Porcine Models of Neurotrauma and Neurological Disorders
The translation of therapeutics from the lab to the clinic has a dismal record in the fields of neurotrauma and neurological disorders. This is due, in part, to the challenging heterogeneity of the clinical population common to all translational research, but it is also due to the unique challenges...
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| Natura: | Online |
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| Lingua: | inglese |
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MDPI - Multidisciplinary Digital Publishing Institute
2024
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| Accesso online: | ONIX_20240704_9783725805051_4 |
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| collection | Directory of Open Access Books |
| description | The translation of therapeutics from the lab to the clinic has a dismal record in the fields of neurotrauma and neurological disorders. This is due, in part, to the challenging heterogeneity of the clinical population common to all translational research, but it is also due to the unique challenges of recreating the mechanisms and manifestations of human neurological injury/disorders in small animals. Large animal models are an essential component of successful pipelines for moving discoveries from bench to bedside in other fields (e.g., exploring device or therapeutic scale-up and/or IND/IDE enabling studies), and neuroscience has made significant progress toward establishing such pipelines in its many unique subfields. Due to their size, gyrencephalic brains, high white matter content, and other factors, swine have proven to be ideal for providing high-fidelity, clinically relevant studies to bridge the gap between small animals and humans. Only by recognizing the strengths and limitations of our models can we hope to effectively develop, validate, and translate novel neuroprotective and regenerative therapeutics into clinical practice, in order to maximize functional recovery. Herein, we provide detailed descriptions of and findings from some of the sophisticated swine model systems that have been developed to empower translational research in neurotrauma and neurological disorders. |
| format | Online |
| id | doab-20.500.12854ir-139208 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1392082024-07-04T09:27:46Z Porcine Models of Neurotrauma and Neurological Disorders O'Donnell, John Petrov, Dmitriy cognition behavior operant brain injury Alzheimer’s disease transgenic concussion gait pediatric swine rapid non-impact head rotation oculomotor animal models mild traumatic brain injury (mTBI) diagnostic methods pupillary light response visual processing porcine acquired brain injury traumatic brain injury coma disorders of consciousness subarachnoid hemorrhage neurocritical care neurointensive care unit multimodal neuromonitoring translational neurotrauma spinal cord injury gastrointestinal motility SmartPill™, wireless motility capsule porcine model axonal injury micro pig diffuse pathology microglia aged tissue tau phosphorylated tau TBI PNT001 brain concussion auditory evoked potentials visually evoked potentials auditory perception visual perception traumatic brain injuries electrodes mild TBI neuroinflammation large animal models fibrinogen neurotrauma translational neuroscience large animal pig physiology porcine models regeneration hemisection contusion balloon compression technique astrocytes glia n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences The translation of therapeutics from the lab to the clinic has a dismal record in the fields of neurotrauma and neurological disorders. This is due, in part, to the challenging heterogeneity of the clinical population common to all translational research, but it is also due to the unique challenges of recreating the mechanisms and manifestations of human neurological injury/disorders in small animals. Large animal models are an essential component of successful pipelines for moving discoveries from bench to bedside in other fields (e.g., exploring device or therapeutic scale-up and/or IND/IDE enabling studies), and neuroscience has made significant progress toward establishing such pipelines in its many unique subfields. Due to their size, gyrencephalic brains, high white matter content, and other factors, swine have proven to be ideal for providing high-fidelity, clinically relevant studies to bridge the gap between small animals and humans. Only by recognizing the strengths and limitations of our models can we hope to effectively develop, validate, and translate novel neuroprotective and regenerative therapeutics into clinical practice, in order to maximize functional recovery. Herein, we provide detailed descriptions of and findings from some of the sophisticated swine model systems that have been developed to empower translational research in neurotrauma and neurological disorders. 2024-07-04T09:27:41Z 2024-07-04T09:27:41Z 2024 book ONIX_20240704_9783725805051_4 9783725805051 9783725805068 https://directory.doabooks.org/handle/20.500.12854/139208 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/9203 https://mdpi.com/books/pdfview/book/9203 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-0506-8 10.3390/books978-3-7258-0506-8 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725805051 9783725805068 236 open access |
| spellingShingle | cognition behavior operant brain injury Alzheimer’s disease transgenic concussion gait pediatric swine rapid non-impact head rotation oculomotor animal models mild traumatic brain injury (mTBI) diagnostic methods pupillary light response visual processing porcine acquired brain injury traumatic brain injury coma disorders of consciousness subarachnoid hemorrhage neurocritical care neurointensive care unit multimodal neuromonitoring translational neurotrauma spinal cord injury gastrointestinal motility SmartPill™, wireless motility capsule porcine model axonal injury micro pig diffuse pathology microglia aged tissue tau phosphorylated tau TBI PNT001 brain concussion auditory evoked potentials visually evoked potentials auditory perception visual perception traumatic brain injuries electrodes mild TBI neuroinflammation large animal models fibrinogen neurotrauma translational neuroscience large animal pig physiology porcine models regeneration hemisection contusion balloon compression technique astrocytes glia n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Porcine Models of Neurotrauma and Neurological Disorders |
| title | Porcine Models of Neurotrauma and Neurological Disorders |
| title_full | Porcine Models of Neurotrauma and Neurological Disorders |
| title_fullStr | Porcine Models of Neurotrauma and Neurological Disorders |
| title_full_unstemmed | Porcine Models of Neurotrauma and Neurological Disorders |
| title_short | Porcine Models of Neurotrauma and Neurological Disorders |
| title_sort | porcine models of neurotrauma and neurological disorders |
| topic | cognition behavior operant brain injury Alzheimer’s disease transgenic concussion gait pediatric swine rapid non-impact head rotation oculomotor animal models mild traumatic brain injury (mTBI) diagnostic methods pupillary light response visual processing porcine acquired brain injury traumatic brain injury coma disorders of consciousness subarachnoid hemorrhage neurocritical care neurointensive care unit multimodal neuromonitoring translational neurotrauma spinal cord injury gastrointestinal motility SmartPill™, wireless motility capsule porcine model axonal injury micro pig diffuse pathology microglia aged tissue tau phosphorylated tau TBI PNT001 brain concussion auditory evoked potentials visually evoked potentials auditory perception visual perception traumatic brain injuries electrodes mild TBI neuroinflammation large animal models fibrinogen neurotrauma translational neuroscience large animal pig physiology porcine models regeneration hemisection contusion balloon compression technique astrocytes glia n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | cognition behavior operant brain injury Alzheimer’s disease transgenic concussion gait pediatric swine rapid non-impact head rotation oculomotor animal models mild traumatic brain injury (mTBI) diagnostic methods pupillary light response visual processing porcine acquired brain injury traumatic brain injury coma disorders of consciousness subarachnoid hemorrhage neurocritical care neurointensive care unit multimodal neuromonitoring translational neurotrauma spinal cord injury gastrointestinal motility SmartPill™, wireless motility capsule porcine model axonal injury micro pig diffuse pathology microglia aged tissue tau phosphorylated tau TBI PNT001 brain concussion auditory evoked potentials visually evoked potentials auditory perception visual perception traumatic brain injuries electrodes mild TBI neuroinflammation large animal models fibrinogen neurotrauma translational neuroscience large animal pig physiology porcine models regeneration hemisection contusion balloon compression technique astrocytes glia n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | ONIX_20240704_9783725805051_4 |