microRNAs in Health and Disease
This Special Issue delves into the intricate world of miRNAs as modulators of gene expression regulation. These small non-coding RNAs are at the heart of post-transcriptional modulation of gene activity, affecting a myriad of biological processes. The curated selection of articles within this issue...
Sábháilte in:
| Formáid: | Online |
|---|---|
| Teanga: | Béarla |
| Foilsithe / Cruthaithe: |
MDPI - Multidisciplinary Digital Publishing Institute
2024
|
| Ábhair: | |
| Rochtain ar líne: | ONIX_20240514_9783725808434_532 |
| Clibeanna: |
Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!
|
| _version_ | 1869523198733713408 |
|---|---|
| collection | Directory of Open Access Books |
| description | This Special Issue delves into the intricate world of miRNAs as modulators of gene expression regulation. These small non-coding RNAs are at the heart of post-transcriptional modulation of gene activity, affecting a myriad of biological processes. The curated selection of articles within this issue offers insights into the roles of miRNAs in health and disease, emphasizing their potential value as therapeutic targets and biomarkers. Featuring original research and in depth-reviews, this Special Issue covers recent miRNA advancements, detailing their regulatory networks and action mechanisms. It highlights new miRNA-linked therapeutic targets and circulating miRNAs as cell-to-cell communication intermediaries. The issue also examines extracellular miRNAs (ex-miRNAs) and their functions, highlighting their presence in biological fluids and their potential utility in clinical diagnostics and disease monitoring. Challenges in miRNA quantification and technological advances for precise measurement are also discussed. The issue traverses the less-charted territories of miRNA research, such as the discovery of small nucleolar-derived miRNAs and the elucidation of transposable elements as unexpected constituents of the miRNA regulatory network. Overall, this collection showcases the evolving nature of miRNA research, offering valuable perspectives for future scientific inquiry and medical innovation. It reflects the drive to decode gene regulation complexities, providing insights for health professionals and researchers at the forefront of gene regulation research. |
| format | Online |
| id | doab-20.500.12854ir-137917 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1379172024-05-14T14:56:27Z microRNAs in Health and Disease Rizzo, Milena Levantini, Elena miRNA mammary gland lactation obesogenic diet microRNA digital PCR biomarkers extraction-free plasma obesity pregnancy next-generation sequencing cancer gene regulation small nucleolar RNA (snoRNA) small nucleolar derived RNA (sdRNA) microRNA (miRNA) RNA snoRNA sdRNA genetics ALS mouse model anti-microRNA-124 intraspinal delivery route neuroprotection prevention of glial dysfunction preservation of motor performance secretome-based therapy SOD1-G93A mutation miR-29 biomarker therapeutic target recurrent pregnancy loss single-nucleotide polymorphism (SNP) extracellular vesicles biogenesis cargo sorting tissue repair and regeneration uterine leiomyosarcoma endometrial stromal sarcoma epigenetics mechanisms ncRNA DNA methylation histones modifications arrhythmogenic cardiomyopathy lncRNA circRNA pseudogene ceRNA Wnt/β-catenin pathway Hippo pathway microRNAs1 hippocampus hypoxia transposons LINE1 p53 pediatric cancer human breast milk polymerase chain reaction (PCR) microRNA characterization ovarian cancer saliva urine ascites blood biofluids early diagnosis screening intracerebral hemorrhage aging RNA medicine breast cancer actinic keratosis cSCC n/a thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues This Special Issue delves into the intricate world of miRNAs as modulators of gene expression regulation. These small non-coding RNAs are at the heart of post-transcriptional modulation of gene activity, affecting a myriad of biological processes. The curated selection of articles within this issue offers insights into the roles of miRNAs in health and disease, emphasizing their potential value as therapeutic targets and biomarkers. Featuring original research and in depth-reviews, this Special Issue covers recent miRNA advancements, detailing their regulatory networks and action mechanisms. It highlights new miRNA-linked therapeutic targets and circulating miRNAs as cell-to-cell communication intermediaries. The issue also examines extracellular miRNAs (ex-miRNAs) and their functions, highlighting their presence in biological fluids and their potential utility in clinical diagnostics and disease monitoring. Challenges in miRNA quantification and technological advances for precise measurement are also discussed. The issue traverses the less-charted territories of miRNA research, such as the discovery of small nucleolar-derived miRNAs and the elucidation of transposable elements as unexpected constituents of the miRNA regulatory network. Overall, this collection showcases the evolving nature of miRNA research, offering valuable perspectives for future scientific inquiry and medical innovation. It reflects the drive to decode gene regulation complexities, providing insights for health professionals and researchers at the forefront of gene regulation research. 