Molecular Characterization of Gram-Negative Bacteria: Antimicrobial Resistance, Virulence and Epidemiology
Multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) Gram-negative bacteria constitute a huge public health problem. Among them, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii are the main bacteria contributing to increased rates of an...
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| Định dạng: | Online |
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| Ngôn ngữ: | Tiếng Anh |
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MDPI - Multidisciplinary Digital Publishing Institute
2024
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| Truy cập trực tuyến: | ONIX_20240906_9783725814183_108 |
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| collection | Directory of Open Access Books |
| description | Multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) Gram-negative bacteria constitute a huge public health problem. Among them, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii are the main bacteria contributing to increased rates of antimicrobial resistance. Infections caused by these bacteria can have a negative impact on the financial costs and outcomes of patient hospitalization. The increased consumption of antimicrobials and the poor implementation of infection control measures in the hospital setting are the two main causative factors for their emergence. Deep knowledge of the virulent factors that these bacteria produce could provide useful information regarding their spread. The main problem concerning infections caused by these bacteria is that treatment options are extremely limited, as there has been a poor launch of novel antimicrobials over the last few years. The molecular epidemiology of infections caused by Gram-negative bacteria is significant as it can determine which of these few new antimicrobial agents could be effective for their treatment. This Special Issue collects manuscript submissions that expand our knowledge of antimicrobial resistance in Gram-negative bacteria. |
| format | Online |
| id | doab-20.500.12854ir-143746 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1437462024-09-06T08:17:04Z Molecular Characterization of Gram-Negative Bacteria: Antimicrobial Resistance, Virulence and Epidemiology Karampatakis, Theodoros Klebsiella pneumoniae multidrug-resistant extensively drug-resistant colistin carbapenem quantitative proteomics tandem mass tag Acinetobacter baumannii secretion systems pathogenicity antibiotic resistance multidrug resistance transmission Sudan carbapenem-resistant Klebsiella pneumoniae molecular epidemiology antimicrobial agents virulence factors phloroglucinol polyketide DAPG phlD Ramachandran plot PMDB duck–fish polyculture farm Escherichia coli blaCTX-M-55 F18:A-:B1 whole genome sequencing core genome single-nucleotide polymorphism analysis antimicrobial resistance antibiotics synergy carbapenemase NDM-beta-lactamase carbapenemases NDM plasmid Proteus mirabilis Morganella morganii carbapenem-resistant Acinetobacter baumannii cefiderocol sulbactam-durlobactam antimicrobial susceptibility mechanisms of resistance antimicrobial therapy oxygen concentration biofilm pyocyanin pyoverdine motility proteases colistin resistance mechanisms mgrB population analysis profiling whole-genome sequencing n/a thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) Gram-negative bacteria constitute a huge public health problem. Among them, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii are the main bacteria contributing to increased rates of antimicrobial resistance. Infections caused by these bacteria can have a negative impact on the financial costs and outcomes of patient hospitalization. The increased consumption of antimicrobials and the poor implementation of infection control measures in the hospital setting are the two main causative factors for their emergence. Deep knowledge of the virulent factors that these bacteria produce could provide useful information regarding their spread. The main problem concerning infections caused by these bacteria is that treatment options are extremely limited, as there has been a poor launch of novel antimicrobials over the last few years. The molecular epidemiology of infections caused by Gram-negative bacteria is significant as it can determine which of these few new antimicrobial agents could be effective for their treatment. This Special Issue collects manuscript submissions that expand our knowledge of antimicrobial resistance in Gram-negative bacteria. 2024-09-06T08:16:59Z 2024-09-06T08:16:59Z 2024 book ONIX_20240906_9783725814183_108 9783725814183 9783725814176 https://directory.doabooks.org/handle/20.500.12854/143746 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/9467 https://mdpi.com/books/pdfview/book/9467 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-1417-6 10.3390/books978-3-7258-1417-6 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725814183 9783725814176 open access |
