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ADP-Ribosylation in Pathogens

ADP-ribosylation was discovered over 60 years ago, and much of the research focused on bacterial toxins that employed ADP-ribosylation to kill host cells. However, in the last 20 years, the field has identified many cases where host-mediated ADP-ribosylation can either promote or repress pathogenic...

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Gardado en:
Formato: Online
Idioma:inglés
Publicado: MDPI - Multidisciplinary Digital Publishing Institute 2024
Subjects:
coronavirus
alphavirus
SARS-CoV-2
macrodomain
ADP-ribosylation
ADP-ribosylhydrolase
therapeutics
14-3-3 activated bacterial exotoxins
actin
Aeromonas salmonicid
protein refolding
type III secretion system
Pseudomonas aeruginosa
toxin–antitoxin
DarT/DarG
DNA modification
cell growth
phage defence
antimicrobial resistance
PARylation
MARylation
post-translational modifications
viral infection
antiviral response
IFN-I
innate immunity
COVID-19
non-structural protein 3 (NSP3)
drug discovery and development
virtual screening
hydrolase
interferon
PARP
RNA-virus
Legionella pneumophila
SidE family
effector
PR-ubiquitination
host-pathogen interaction
host–virus evolution
phylogenetics
alphaviruses
coronaviruses
PARG
Trypanosoma
Leishmania
poly ADP-ribosylation
Aedes aegypti
tankyrase
chikungunya virus (CHIKV)
immunity
mass spectrometry
proteomics
poly(ADP-ribose) glycohydrolase
Diphtheria toxin-like ADP-ribosyltransferases
chronic infection
arboviruses
cardiovascular disease
emphysema
alcoholic liver disease
host–pathogen interactions
Mac1
inhibitors
PARP1
DNA virus
epigenetic
viral gene regulation
thema EDItEUR::P Mathematics and Science
thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKF Pathology::MKFM Medical microbiology and virology
Acceso en liña:ONIX_20240704_9783725809868_21
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Summary:ADP-ribosylation was discovered over 60 years ago, and much of the research focused on bacterial toxins that employed ADP-ribosylation to kill host cells. However, in the last 20 years, the field has identified many cases where host-mediated ADP-ribosylation can either promote or repress pathogenic infections. It is clear that ADP-ribosylation is a key component of the innate immune response in eukaryotes and bacteria, and many of the mechanistic details of how ADP-ribosylation impacts pathogens have yet to be uncovered. In this Special Issue, we have focused on publishing unique reviews and primary research on the topics of pathogens and ADP-ribosylation. We hope that you will enjoy this collection.

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