2024-05-14T14:56:22Z 2024-05-14T14:56:22Z 2024 book ONIX_20240514_9783725808434_532 9783725808434 9783725808441 https://directory.doabooks.org/handle/20.500.12854/137917 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/9181 https://mdpi.com/books/pdfview/book/9181 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-0844-1 10.3390/books978-3-7258-0844-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725808434 9783725808441 330 open access |
| spellingShingle | miRNA mammary gland lactation obesogenic diet microRNA digital PCR biomarkers extraction-free plasma obesity pregnancy next-generation sequencing cancer gene regulation small nucleolar RNA (snoRNA) small nucleolar derived RNA (sdRNA) microRNA (miRNA) RNA snoRNA sdRNA genetics ALS mouse model anti-microRNA-124 intraspinal delivery route neuroprotection prevention of glial dysfunction preservation of motor performance secretome-based therapy SOD1-G93A mutation miR-29 biomarker therapeutic target recurrent pregnancy loss single-nucleotide polymorphism (SNP) extracellular vesicles biogenesis cargo sorting tissue repair and regeneration uterine leiomyosarcoma endometrial stromal sarcoma epigenetics mechanisms ncRNA DNA methylation histones modifications arrhythmogenic cardiomyopathy lncRNA circRNA pseudogene ceRNA Wnt/β-catenin pathway Hippo pathway microRNAs1 hippocampus hypoxia transposons LINE1 p53 pediatric cancer human breast milk polymerase chain reaction (PCR) microRNA characterization ovarian cancer saliva urine ascites blood biofluids early diagnosis screening intracerebral hemorrhage aging RNA medicine breast cancer actinic keratosis cSCC n/a thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues microRNAs in Health and Disease |
| title | microRNAs in Health and Disease |
| title_full | microRNAs in Health and Disease |
| title_fullStr | microRNAs in Health and Disease |
| title_full_unstemmed | microRNAs in Health and Disease |
| title_short | microRNAs in Health and Disease |
| title_sort | micrornas in health and disease |
| topic | miRNA mammary gland lactation obesogenic diet microRNA digital PCR biomarkers extraction-free plasma obesity pregnancy next-generation sequencing cancer gene regulation small nucleolar RNA (snoRNA) small nucleolar derived RNA (sdRNA) microRNA (miRNA) RNA snoRNA sdRNA genetics ALS mouse model anti-microRNA-124 intraspinal delivery route neuroprotection prevention of glial dysfunction preservation of motor performance secretome-based therapy SOD1-G93A mutation miR-29 biomarker therapeutic target recurrent pregnancy loss single-nucleotide polymorphism (SNP) extracellular vesicles biogenesis cargo sorting tissue repair and regeneration uterine leiomyosarcoma endometrial stromal sarcoma epigenetics mechanisms ncRNA DNA methylation histones modifications arrhythmogenic cardiomyopathy lncRNA circRNA pseudogene ceRNA Wnt/β-catenin pathway Hippo pathway microRNAs1 hippocampus hypoxia transposons LINE1 p53 pediatric cancer human breast milk polymerase chain reaction (PCR) microRNA characterization ovarian cancer saliva urine ascites blood biofluids early diagnosis screening intracerebral hemorrhage aging RNA medicine breast cancer actinic keratosis cSCC n/a thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues |
| topic_facet | miRNA mammary gland lactation obesogenic diet microRNA digital PCR biomarkers extraction-free plasma obesity pregnancy next-generation sequencing cancer gene regulation small nucleolar RNA (snoRNA) small nucleolar derived RNA (sdRNA) microRNA (miRNA) RNA snoRNA sdRNA genetics ALS mouse model anti-microRNA-124 intraspinal delivery route neuroprotection prevention of glial dysfunction preservation of motor performance secretome-based therapy SOD1-G93A mutation miR-29 biomarker therapeutic target recurrent pregnancy loss single-nucleotide polymorphism (SNP) extracellular vesicles biogenesis cargo sorting tissue repair and regeneration uterine leiomyosarcoma endometrial stromal sarcoma epigenetics mechanisms ncRNA DNA methylation histones modifications arrhythmogenic cardiomyopathy lncRNA circRNA pseudogene ceRNA Wnt/β-catenin pathway Hippo pathway microRNAs1 hippocampus hypoxia transposons LINE1 p53 pediatric cancer human breast milk polymerase chain reaction (PCR) microRNA characterization ovarian cancer saliva urine ascites blood biofluids early diagnosis screening intracerebral hemorrhage aging RNA medicine breast cancer actinic keratosis cSCC n/a thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues |
| url | ONIX_20240514_9783725808434_532 |