| spellingShingle | Klebsiella pneumoniae multidrug-resistant extensively drug-resistant colistin carbapenem quantitative proteomics tandem mass tag Acinetobacter baumannii secretion systems pathogenicity antibiotic resistance multidrug resistance transmission Sudan carbapenem-resistant Klebsiella pneumoniae molecular epidemiology antimicrobial agents virulence factors phloroglucinol polyketide DAPG phlD Ramachandran plot PMDB duck–fish polyculture farm Escherichia coli blaCTX-M-55 F18:A-:B1 whole genome sequencing core genome single-nucleotide polymorphism analysis antimicrobial resistance antibiotics synergy carbapenemase NDM-beta-lactamase carbapenemases NDM plasmid Proteus mirabilis Morganella morganii carbapenem-resistant Acinetobacter baumannii cefiderocol sulbactam-durlobactam antimicrobial susceptibility mechanisms of resistance antimicrobial therapy oxygen concentration biofilm pyocyanin pyoverdine motility proteases colistin resistance mechanisms mgrB population analysis profiling whole-genome sequencing n/a thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Molecular Characterization of Gram-Negative Bacteria: Antimicrobial Resistance, Virulence and Epidemiology |
| title | Molecular Characterization of Gram-Negative Bacteria: Antimicrobial Resistance, Virulence and Epidemiology |
| title_full | Molecular Characterization of Gram-Negative Bacteria: Antimicrobial Resistance, Virulence and Epidemiology |
| title_fullStr | Molecular Characterization of Gram-Negative Bacteria: Antimicrobial Resistance, Virulence and Epidemiology |
| title_full_unstemmed | Molecular Characterization of Gram-Negative Bacteria: Antimicrobial Resistance, Virulence and Epidemiology |
| title_short | Molecular Characterization of Gram-Negative Bacteria: Antimicrobial Resistance, Virulence and Epidemiology |
| title_sort | molecular characterization of gram negative bacteria antimicrobial resistance virulence and epidemiology |
| topic | Klebsiella pneumoniae multidrug-resistant extensively drug-resistant colistin carbapenem quantitative proteomics tandem mass tag Acinetobacter baumannii secretion systems pathogenicity antibiotic resistance multidrug resistance transmission Sudan carbapenem-resistant Klebsiella pneumoniae molecular epidemiology antimicrobial agents virulence factors phloroglucinol polyketide DAPG phlD Ramachandran plot PMDB duck–fish polyculture farm Escherichia coli blaCTX-M-55 F18:A-:B1 whole genome sequencing core genome single-nucleotide polymorphism analysis antimicrobial resistance antibiotics synergy carbapenemase NDM-beta-lactamase carbapenemases NDM plasmid Proteus mirabilis Morganella morganii carbapenem-resistant Acinetobacter baumannii cefiderocol sulbactam-durlobactam antimicrobial susceptibility mechanisms of resistance antimicrobial therapy oxygen concentration biofilm pyocyanin pyoverdine motility proteases colistin resistance mechanisms mgrB population analysis profiling whole-genome sequencing n/a thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | Klebsiella pneumoniae multidrug-resistant extensively drug-resistant colistin carbapenem quantitative proteomics tandem mass tag Acinetobacter baumannii secretion systems pathogenicity antibiotic resistance multidrug resistance transmission Sudan carbapenem-resistant Klebsiella pneumoniae molecular epidemiology antimicrobial agents virulence factors phloroglucinol polyketide DAPG phlD Ramachandran plot PMDB duck–fish polyculture farm Escherichia coli blaCTX-M-55 F18:A-:B1 whole genome sequencing core genome single-nucleotide polymorphism analysis antimicrobial resistance antibiotics synergy carbapenemase NDM-beta-lactamase carbapenemases NDM plasmid Proteus mirabilis Morganella morganii carbapenem-resistant Acinetobacter baumannii cefiderocol sulbactam-durlobactam antimicrobial susceptibility mechanisms of resistance antimicrobial therapy oxygen concentration biofilm pyocyanin pyoverdine motility proteases colistin resistance mechanisms mgrB population analysis profiling whole-genome sequencing n/a thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20240906_9783725814183_108 |