Neurodegeneration in Cognitive Impairment and Mood Disorders for Experimental, Clinical and Translational Neuropsychiatry
Neurodegeneration is a major problem in neuroscience and medicine, as it causes and worsens many neurological and psychiatric disorders. It involves gradually losing neurons at different brain levels, affecting cognition, emotion, behavior, consciousness, and attention. However, the current therapie...
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| Formato: | Online |
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| Idioma: | inglês |
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MDPI - Multidisciplinary Digital Publishing Institute
2024
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| Acesso em linha: | ONIX_20240514_9783725808595_471 |
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| description | Neurodegeneration is a major problem in neuroscience and medicine, as it causes and worsens many neurological and psychiatric disorders. It involves gradually losing neurons at different brain levels, affecting cognition, emotion, behavior, consciousness, and attention. However, the current therapies are mostly symptomatic and ineffective. In light of these limitations, there is an urgent need to develop novel and transformative approaches, among which non-invasive brain stimulation (NIBS) holds considerable promise. NIBS techniques can modulate neural activity and safely and reversibly promote plasticity, presenting an avenue for exploring innovative treatment modalities. Moreover, the NIBS field is evolving rapidly, with ongoing research endeavors to elucidate its mechanisms of action, identify new clinical applications, and investigate synergistic interactions with pharmacological agents. This Special Issue covers the latest progress and challenges in studying neurodegeneration in cognitive impairment and mood disorders from experimental, clinical, and translational perspectives. It addresses the complexities and diversity of these conditions, the scarcity of disease-modifying treatments, the ethical and practical challenges of conducting research in the development and validation of novel methods such as NIBS, artificial intelligence, and drug repurposing. Collaborative efforts among various stakeholders are needed to improve our knowledge and treatment of neurodegenerative, underlying cognitive impairment, and mood disorders. |
| format | Online |
| id | doab-20.500.12854ir-137875 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1378752024-05-14T14:48:08Z Neurodegeneration in Cognitive Impairment and Mood Disorders for Experimental, Clinical and Translational Neuropsychiatry Battaglia, Simone Tanaka, Masaru saliva cortisol biomarker depression prediction level collection methods correction blood doxorubicin drug combination drug repurposing MCF-7 cells SH-SY5Y cells atorvastatin nitrofurantoin anxiety rapid-acting effect essential oil glutamate neurotoxicity neuroinflammation post-traumatic stress disorder dementia Parkinson’s disease β-amyloid inflammation hippocampus white matter integrity genetics astrocyte glial cells xanthine oxidative stress free radicals neurodegenerative caffeine cognition multiple sclerosis processing speed of information attention memory nanoparticles metal neuropsychological tests biomarkers schizophrenia resistant schizophrenia working memory fixation reproduction disorganized symptoms dissociation short-term memory Down syndrome neurodevelopment cognitive impairment comorbidity diagnosis management artificial intelligence machine learning neurological disorders intellectual disability mercury (Hg) autism spectrum disorder (ASD) clinical matrices comprehensive meta-analysis stroke lacunar mendelian randomization analysis antihypertensive agent hypolipidemic agents hypoglycemic agents aging healthy precision medicine genetic association studies preventive medicine cognitive dysfunction neurobehavioural function neurodegenerative diseases learning and memory sensorimotor function locomotion symbiotic cerebral ischemia BDNF TNF-α tMCAO Enterococcus faecium cytokines neuroprotection n/a thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues Neurodegeneration is a major problem in neuroscience and medicine, as it causes and worsens many neurological and psychiatric disorders. It involves gradually losing neurons at different brain levels, affecting cognition, emotion, behavior, consciousness, and attention. However, the current therapies are mostly symptomatic and ineffective. In light of these limitations, there is an urgent need to develop novel and transformative approaches, among which non-invasive brain stimulation (NIBS) holds considerable promise. NIBS techniques can modulate neural activity and safely and reversibly promote plasticity, presenting an avenue for exploring innovative treatment modalities. Moreover, the NIBS field is evolving rapidly, with ongoing research endeavors to elucidate its mechanisms of action, identify new clinical applications, and investigate synergistic interactions with pharmacological agents. This Special Issue covers the latest progress and challenges in studying neurodegeneration in cognitive impairment and mood disorders from experimental, clinical, and translational perspectives. It addresses the complexities and diversity of these conditions, the scarcity of disease-modifying treatments, the ethical and practical challenges of conducting research in the development and validation of novel methods such as NIBS, artificial intelligence, and drug repurposing. Collaborative efforts among various stakeholders are needed to improve our knowledge and treatment of neurodegenerative, underlying cognitive impairment, and mood disorders. 2024-05-14T14:47:58Z 2024-05-14T14:47:58Z 2024 book ONIX_20240514_9783725808595_471 9783725808595 9783725808601 https://directory.doabooks.org/handle/20.500.12854/137875 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/9116 https://mdpi.com/books/pdfview/book/9116 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-0860-1 10.3390/books978-3-7258-0860-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725808595 9783725808601 232 open access |
