Oxidative Stress in Brain Function
The different cellular mechanisms that govern complex brain functions are regulated through intrinsic (genetic) or external (environmental) factors. One of the most critical regulatory axes at the cellular level is established around the cellular capacities that counteract the oxidative stress emerg...
I tiakina i:
| Hōputu: | Online |
|---|---|
| Reo: | Ingarihi |
| I whakaputaina: |
MDPI - Multidisciplinary Digital Publishing Institute
2024
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| Ngā marau: | |
| Urunga tuihono: | ONIX_20240906_9783725811496_187 |
| Ngā Tūtohu: |
Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!
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| _version_ | 1869521200598745088 |
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| collection | Directory of Open Access Books |
| description | The different cellular mechanisms that govern complex brain functions are regulated through intrinsic (genetic) or external (environmental) factors. One of the most critical regulatory axes at the cellular level is established around the cellular capacities that counteract the oxidative stress emerging in different pathophysiological contexts. At the brain level, this control is essential due to the limited capacity of neurons in forming new cells. Therefore, brain cells cope very efficiently with oxidative stress, and their functions are only altered when these cellular strategies are overwhelmed. This reprint contains original research and review articles on the regulation of cellular processes where antioxidant defenses are essential for maintaining the normal functioning of brain cells, including different cellular signaling mechanisms and their dysfunction. |
| format | Online |
| id | doab-20.500.12854ir-143825 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1438252024-09-06T08:33:25Z Oxidative Stress in Brain Function Cerpa, Waldo traumatic brain injury mitochondrial calcium NCLX hippocampus allopregnanolone microglia neuroinflammation neurosteroids reactive oxygen species rotenone 3CAI astrocyte autophagy GPx1 NAC oxidative stress seizure TMCB electroencephalography sleep antioxidants schizophrenia N-acetylcysteine sleep deprivation stress glutathione GSH GSSG catalase CAT superoxide dismutase SOD nitric oxide NOx lipid peroxidation MDA rat endoplasmic reticulum stress mitochondria unfolded protein response neurodegeneration proteostasis calcium brain nitrosative stress oxygen homeostasis inflammation and immunity NLRP3 inflammasome Nrf2 NOX4 glial cultures KO mice neurodegenerative diseases c-Abl mitofusin 2 apoptosis mitochondrial fusion amyotrophic lateral sclerosis heavy metals kynurenic acid cognition mitochondria free radicals cell death therapeutics neuroprotection amlodipine L-type voltage-gated calcium channel zinc neuronal death thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology The different cellular mechanisms that govern complex brain functions are regulated through intrinsic (genetic) or external (environmental) factors. One of the most critical regulatory axes at the cellular level is established around the cellular capacities that counteract the oxidative stress emerging in different pathophysiological contexts. At the brain level, this control is essential due to the limited capacity of neurons in forming new cells. Therefore, brain cells cope very efficiently with oxidative stress, and their functions are only altered when these cellular strategies are overwhelmed. This reprint contains original research and review articles on the regulation of cellular processes where antioxidant defenses are essential for maintaining the normal functioning of brain cells, including different cellular signaling mechanisms and their dysfunction. 2024-09-06T08:33:17Z 2024-09-06T08:33:17Z 2024 book ONIX_20240906_9783725811496_187 9783725811496 9783725811502 https://directory.doabooks.org/handle/20.500.12854/143825 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/9577 https://mdpi.com/books/pdfview/book/9577 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-1150-2 10.3390/books978-3-7258-1150-2 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725811496 9783725811502 open access |
| spellingShingle | traumatic brain injury mitochondrial calcium NCLX hippocampus allopregnanolone microglia neuroinflammation neurosteroids reactive oxygen species rotenone 3CAI astrocyte autophagy GPx1 NAC oxidative stress seizure TMCB electroencephalography sleep antioxidants schizophrenia N-acetylcysteine sleep deprivation stress glutathione GSH GSSG catalase CAT superoxide dismutase SOD nitric oxide NOx lipid peroxidation MDA rat endoplasmic reticulum stress mitochondria unfolded protein response neurodegeneration proteostasis calcium brain nitrosative stress oxygen homeostasis inflammation and immunity NLRP3 inflammasome Nrf2 NOX4 glial cultures KO mice neurodegenerative diseases c-Abl mitofusin 2 apoptosis mitochondrial fusion amyotrophic lateral sclerosis heavy metals kynurenic acid cognition mitochondria free radicals cell death therapeutics neuroprotection amlodipine L-type voltage-gated calcium channel zinc neuronal death thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology Oxidative Stress in Brain Function |
| title | Oxidative Stress in Brain Function |
| title_full | Oxidative Stress in Brain Function |
| title_fullStr | Oxidative Stress in Brain Function |
| title_full_unstemmed | Oxidative Stress in Brain Function |
| title_short | Oxidative Stress in Brain Function |
| title_sort | oxidative stress in brain function |
| topic | traumatic brain injury mitochondrial calcium NCLX hippocampus allopregnanolone microglia neuroinflammation neurosteroids reactive oxygen species rotenone 3CAI astrocyte autophagy GPx1 NAC oxidative stress seizure TMCB electroencephalography sleep antioxidants schizophrenia N-acetylcysteine sleep deprivation stress glutathione GSH GSSG catalase CAT superoxide dismutase SOD nitric oxide NOx lipid peroxidation MDA rat endoplasmic reticulum stress mitochondria unfolded protein response neurodegeneration proteostasis calcium brain nitrosative stress oxygen homeostasis inflammation and immunity NLRP3 inflammasome Nrf2 NOX4 glial cultures KO mice neurodegenerative diseases c-Abl mitofusin 2 apoptosis mitochondrial fusion amyotrophic lateral sclerosis heavy metals kynurenic acid cognition mitochondria free radicals cell death therapeutics neuroprotection amlodipine L-type voltage-gated calcium channel zinc neuronal death thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology |
| topic_facet | traumatic brain injury mitochondrial calcium NCLX hippocampus allopregnanolone microglia neuroinflammation neurosteroids reactive oxygen species rotenone 3CAI astrocyte autophagy GPx1 NAC oxidative stress seizure TMCB electroencephalography sleep antioxidants schizophrenia N-acetylcysteine sleep deprivation stress glutathione GSH GSSG catalase CAT superoxide dismutase SOD nitric oxide NOx lipid peroxidation MDA rat endoplasmic reticulum stress mitochondria unfolded protein response neurodegeneration proteostasis calcium brain nitrosative stress oxygen homeostasis inflammation and immunity NLRP3 inflammasome Nrf2 NOX4 glial cultures KO mice neurodegenerative diseases c-Abl mitofusin 2 apoptosis mitochondrial fusion amyotrophic lateral sclerosis heavy metals kynurenic acid cognition mitochondria free radicals cell death therapeutics neuroprotection amlodipine L-type voltage-gated calcium channel zinc neuronal death thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology |
| url | ONIX_20240906_9783725811496_187 |