Non-invasive Device-Mediated Brain Drug Delivery across the Blood-Brain Barrier
It is well known that the blood–brain barrier (BBB), substantially composed of tight junctions between the capillary endothelial cells and efflux transporters such as MDR1 at the apical membrane of the capillary endothelial cells, prevents drugs from entering the brain. Accordingly, drug delivery in...
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| Język: | angielski |
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MDPI - Multidisciplinary Digital Publishing Institute
2024
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| Dostęp online: | ONIX_20240514_9783725806805_428 |
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| collection | Directory of Open Access Books |
| description | It is well known that the blood–brain barrier (BBB), substantially composed of tight junctions between the capillary endothelial cells and efflux transporters such as MDR1 at the apical membrane of the capillary endothelial cells, prevents drugs from entering the brain. Accordingly, drug delivery into the brain across the BBB is a challenging task, particularly in central nervous system diseases such as Alzheimer’s disease and Parkinson’s disease, as well as brain cancers such as glioma. It is true that drugs in systemic circulation go through intentional membrane disruption or intentional tight junction disruption into the brain across the BBB, but bystander harmful compounds can enter the brain together. Moreover, although craniotomy is often conducted for surgical removal or direct drug administration, this process burdens and torments patients. Thus, non-invasive, device-mediated brain drug delivery across the BBB should be developed to improve not only patient health, but also quality of life. At present, brain drug delivery systems that utilize biological transport machineries such as carrier-mediated transport, receptor-mediated transcytosis, lipid-raft-mediated transcytosis, or macropinocytosis at the BBB have been extensively investigated. This Special Issue aims to share recent progress and trends in this field. |
| format | Online |
| id | doab-20.500.12854ir-137832 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1378322024-05-14T14:38:18Z Non-invasive Device-Mediated Brain Drug Delivery across the Blood-Brain Barrier Tournier, Nicolas Tashima, Toshihiko glioblastoma focused ultrasound blood-brain barrier PET SPECT drug delivery rotigotine lecithin-chitosan hybrid nanoparticles intranasal delivery nose-to-brain uptake brain distribution study in vitro model blood–brain barrier (BBB) nanoparticles targeted receptor-mediated transcytosis ligand conjugation nicotinic acetylcholine receptor nanobody VHH transferrin receptor receptor-mediated transcytosis nanoparticle liposome extracellular vesicle chemotherapy targeted therapy blood–brain barrier brain tumor glioma cell-penetrating peptides (CPPs) endosomal entrapment homing peptides tumour-specific markers siRNA-CPP delivery porous silicon nanoparticles BBB-on-a-chip ligand density organ-on-a-chip nanomedicine microfluidic model neurodegenerative disorders non-invasive delivery device-related delivery Alzheimer’s disease Parkinson’s disease ALS Down syndrome CNS disorders nasal delivery biologics nose-to-brain the blood–brain barrier mesenchymal stem cell-based drug delivery transmembrane drug delivery n/a thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TD Industrial chemistry and manufacturing technologies::TDC Industrial chemistry and chemical engineering::TDCW Pharmaceutical chemistry and technology It is well known that the blood–brain barrier (BBB), substantially composed of tight junctions between the capillary endothelial cells and efflux transporters such as MDR1 at the apical membrane of the capillary endothelial cells, prevents drugs from entering the brain. Accordingly, drug delivery into the brain across the BBB is a challenging task, particularly in central nervous system diseases such as Alzheimer’s disease and Parkinson’s disease, as well as brain cancers such as glioma. It is true that drugs in systemic circulation go through intentional membrane disruption or intentional tight junction disruption into the brain across the BBB, but bystander harmful compounds can enter the brain together. Moreover, although craniotomy is often conducted for surgical removal or direct drug administration, this process burdens and torments patients. Thus, non-invasive, device-mediated brain drug delivery across the BBB should be developed to improve not only patient health, but also quality of life. At present, brain drug delivery systems that utilize biological transport machineries such as carrier-mediated transport, receptor-mediated transcytosis, lipid-raft-mediated transcytosis, or macropinocytosis at the BBB have been extensively investigated. This Special Issue aims to share recent progress and trends in this field. 2024-05-14T14:38:06Z 2024-05-14T14:38:06Z 2024 book ONIX_20240514_9783725806805_428 9783725806805 9783725806799 https://directory.doabooks.org/handle/20.500.12854/137832 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/9070 https://mdpi.com/books/pdfview/book/9070 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-0679-9 10.3390/books978-3-7258-0679-9 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725806805 9783725806799 244 open access |
