylation oxidative stress JNK apoptosis GST Polymorphism SARS-CoV-2 COVID-19 Nobo Anopheles gambiae GSTE8 malaria ketosteroids ecdysteroidogenesis intracellular chloride channel metaxin failed axon connections homolog ganglioside-induced differentiation-associated protein glutathione S-transferase C-terminal domain-containing protein multi-tRNA synthetase complex eukaryotic elongation factor 1 structure prediction estrogen glutathione transferase A3-3 (GST A3-3) steroidogenesis testes testosterone progesterone n/a thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues |
| topic_facet | glutathione-S-transferase nitroglycerin nitric oxide vasodilation glutathione transferase glutathione cyanobacteria Synechocystis sp. PCC 6803 crystallography biochemistry phylogeny insects olfaction taste chemosensory organs detoxification evolution flavor enzyme detoxication substrate promiscuity hydroxynonenal lipid peroxidation lipid alkenals enzyme mechanism deuterium exchange glutathione S-transferases (GSTs) insecticide insect growth regulator (IGR) mosquito ecdysone ecdysteroid Drosophila melanogaster Aedes aegypti steroid flavonoid anticancer drugs cancer human glutathione transferase P1-1 (hGSTP1-1) enzyme inhibition multidrug resistance pesticide Glutathione S-transferases (GSTs) antioxidants cancer-cell signaling cell survival chemoresistance xenobiotic compounds metabolism GST inhibitors glutathionylation oxidative stress JNK apoptosis GST Polymorphism SARS-CoV-2 COVID-19 Nobo Anopheles gambiae GSTE8 malaria ketosteroids ecdysteroidogenesis intracellular chloride channel metaxin failed axon connections homolog ganglioside-induced differentiation-associated protein glutathione S-transferase C-terminal domain-containing protein multi-tRNA synthetase complex eukaryotic elongation factor 1 structure prediction estrogen glutathione transferase A3-3 (GST A3-3) steroidogenesis testes testosterone progesterone n/a thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues |
| url | ONIX_20240514_9783725804535_303 |