Rare Neurodegenerative Disorders
Neurodegenerative diseases share the common property of neuronal loss in the higher-order association and limbic cortices or the extrapyramidal and pyramidal motor systems. In addition, oligodendroglia, astrocytes, and microglia have been implicated in fundamental abnormalities of virtually every ne...
Αποθηκεύτηκε σε:
| Μορφή: | Online |
|---|---|
| Γλώσσα: | Αγγλικά |
| Έκδοση: |
IntechOpen
2024
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| Θέματα: | |
| Διαθέσιμο Online: | ONIX_20241025_9780850148046_25 |
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| _version_ | 1869520712301019136 |
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| collection | Directory of Open Access Books |
| description | Neurodegenerative diseases share the common property of neuronal loss in the higher-order association and limbic cortices or the extrapyramidal and pyramidal motor systems. In addition, oligodendroglia, astrocytes, and microglia have been implicated in fundamental abnormalities of virtually every neurodegenerative disorder. The particular system affected, more importantly the distribution of the pathology, determines the clinical presentation. While the most common dementia and movement disorders, such as Alzheimer’s disease, Lewy body disease, and frontotemporal lobar degeneration with TDP-43 pathology, including amyotrophic lateral sclerosis, have been extensively studied, many less common, even rare neurodegenerative disorders have gained more attention in recent years. This shift in focus is perhaps driven, in part, by the severely underestimated financial costs associated with these diseases, as well as the immense emotional burden they impose on patients and their caregivers. This book presents the most recent developments in rare neurodegenerative disorders. Insights gained from the investigation of pathophysiological mechanisms of these rare disorders may lead to the development of therapeutic strategies for more prevalent neurodegenerative disorders. In addition to highlighting advancements in research, the book discusses the significant challenges faced by researchers and healthcare professionals in diagnosing and treating rare diseases. It emphasizes the critical need for continued funding and support for research, which is essential to improving patient outcomes and advancing our understanding of these complex conditions. |
| format | Online |
| id | doab-20.500.12854ir-146482 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1464822024-10-25T10:44:24Z Rare Neurodegenerative Disorders Chen, Liam Neurology and clinical neurophysiology thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology Neurodegenerative diseases share the common property of neuronal loss in the higher-order association and limbic cortices or the extrapyramidal and pyramidal motor systems. In addition, oligodendroglia, astrocytes, and microglia have been implicated in fundamental abnormalities of virtually every neurodegenerative disorder. The particular system affected, more importantly the distribution of the pathology, determines the clinical presentation. While the most common dementia and movement disorders, such as Alzheimer’s disease, Lewy body disease, and frontotemporal lobar degeneration with TDP-43 pathology, including amyotrophic lateral sclerosis, have been extensively studied, many less common, even rare neurodegenerative disorders have gained more attention in recent years. This shift in focus is perhaps driven, in part, by the severely underestimated financial costs associated with these diseases, as well as the immense emotional burden they impose on patients and their caregivers. This book presents the most recent developments in rare neurodegenerative disorders. Insights gained from the investigation of pathophysiological mechanisms of these rare disorders may lead to the development of therapeutic strategies for more prevalent neurodegenerative disorders. In addition to highlighting advancements in research, the book discusses the significant challenges faced by researchers and healthcare professionals in diagnosing and treating rare diseases. It emphasizes the critical need for continued funding and support for research, which is essential to improving patient outcomes and advancing our understanding of these complex conditions. 2024-10-25T10:44:22Z 2024-10-25T10:44:22Z 2024 book ONIX_20241025_9780850148046_25 9780850148046 9780850148053 9780850148060 https://directory.doabooks.org/handle/20.500.12854/146482 eng image/jpeg n/a https://www.intechopen.com/books/13596 https://intech-files.s3.amazonaws.com/a043Y0000114WIuQAM/0015630_Authors_Book%20%282024-10-03%2010%3A09%3A59%29.pdf IntechOpen IntechOpen 10.5772/intechopen.112607 10.5772/intechopen.112607 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9780850148046 9780850148053 9780850148060 IntechOpen 198 open access |
| spellingShingle | Neurology and clinical neurophysiology thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology Rare Neurodegenerative Disorders |
| title | Rare Neurodegenerative Disorders |
| title_full | Rare Neurodegenerative Disorders |
| title_fullStr | Rare Neurodegenerative Disorders |
| title_full_unstemmed | Rare Neurodegenerative Disorders |
| title_short | Rare Neurodegenerative Disorders |
| title_sort | rare neurodegenerative disorders |
| topic | Neurology and clinical neurophysiology thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology |
| topic_facet | Neurology and clinical neurophysiology thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology |
| url | ONIX_20241025_9780850148046_25 |