Role of NO in Disease: Good, Bad or Ugly
This Special Issue of Biomedicines, “Role of NO in Disease: Good, Bad or Ugly”, focuses on the roles of nitric oxide (NO) in disease from various aspects. NO plays an important role in several physiological processes with numerous biological targets, such as cardiovascular homeostasis, angiogenesis,...
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| Ձևաչափ: | Online |
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MDPI - Multidisciplinary Digital Publishing Institute
2024
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| Առցանց հասանելիություն: | ONIX_20240906_9783725815630_181 |
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| description | This Special Issue of Biomedicines, “Role of NO in Disease: Good, Bad or Ugly”, focuses on the roles of nitric oxide (NO) in disease from various aspects. NO plays an important role in several physiological processes with numerous biological targets, such as cardiovascular homeostasis, angiogenesis, neural signaling, inflammatory processes, and immune regulation. Hence, it is obvious that essentially all cells and biological activities are modulated by NO. This reactive and toxic two-atom gaseous molecule has an unpaired electron and is therefore considered a free radical. It is one of the most important signaling molecules. NO was most likely generated by volcanic emissions in the early atmosphere, from CO2 and N2, approximately 4.5 billion years ago, long before the appearance of the living organisms that now contribute significantly to the cycling of nitrogen species. Endogenous NO is catalyzed from L-arginine by mammalian nitric oxide synthases (NOS). However, NOS-like enzymes have also been found in procaryotes, bacteria, and eukaryotes, suggesting a basic role of NO in the evolutionary process. Thus, it is not surprising that NO signaling is spread throughout the entire phylogenetic scale. |
| format | Online |
| id | doab-20.500.12854ir-143819 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
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| spelling | doab-20.500.12854ir-1438192024-09-06T08:32:09Z Role of NO in Disease: Good, Bad or Ugly Eriksson, Mats B. Larsson, Anders O. nitric oxide COVID-19 acute respiratory syndrome coronavirus 2 inhaled nitric oxide therapy endothelium vascular function obesity adiponectin SIRT1 sensors macrophages atherosclerosis UVA nitrite cold atmospheric plasma nitric oxide donor skin wound healing microcirculation COPD fraction exhaled nitric oxide and lung function tests comorbidity GOLD mathematical model gas exchange disease chronic granulomatous disease bladder cancer furoxans nitric oxide donors NF-κB survivin renin hypoxia HIFs juxtaglomerular cells rheumatoid arthritis free secretory component ACPA exhaled nitric oxide lung pathogenesis rheumatoid factor breastfeeding human milk nitrate saliva n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology This Special Issue of Biomedicines, “Role of NO in Disease: Good, Bad or Ugly”, focuses on the roles of nitric oxide (NO) in disease from various aspects. NO plays an important role in several physiological processes with numerous biological targets, such as cardiovascular homeostasis, angiogenesis, neural signaling, inflammatory processes, and immune regulation. Hence, it is obvious that essentially all cells and biological activities are modulated by NO. This reactive and toxic two-atom gaseous molecule has an unpaired electron and is therefore considered a free radical. It is one of the most important signaling molecules. NO was most likely generated by volcanic emissions in the early atmosphere, from CO2 and N2, approximately 4.5 billion years ago, long before the appearance of the living organisms that now contribute significantly to the cycling of nitrogen species. Endogenous NO is catalyzed from L-arginine by mammalian nitric oxide synthases (NOS). However, NOS-like enzymes have also been found in procaryotes, bacteria, and eukaryotes, suggesting a basic role of NO in the evolutionary process. Thus, it is not surprising that NO signaling is spread throughout the entire phylogenetic scale. 2024-09-06T08:32:02Z 2024-09-06T08:32:02Z 2024 book ONIX_20240906_9783725815630_181 9783725815630 9783725815647 https://directory.doabooks.org/handle/20.500.12854/143819 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/9569 https://mdpi.com/books/pdfview/book/9569 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-1564-7 10.3390/books978-3-7258-1564-7 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725815630 9783725815647 open access |
| spellingShingle | nitric oxide COVID-19 acute respiratory syndrome coronavirus 2 inhaled nitric oxide therapy endothelium vascular function obesity adiponectin SIRT1 sensors macrophages atherosclerosis UVA nitrite cold atmospheric plasma nitric oxide donor skin wound healing microcirculation COPD fraction exhaled nitric oxide and lung function tests comorbidity GOLD mathematical model gas exchange disease chronic granulomatous disease bladder cancer furoxans nitric oxide donors NF-κB survivin renin hypoxia HIFs juxtaglomerular cells rheumatoid arthritis free secretory component ACPA exhaled nitric oxide lung pathogenesis rheumatoid factor breastfeeding human milk nitrate saliva n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Role of NO in Disease: Good, Bad or Ugly |
| title | Role of NO in Disease: Good, Bad or Ugly |
| title_full | Role of NO in Disease: Good, Bad or Ugly |
| title_fullStr | Role of NO in Disease: Good, Bad or Ugly |
| title_full_unstemmed | Role of NO in Disease: Good, Bad or Ugly |
| title_short | Role of NO in Disease: Good, Bad or Ugly |
| title_sort | role of no in disease good bad or ugly |
| topic | nitric oxide COVID-19 acute respiratory syndrome coronavirus 2 inhaled nitric oxide therapy endothelium vascular function obesity adiponectin SIRT1 sensors macrophages atherosclerosis UVA nitrite cold atmospheric plasma nitric oxide donor skin wound healing microcirculation COPD fraction exhaled nitric oxide and lung function tests comorbidity GOLD mathematical model gas exchange disease chronic granulomatous disease bladder cancer furoxans nitric oxide donors NF-κB survivin renin hypoxia HIFs juxtaglomerular cells rheumatoid arthritis free secretory component ACPA exhaled nitric oxide lung pathogenesis rheumatoid factor breastfeeding human milk nitrate saliva n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| topic_facet | nitric oxide COVID-19 acute respiratory syndrome coronavirus 2 inhaled nitric oxide therapy endothelium vascular function obesity adiponectin SIRT1 sensors macrophages atherosclerosis UVA nitrite cold atmospheric plasma nitric oxide donor skin wound healing microcirculation COPD fraction exhaled nitric oxide and lung function tests comorbidity GOLD mathematical model gas exchange disease chronic granulomatous disease bladder cancer furoxans nitric oxide donors NF-κB survivin renin hypoxia HIFs juxtaglomerular cells rheumatoid arthritis free secretory component ACPA exhaled nitric oxide lung pathogenesis rheumatoid factor breastfeeding human milk nitrate saliva n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| url | ONIX_20240906_9783725815630_181 |