Craniofacial Development and Growth in Polycystic Kidney Disease
Autosomal dominant polycystic kidney disease (ADPKD) is an inherited disorder characterized by the presence of multiple cysts in kidneys. ADPKD has been shown to be caused by mutations in the genes of PKD1 and PKD2, encoding polycystin-1 (PC1) and polycystin-2 (PC2), respectively. Polycystins are lo...
Na minha lista:
| Formato: | Online |
|---|---|
| Idioma: | inglês |
| Publicado em: |
Exon Publications
2024
|
| Assuntos: | |
| Acesso em linha: | https://directory.doabooks.org/handle/20.500.12854/138175 |
| Tags: |
Sem tags, seja o primeiro a adicionar uma tag!
|
| _version_ | 1869517458517262336 |
|---|---|
| collection | Directory of Open Access Books |
| description | Autosomal dominant polycystic kidney disease (ADPKD) is an inherited disorder characterized by the presence of multiple cysts in kidneys. ADPKD has been shown to be caused by mutations in the genes of PKD1 and PKD2, encoding polycystin-1 (PC1) and polycystin-2 (PC2), respectively. Polycystins are localized in primary cilia that play roles in multiple biological processes including mechanoreception, Ca2+ influx and cell signalling pathways. Primary cilia are known to play important roles in regulating craniofacial development and growth. In this chapter, we summarize the function of Pkd1 and Pkd2 in controlling mouse craniofacial development and growth, and discuss PKD-associated molecular mechanisms. |
| format | Online |
| id | doab-20.500.12854ir-138175 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Exon Publications |
| publisherStr | Exon Publications |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1381752024-05-21T23:53:17Z Craniofacial Development and Growth in Polycystic Kidney Disease Craniofacial Development Polycystic Kidney Disease MJR Autosomal dominant polycystic kidney disease (ADPKD) is an inherited disorder characterized by the presence of multiple cysts in kidneys. ADPKD has been shown to be caused by mutations in the genes of PKD1 and PKD2, encoding polycystin-1 (PC1) and polycystin-2 (PC2), respectively. Polycystins are localized in primary cilia that play roles in multiple biological processes including mechanoreception, Ca2+ influx and cell signalling pathways. Primary cilia are known to play important roles in regulating craniofacial development and growth. In this chapter, we summarize the function of Pkd1 and Pkd2 in controlling mouse craniofacial development and growth, and discuss PKD-associated molecular mechanisms. Published 2024-05-21T23:53:12Z 2024-05-21T23:53:12Z 2015-11-18 chapter 978-0-9944381-0-2 https://directory.doabooks.org/handle/20.500.12854/138175 eng image/jpeg Attribution-NonCommercial-NoDerivatives 4.0 International https://exonpublications.com/index.php/exon/article/view/87 Exon Publications Polycystic Kidney Disease 10.15586/codon.pkd.2015.ch19 10.15586/codon.pkd.2015.ch19 2d6001a3-9e06-4979-bf02-6974e313eb24 01173f6b-d01d-49c3-b18e-93cfe3a0383d 978-0-9944381-0-2 457-470 Brisbane(AU) open access |
| spellingShingle | Craniofacial Development Polycystic Kidney Disease MJR Craniofacial Development and Growth in Polycystic Kidney Disease |
| title | Craniofacial Development and Growth in Polycystic Kidney Disease |
| title_full | Craniofacial Development and Growth in Polycystic Kidney Disease |
| title_fullStr | Craniofacial Development and Growth in Polycystic Kidney Disease |
| title_full_unstemmed | Craniofacial Development and Growth in Polycystic Kidney Disease |
| title_short | Craniofacial Development and Growth in Polycystic Kidney Disease |
| title_sort | craniofacial development and growth in polycystic kidney disease |
| topic | Craniofacial Development Polycystic Kidney Disease MJR |
| topic_facet | Craniofacial Development Polycystic Kidney Disease MJR |
| url | https://directory.doabooks.org/handle/20.500.12854/138175 |