Molecular Biology of Colorectal Cancers
Colorectal cancer (CRC) was one of the first tumors in which the molecular mechanisms of carcinogenesis were investigated and confirmed. We now recognize that tumors appearing identical under microscopic examination exhibit molecular differences, and this explains the diverse patient outcomes common...
में बचाया:
| स्वरूप: | Online |
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| भाषा: | अंग्रेज़ी |
| प्रकाशित: |
MDPI - Multidisciplinary Digital Publishing Institute
2024
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| विषय: | |
| ऑनलाइन पहुंच: | ONIX_20240514_9783725804276_351 |
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कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!
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| _version_ | 1869526138222542848 |
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| collection | Directory of Open Access Books |
| description | Colorectal cancer (CRC) was one of the first tumors in which the molecular mechanisms of carcinogenesis were investigated and confirmed. We now recognize that tumors appearing identical under microscopic examination exhibit molecular differences, and this explains the diverse patient outcomes commonly encountered in clinical practice. Despite their similar appearance, cancers are inherently distinct. However, even in the era of molecular medicine and targeted therapies, the majority of patients with metastatic CRC ultimately succumb to the disease, experiencing a diminished quality of life and a significant number of years of potential life lost. This is especially true as younger individuals increasingly fall victim to this illness. Much remains to be understood regarding the mechanisms contributing to the carcinogenesis and temporal evolution of CRC. This Special Issue is dedicated to recent research exploring the molecular mechanisms underlying CRC, encompassing multi-omics analyses and environmental interactions with diagnostic, prognostic, or predictive value. A fascinating world is open to research, and we hope to shed further light on the biology of this common yet still lethal tumor. We are delighted to embark on this journey with our colleagues, as today's scientific progress relies on collaboration between clinicians and basic scientists. We hope you enjoy this Special Issue. |
| format | Online |
| id | doab-20.500.12854ir-137755 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1377552024-05-14T14:21:36Z Molecular Biology of Colorectal Cancers Fernández Aceñero, María Jesús Barderas Manchado, Rodrigo Useros, Javier Martínez Díaz del Arco, Cristina colorectal cancer microRNAs microarray gene-expression profiling molecular classification prognostic factors flow cytometry immunophenotype diagnostic model differentially expressed genes microbiome 16S rRNA sequencing screening diagnosis signaling pathways chemoresistance epithelial-to-mesenchymal transition organoids UBQLN1 ERK-c-Myc pathway cancer progression microRNA prognosis biomarker rectal cancer cancer stem cells OCT4 oncofetal protein preclinical models bioluminescence imaging cell lines spheroids xenograft tumors CMS classification cell proliferation genetic and epigenetic markers cell cycle-related antigens prognostic markers cyclins PCNA Ki-67 antigen ncRNAs immunohistochemistry qRT-PCR RNA/DNA sequencing ABCC4 ABCG2 CRC immune cell infiltration metastasis CRC subpopulations CRC diagnostic and prognostic biomarkers thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues Colorectal cancer (CRC) was one of the first tumors in which the molecular mechanisms of carcinogenesis were investigated and confirmed. We now recognize that tumors appearing identical under microscopic examination exhibit molecular differences, and this explains the diverse patient outcomes commonly encountered in clinical practice. Despite their similar appearance, cancers are inherently distinct. However, even in the era of molecular medicine and targeted therapies, the majority of patients with metastatic CRC ultimately succumb to the disease, experiencing a diminished quality of life and a significant number of years of potential life lost. This is especially true as younger individuals increasingly fall victim to this illness. Much remains to be understood regarding the mechanisms contributing to the carcinogenesis and temporal evolution of CRC. This Special Issue is dedicated to recent research exploring the molecular mechanisms underlying CRC, encompassing multi-omics analyses and environmental interactions with diagnostic, prognostic, or predictive value. A fascinating world is open to research, and we hope to shed further light on the biology of this common yet still lethal tumor. We are delighted to embark on this journey with our colleagues, as today's scientific progress relies on collaboration between clinicians and basic scientists. We hope you enjoy this Special Issue. 2024-05-14T14:21:22Z 2024-05-14T14:21:22Z 2024 book ONIX_20240514_9783725804276_351 9783725804276 9783725804283 https://directory.doabooks.org/handle/20.500.12854/137755 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/8988 https://mdpi.com/books/pdfview/book/8988 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-0428-3 10.3390/books978-3-7258-0428-3 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725804276 9783725804283 206 open access |
| spellingShingle | colorectal cancer microRNAs microarray gene-expression profiling molecular classification prognostic factors flow cytometry immunophenotype diagnostic model differentially expressed genes microbiome 16S rRNA sequencing screening diagnosis signaling pathways chemoresistance epithelial-to-mesenchymal transition organoids UBQLN1 ERK-c-Myc pathway cancer progression microRNA prognosis biomarker rectal cancer cancer stem cells OCT4 oncofetal protein preclinical models bioluminescence imaging cell lines spheroids xenograft tumors CMS classification cell proliferation genetic and epigenetic markers cell cycle-related antigens prognostic markers cyclins PCNA Ki-67 antigen ncRNAs immunohistochemistry qRT-PCR RNA/DNA sequencing ABCC4 ABCG2 CRC immune cell infiltration metastasis CRC subpopulations CRC diagnostic and prognostic biomarkers thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues Molecular Biology of Colorectal Cancers |
| title | Molecular Biology of Colorectal Cancers |
| title_full | Molecular Biology of Colorectal Cancers |
| title_fullStr | Molecular Biology of Colorectal Cancers |
| title_full_unstemmed | Molecular Biology of Colorectal Cancers |
| title_short | Molecular Biology of Colorectal Cancers |
| title_sort | molecular biology of colorectal cancers |
| topic | colorectal cancer microRNAs microarray gene-expression profiling molecular classification prognostic factors flow cytometry immunophenotype diagnostic model differentially expressed genes microbiome 16S rRNA sequencing screening diagnosis signaling pathways chemoresistance epithelial-to-mesenchymal transition organoids UBQLN1 ERK-c-Myc pathway cancer progression microRNA prognosis biomarker rectal cancer cancer stem cells OCT4 oncofetal protein preclinical models bioluminescence imaging cell lines spheroids xenograft tumors CMS classification cell proliferation genetic and epigenetic markers cell cycle-related antigens prognostic markers cyclins PCNA Ki-67 antigen ncRNAs immunohistochemistry qRT-PCR RNA/DNA sequencing ABCC4 ABCG2 CRC immune cell infiltration metastasis CRC subpopulations CRC diagnostic and prognostic biomarkers thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues |
| topic_facet | colorectal cancer microRNAs microarray gene-expression profiling molecular classification prognostic factors flow cytometry immunophenotype diagnostic model differentially expressed genes microbiome 16S rRNA sequencing screening diagnosis signaling pathways chemoresistance epithelial-to-mesenchymal transition organoids UBQLN1 ERK-c-Myc pathway cancer progression microRNA prognosis biomarker rectal cancer cancer stem cells OCT4 oncofetal protein preclinical models bioluminescence imaging cell lines spheroids xenograft tumors CMS classification cell proliferation genetic and epigenetic markers cell cycle-related antigens prognostic markers cyclins PCNA Ki-67 antigen ncRNAs immunohistochemistry qRT-PCR RNA/DNA sequencing ABCC4 ABCG2 CRC immune cell infiltration metastasis CRC subpopulations CRC diagnostic and prognostic biomarkers thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues |
| url | ONIX_20240514_9783725804276_351 |