| spellingShingle | glioblastoma focused ultrasound blood-brain barrier PET SPECT drug delivery rotigotine lecithin-chitosan hybrid nanoparticles intranasal delivery nose-to-brain uptake brain distribution study in vitro model blood–brain barrier (BBB) nanoparticles targeted receptor-mediated transcytosis ligand conjugation nicotinic acetylcholine receptor nanobody VHH transferrin receptor receptor-mediated transcytosis nanoparticle liposome extracellular vesicle chemotherapy targeted therapy blood–brain barrier brain tumor glioma cell-penetrating peptides (CPPs) endosomal entrapment homing peptides tumour-specific markers siRNA-CPP delivery porous silicon nanoparticles BBB-on-a-chip ligand density organ-on-a-chip nanomedicine microfluidic model neurodegenerative disorders non-invasive delivery device-related delivery Alzheimer’s disease Parkinson’s disease ALS Down syndrome CNS disorders nasal delivery biologics nose-to-brain the blood–brain barrier mesenchymal stem cell-based drug delivery transmembrane drug delivery n/a thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TD Industrial chemistry and manufacturing technologies::TDC Industrial chemistry and chemical engineering::TDCW Pharmaceutical chemistry and technology Non-invasive Device-Mediated Brain Drug Delivery across the Blood-Brain Barrier |
| title | Non-invasive Device-Mediated Brain Drug Delivery across the Blood-Brain Barrier |
| title_full | Non-invasive Device-Mediated Brain Drug Delivery across the Blood-Brain Barrier |
| title_fullStr | Non-invasive Device-Mediated Brain Drug Delivery across the Blood-Brain Barrier |
| title_full_unstemmed | Non-invasive Device-Mediated Brain Drug Delivery across the Blood-Brain Barrier |
| title_short | Non-invasive Device-Mediated Brain Drug Delivery across the Blood-Brain Barrier |
| title_sort | non invasive device mediated brain drug delivery across the blood brain barrier |
| topic | glioblastoma focused ultrasound blood-brain barrier PET SPECT drug delivery rotigotine lecithin-chitosan hybrid nanoparticles intranasal delivery nose-to-brain uptake brain distribution study in vitro model blood–brain barrier (BBB) nanoparticles targeted receptor-mediated transcytosis ligand conjugation nicotinic acetylcholine receptor nanobody VHH transferrin receptor receptor-mediated transcytosis nanoparticle liposome extracellular vesicle chemotherapy targeted therapy blood–brain barrier brain tumor glioma cell-penetrating peptides (CPPs) endosomal entrapment homing peptides tumour-specific markers siRNA-CPP delivery porous silicon nanoparticles BBB-on-a-chip ligand density organ-on-a-chip nanomedicine microfluidic model neurodegenerative disorders non-invasive delivery device-related delivery Alzheimer’s disease Parkinson’s disease ALS Down syndrome CNS disorders nasal delivery biologics nose-to-brain the blood–brain barrier mesenchymal stem cell-based drug delivery transmembrane drug delivery n/a thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TD Industrial chemistry and manufacturing technologies::TDC Industrial chemistry and chemical engineering::TDCW Pharmaceutical chemistry and technology |
| topic_facet | glioblastoma focused ultrasound blood-brain barrier PET SPECT drug delivery rotigotine lecithin-chitosan hybrid nanoparticles intranasal delivery nose-to-brain uptake brain distribution study in vitro model blood–brain barrier (BBB) nanoparticles targeted receptor-mediated transcytosis ligand conjugation nicotinic acetylcholine receptor nanobody VHH transferrin receptor receptor-mediated transcytosis nanoparticle liposome extracellular vesicle chemotherapy targeted therapy blood–brain barrier brain tumor glioma cell-penetrating peptides (CPPs) endosomal entrapment homing peptides tumour-specific markers siRNA-CPP delivery porous silicon nanoparticles BBB-on-a-chip ligand density organ-on-a-chip nanomedicine microfluidic model neurodegenerative disorders non-invasive delivery device-related delivery Alzheimer’s disease Parkinson’s disease ALS Down syndrome CNS disorders nasal delivery biologics nose-to-brain the blood–brain barrier mesenchymal stem cell-based drug delivery transmembrane drug delivery n/a thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TD Industrial chemistry and manufacturing technologies::TDC Industrial chemistry and chemical engineering::TDCW Pharmaceutical chemistry and technology |
| url | ONIX_20240514_9783725806805_428 |