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Advances in the Treatment of Kidney and Upper Urinary Tract Cancers

Kidney and Upper Tract Urinary Cancers (UTUCs) are diseases of increasing population coverage, the treatment of which is undergoing a continuous process of evolution. A characteristic feature of renal cell cancer (RCC) treatment is the significant heterogeneity of patients (including different stage...

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Médium: Online
Jazyk:angličtina
Vydáno: MDPI - Multidisciplinary Digital Publishing Institute 2024
Témata:
renal cell carcinoma
risk models
survival analysis
charlson comorbidity index
systemic inflammatory markers
upper tract urothelial carcinoma
UTUC
sPD-L1
soluble programmed death ligand-1
biomarker
prognosis
immune checkpoint inhibitor therapy
chemotherapy
radical nephroureterectomy
focal therapy
kidney cancer
thermal ablation
renal carcinoma
RCC
PD-1
PD-L1
nivolumab
kidney tumor
systemic inflammatory response syndrome
nephrectomy
globotriaosylceramide
rhamnose-binding lectin
sunitinib
brain metastases
neurosurgery
targeted therapy
basement membrane
diagnostic
renal cancer
lncRNA
prognostic model
immunotherapy
prostate cancer
transplant
immunosuppression
progression
metastatic prostate cancer
upper tract urothelial cancer
Balkan endemic nephropathy
morphology
CKs
CD44
tyrosine kinase inhibitors (TKI)
cabozantinib
metastatic renal cell carcinoma (mRCC)
adverse events
predictive factor
n/a
thema EDItEUR::P Mathematics and Science::PB Mathematics::PBW Applied mathematics
On-line přístup:ONIX_20240514_9783725805532_307
Tagy: Přidat tag
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Shrnutí:Kidney and Upper Tract Urinary Cancers (UTUCs) are diseases of increasing population coverage, the treatment of which is undergoing a continuous process of evolution. A characteristic feature of renal cell cancer (RCC) treatment is the significant heterogeneity of patients (including different stages of local advancement and different locations of metastases). Importantly, it is estimated that up to 30% of newly diagnosed RCC cases are patients with disseminated disease at the time of diagnosis. Therefore, predicting the response to modern treatment remains the unmet need of modern urologic oncology. Recent advancements in systematic treatment, i.e., immunotherapy, shed additional light on adjuvant treatment to be implemented in new clinical scenarios, including localized disease.

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