Advanced Research in Age-Related Macular Degeneration (AMD)
Age-related macular degeneration (AMD) is the main cause of irreversible vision loss in people over 60 years of age. Due to the aging of the global population in the coming decades, the number of patients with AMD is expected to increase significantly. The pathogenesis of AMD is based on a decrease...
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| Médium: | Online |
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| Jazyk: | angličtina |
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MDPI - Multidisciplinary Digital Publishing Institute
2024
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| On-line přístup: | ONIX_20240704_9783725811779_162 |
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| collection | Directory of Open Access Books |
| description | Age-related macular degeneration (AMD) is the main cause of irreversible vision loss in people over 60 years of age. Due to the aging of the global population in the coming decades, the number of patients with AMD is expected to increase significantly. The pathogenesis of AMD is based on a decrease in the metabolic and regenerative processes characteristic of aging and a violation of the microcirculation and structural organization of the retina, for which the prerequisites and mechanisms of the transition into the pathological process remain unclear. Therefore, studies on the molecular mechanisms of AMD pathogenesis and new approaches to its early diagnostics and treatments are urgently needed. In this Special Issue, authors were invited to contribute original clinical and experimental studies on different aspects related to the theme of “Advanced Research in AMD”. Through these published articles, this Issue provided new insights into the diagnosis and treatment of AMD and has the potential to impact current and future knowledge regarding the pathogenesis and treatment of patients with AMD. New diagnostic approaches and treatment regimens, the development of multimodal visualization methods and the potential genetic and OCT markers of treatment response may help guide the future management of this disease. |
| format | Online |
| id | doab-20.500.12854ir-139366 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1393662024-07-04T09:46:58Z Advanced Research in Age-Related Macular Degeneration (AMD) Kozhevnikova, Oyuna age-related macular degeneration geographic atrophy complement cascade therapeutics clinical trials subretinal drusenoid deposits SDDs reticular pseudodrusen spectral domain optical coherence tomography OCT MNV macular neovascularization CNV AMD diabetes mellitus visual disability c-Jun N-Terminal Kinase Inhibitor IQ-1S OXYS rats quantitative autofluorescence hyperreflective foci drusen bacillary layer detachment neovascular AMD anti-VEGF retinal haemorrhage myoid macula retina intravitreal injections vitelliform lesions optical coherence tomography image analysis ImageJ endpoints statistics autophagy response to anti-VEGF therapy pharmacogenetics aflibercept STAT4 gene polymorphisms n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJQ Ophthalmology Age-related macular degeneration (AMD) is the main cause of irreversible vision loss in people over 60 years of age. Due to the aging of the global population in the coming decades, the number of patients with AMD is expected to increase significantly. The pathogenesis of AMD is based on a decrease in the metabolic and regenerative processes characteristic of aging and a violation of the microcirculation and structural organization of the retina, for which the prerequisites and mechanisms of the transition into the pathological process remain unclear. Therefore, studies on the molecular mechanisms of AMD pathogenesis and new approaches to its early diagnostics and treatments are urgently needed. In this Special Issue, authors were invited to contribute original clinical and experimental studies on different aspects related to the theme of “Advanced Research in AMD”. Through these published articles, this Issue provided new insights into the diagnosis and treatment of AMD and has the potential to impact current and future knowledge regarding the pathogenesis and treatment of patients with AMD. New diagnostic approaches and treatment regimens, the development of multimodal visualization methods and the potential genetic and OCT markers of treatment response may help guide the future management of this disease. 2024-07-04T09:46:56Z 2024-07-04T09:46:56Z 2024 book ONIX_20240704_9783725811779_162 9783725811779 9783725811786 https://directory.doabooks.org/handle/20.500.12854/139366 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/9364 https://mdpi.com/books/pdfview/book/9364 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-1178-6 10.3390/books978-3-7258-1178-6 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725811779 9783725811786 166 open access |
| spellingShingle | age-related macular degeneration geographic atrophy complement cascade therapeutics clinical trials subretinal drusenoid deposits SDDs reticular pseudodrusen spectral domain optical coherence tomography OCT MNV macular neovascularization CNV AMD diabetes mellitus visual disability c-Jun N-Terminal Kinase Inhibitor IQ-1S OXYS rats quantitative autofluorescence hyperreflective foci drusen bacillary layer detachment neovascular AMD anti-VEGF retinal haemorrhage myoid macula retina intravitreal injections vitelliform lesions optical coherence tomography image analysis ImageJ endpoints statistics autophagy response to anti-VEGF therapy pharmacogenetics aflibercept STAT4 gene polymorphisms n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJQ Ophthalmology Advanced Research in Age-Related Macular Degeneration (AMD) |
| title | Advanced Research in Age-Related Macular Degeneration (AMD) |
| title_full | Advanced Research in Age-Related Macular Degeneration (AMD) |
| title_fullStr | Advanced Research in Age-Related Macular Degeneration (AMD) |
| title_full_unstemmed | Advanced Research in Age-Related Macular Degeneration (AMD) |
| title_short | Advanced Research in Age-Related Macular Degeneration (AMD) |
| title_sort | advanced research in age related macular degeneration amd |
| topic | age-related macular degeneration geographic atrophy complement cascade therapeutics clinical trials subretinal drusenoid deposits SDDs reticular pseudodrusen spectral domain optical coherence tomography OCT MNV macular neovascularization CNV AMD diabetes mellitus visual disability c-Jun N-Terminal Kinase Inhibitor IQ-1S OXYS rats quantitative autofluorescence hyperreflective foci drusen bacillary layer detachment neovascular AMD anti-VEGF retinal haemorrhage myoid macula retina intravitreal injections vitelliform lesions optical coherence tomography image analysis ImageJ endpoints statistics autophagy response to anti-VEGF therapy pharmacogenetics aflibercept STAT4 gene polymorphisms n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJQ Ophthalmology |
| topic_facet | age-related macular degeneration geographic atrophy complement cascade therapeutics clinical trials subretinal drusenoid deposits SDDs reticular pseudodrusen spectral domain optical coherence tomography OCT MNV macular neovascularization CNV AMD diabetes mellitus visual disability c-Jun N-Terminal Kinase Inhibitor IQ-1S OXYS rats quantitative autofluorescence hyperreflective foci drusen bacillary layer detachment neovascular AMD anti-VEGF retinal haemorrhage myoid macula retina intravitreal injections vitelliform lesions optical coherence tomography image analysis ImageJ endpoints statistics autophagy response to anti-VEGF therapy pharmacogenetics aflibercept STAT4 gene polymorphisms n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJQ Ophthalmology |
| url | ONIX_20240704_9783725811779_162 |