Molecular Diagnostics of Cancer
Precision medicine, also known as personalized medicine, is an innovative approach to medical treatment and diagnosis that takes into account individual variability in genes, environment, and lifestyle for each person. In the context of cancer, precision medicine aims to tailor medical care to the s...
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| Format: | Online |
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| Język: | angielski |
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IntechOpen
2024
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| Dostęp online: | ONIX_20240711_9781837694334_135 |
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| _version_ | 1869518526391255040 |
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| collection | Directory of Open Access Books |
| description | Precision medicine, also known as personalized medicine, is an innovative approach to medical treatment and diagnosis that takes into account individual variability in genes, environment, and lifestyle for each person. In the context of cancer, precision medicine aims to tailor medical care to the specific genetic and molecular characteristics of each patient's tumor. This allows for more targeted and effective treatments, minimizing side effects and improving outcomes. The first step in precision medicine, especially in oncology, is represented by an accurate diagnosis, including molecular and genetic data. A comprehensive assessment in molecular pathology includes conventional and more innovative techniques, including polymerase chain reaction (PCR)-based approaches, Sanger sequencing, and next-generation sequencing for genomic profiling. Precision medicine relies on the analysis of the patient's genomic information, including the DNA mutations present in their tumor. Genomic profiling helps identify specific genetic alterations that are driving the growth of cancer cells. This information is crucial for selecting targeted therapies that directly interfere with these specific molecular abnormalities. In addition, molecular diagnostics provide: • biomarker identification • tumor heterogeneity assessment In turn, this translates into direct treatment decision support. The information obtained through molecular tests guides oncologists in making more informed decisions about the most appropriate treatments for individual patients. This can include targeted therapies, immunotherapies, or other interventions based on the specific molecular profile of the tumor. Prognostication becomes treatment-specific (prediction) and predictive models can be developed by integrating genetic and molecular data with clinical information, to estimate the likelihood of treatment response, recurrence, and overall prognosis. Overall, molecular pathology has significantly advanced cancer diagnostics and treatment, leading to improved outcomes and a shift toward more personalized and effective care. The integration of molecular diagnostics and genomic information has transformed how cancer is understood and managed, offering new hope for patients and providing oncologists with powerful tools to combat the complexity of the disease. |
| format | Online |
| id | doab-20.500.12854ir-140321 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1403212024-07-11T08:02:37Z Molecular Diagnostics of Cancer Paolo Piccaluga, Pier Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology Precision medicine, also known as personalized medicine, is an innovative approach to medical treatment and diagnosis that takes into account individual variability in genes, environment, and lifestyle for each person. In the context of cancer, precision medicine aims to tailor medical care to the specific genetic and molecular characteristics of each patient's tumor. This allows for more targeted and effective treatments, minimizing side effects and improving outcomes. The first step in precision medicine, especially in oncology, is represented by an accurate diagnosis, including molecular and genetic data. A comprehensive assessment in molecular pathology includes conventional and more innovative techniques, including polymerase chain reaction (PCR)-based approaches, Sanger sequencing, and next-generation sequencing for genomic profiling. Precision medicine relies on the analysis of the patient's genomic information, including the DNA mutations present in their tumor. Genomic profiling helps identify specific genetic alterations that are driving the growth of cancer cells. This information is crucial for selecting targeted therapies that directly interfere with these specific molecular abnormalities. In addition, molecular diagnostics provide: • biomarker identification • tumor heterogeneity assessment In turn, this translates into direct treatment decision support. The information obtained through molecular tests guides oncologists in making more informed decisions about the most appropriate treatments for individual patients. This can include targeted therapies, immunotherapies, or other interventions based on the specific molecular profile of the tumor. Prognostication becomes treatment-specific (prediction) and predictive models can be developed by integrating genetic and molecular data with clinical information, to estimate the likelihood of treatment response, recurrence, and overall prognosis. Overall, molecular pathology has significantly advanced cancer diagnostics and treatment, leading to improved outcomes and a shift toward more personalized and effective care. The integration of molecular diagnostics and genomic information has transformed how cancer is understood and managed, offering new hope for patients and providing oncologists with powerful tools to combat the complexity of the disease. 2024-07-11T08:02:35Z 2024-07-11T08:02:35Z 2024 book ONIX_20240711_9781837694334_135 9781837694334 9781837694341 9781837694358 https://directory.doabooks.org/handle/20.500.12854/140321 eng image/jpeg n/a https://www.intechopen.com/books/1003088 https://intech-files.s3.amazonaws.com/a043Y00000zFsnOQAS/0014992_Authors_Book%20%282024-04-18%2009%3A29%3A54%29.pdf IntechOpen IntechOpen 10.5772/intechopen.111118 10.5772/intechopen.111118 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9781837694334 9781837694341 9781837694358 IntechOpen 284 open access |
| spellingShingle | Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology Molecular Diagnostics of Cancer |
| title | Molecular Diagnostics of Cancer |
| title_full | Molecular Diagnostics of Cancer |
| title_fullStr | Molecular Diagnostics of Cancer |
| title_full_unstemmed | Molecular Diagnostics of Cancer |
| title_short | Molecular Diagnostics of Cancer |
| title_sort | molecular diagnostics of cancer |
| topic | Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology |
| topic_facet | Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology |
| url | ONIX_20240711_9781837694334_135 |