| spellingShingle | saliva cortisol biomarker depression prediction level collection methods correction blood doxorubicin drug combination drug repurposing MCF-7 cells SH-SY5Y cells atorvastatin nitrofurantoin anxiety rapid-acting effect essential oil glutamate neurotoxicity neuroinflammation post-traumatic stress disorder dementia Parkinson’s disease β-amyloid inflammation hippocampus white matter integrity genetics astrocyte glial cells xanthine oxidative stress free radicals neurodegenerative caffeine cognition multiple sclerosis processing speed of information attention memory nanoparticles metal neuropsychological tests biomarkers schizophrenia resistant schizophrenia working memory fixation reproduction disorganized symptoms dissociation short-term memory Down syndrome neurodevelopment cognitive impairment comorbidity diagnosis management artificial intelligence machine learning neurological disorders intellectual disability mercury (Hg) autism spectrum disorder (ASD) clinical matrices comprehensive meta-analysis stroke lacunar mendelian randomization analysis antihypertensive agent hypolipidemic agents hypoglycemic agents aging healthy precision medicine genetic association studies preventive medicine cognitive dysfunction neurobehavioural function neurodegenerative diseases learning and memory sensorimotor function locomotion symbiotic cerebral ischemia BDNF TNF-α tMCAO Enterococcus faecium cytokines neuroprotection n/a thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues Neurodegeneration in Cognitive Impairment and Mood Disorders for Experimental, Clinical and Translational Neuropsychiatry |
| title | Neurodegeneration in Cognitive Impairment and Mood Disorders for Experimental, Clinical and Translational Neuropsychiatry |
| title_full | Neurodegeneration in Cognitive Impairment and Mood Disorders for Experimental, Clinical and Translational Neuropsychiatry |
| title_fullStr | Neurodegeneration in Cognitive Impairment and Mood Disorders for Experimental, Clinical and Translational Neuropsychiatry |
| title_full_unstemmed | Neurodegeneration in Cognitive Impairment and Mood Disorders for Experimental, Clinical and Translational Neuropsychiatry |
| title_short | Neurodegeneration in Cognitive Impairment and Mood Disorders for Experimental, Clinical and Translational Neuropsychiatry |
| title_sort | neurodegeneration in cognitive impairment and mood disorders for experimental clinical and translational neuropsychiatry |
| topic | saliva cortisol biomarker depression prediction level collection methods correction blood doxorubicin drug combination drug repurposing MCF-7 cells SH-SY5Y cells atorvastatin nitrofurantoin anxiety rapid-acting effect essential oil glutamate neurotoxicity neuroinflammation post-traumatic stress disorder dementia Parkinson’s disease β-amyloid inflammation hippocampus white matter integrity genetics astrocyte glial cells xanthine oxidative stress free radicals neurodegenerative caffeine cognition multiple sclerosis processing speed of information attention memory nanoparticles metal neuropsychological tests biomarkers schizophrenia resistant schizophrenia working memory fixation reproduction disorganized symptoms dissociation short-term memory Down syndrome neurodevelopment cognitive impairment comorbidity diagnosis management artificial intelligence machine learning neurological disorders intellectual disability mercury (Hg) autism spectrum disorder (ASD) clinical matrices comprehensive meta-analysis stroke lacunar mendelian randomization analysis antihypertensive agent hypolipidemic agents hypoglycemic agents aging healthy precision medicine genetic association studies preventive medicine cognitive dysfunction neurobehavioural function neurodegenerative diseases learning and memory sensorimotor function locomotion symbiotic cerebral ischemia BDNF TNF-α tMCAO Enterococcus faecium cytokines neuroprotection n/a thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues |
| topic_facet | saliva cortisol biomarker depression prediction level collection methods correction blood doxorubicin drug combination drug repurposing MCF-7 cells SH-SY5Y cells atorvastatin nitrofurantoin anxiety rapid-acting effect essential oil glutamate neurotoxicity neuroinflammation post-traumatic stress disorder dementia Parkinson’s disease β-amyloid inflammation hippocampus white matter integrity genetics astrocyte glial cells xanthine oxidative stress free radicals neurodegenerative caffeine cognition multiple sclerosis processing speed of information attention memory nanoparticles metal neuropsychological tests biomarkers schizophrenia resistant schizophrenia working memory fixation reproduction disorganized symptoms dissociation short-term memory Down syndrome neurodevelopment cognitive impairment comorbidity diagnosis management artificial intelligence machine learning neurological disorders intellectual disability mercury (Hg) autism spectrum disorder (ASD) clinical matrices comprehensive meta-analysis stroke lacunar mendelian randomization analysis antihypertensive agent hypolipidemic agents hypoglycemic agents aging healthy precision medicine genetic association studies preventive medicine cognitive dysfunction neurobehavioural function neurodegenerative diseases learning and memory sensorimotor function locomotion symbiotic cerebral ischemia BDNF TNF-α tMCAO Enterococcus faecium cytokines neuroprotection n/a thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues |
| url | ONIX_20240514_9783725808595_471 |