Free-Radical Scavenging and Antioxidant Properties of Melatonin
Melatonin is an indoleamine that has captured our attention since 1958. It was discovered as one of the main regulators of circadian rhythms. At that time, it was simply defined as the sleep–wake regulator hormone, as melatonin is mainly secreted by the pineal gland during the night. Its role in sea...
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| Materialtyp: | Online |
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| Språk: | engelska |
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MDPI - Multidisciplinary Digital Publishing Institute
2025
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| Länkar: | ONIX_20250220_9783725821488_136 |
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| description | Melatonin is an indoleamine that has captured our attention since 1958. It was discovered as one of the main regulators of circadian rhythms. At that time, it was simply defined as the sleep–wake regulator hormone, as melatonin is mainly secreted by the pineal gland during the night. Its role in seasonal reproductive functions was also found very soon after. Later, the extra-pineal synthesis of melatonin was discovered (immune system, retina, etc.), together with its production in other organisms, such as bacteria and plants. This fact changed the idea that melatonin was just a hormone that synchronized processes related with the circadian and seasonal rhythms and brought up the role of melatonin as a very potent antioxidant. With this Special Issue, we aim to explore the most recent roles of melatonin as an antioxidant, and we provide a great deal of new information: from melatonin synthesis in a new domain to recent uses of melatonin as a therapy and synergistic treatment for cancer. Thus, we are sure that this indoleamine will be in the spotlight for much more time to come. |
| format | Online |
| id | doab-20.500.12854ir-152772 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1527722025-02-20T13:02:43Z Free-Radical Scavenging and Antioxidant Properties of Melatonin Garcia-Macia, Marina Santos-Ledo, Adrián archaea Ard1 N-acetylserotonin N-acetyltyramine synthetic genes melatonin rice seed size monochromatic light combination oxidative stress nuclear receptor B lymphocyte apoptosis chick reactive oxygen species mitochondria cancer dose-response BAT thermogenesis UCP1 obesity ZDF rat metallodrugs platinum(II) complex thiazoline breast cancer sulfur and nitrogen mustard melatonin metabolites NLRP3 inflammasome DNA damage agomelatine p53 circadian clock colorectal cancer SIRT1 sepsis-associated encephalopathy sepsis antioxidant neuroinflammation neurodevelopmental disorders brain development circadian rhythms sleep–wake rhythms sleep disturbance autism schizophrenia regeneration ROS zebrafish visual system n/a thema EDItEUR::A The Arts::AT Performing arts::ATD Theatre studies Melatonin is an indoleamine that has captured our attention since 1958. It was discovered as one of the main regulators of circadian rhythms. At that time, it was simply defined as the sleep–wake regulator hormone, as melatonin is mainly secreted by the pineal gland during the night. Its role in seasonal reproductive functions was also found very soon after. Later, the extra-pineal synthesis of melatonin was discovered (immune system, retina, etc.), together with its production in other organisms, such as bacteria and plants. This fact changed the idea that melatonin was just a hormone that synchronized processes related with the circadian and seasonal rhythms and brought up the role of melatonin as a very potent antioxidant. With this Special Issue, we aim to explore the most recent roles of melatonin as an antioxidant, and we provide a great deal of new information: from melatonin synthesis in a new domain to recent uses of melatonin as a therapy and synergistic treatment for cancer. Thus, we are sure that this indoleamine will be in the spotlight for much more time to come. 2025-02-20T13:02:41Z 2025-02-20T13:02:41Z 2024 book ONIX_20250220_9783725821488_136 9783725821488 9783725821471 https://directory.doabooks.org/handle/20.500.12854/152772 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/9940 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-2147-1 10.3390/books978-3-7258-2147-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725821488 9783725821471 188 Basel open access |
| spellingShingle | archaea Ard1 N-acetylserotonin N-acetyltyramine synthetic genes melatonin rice seed size monochromatic light combination oxidative stress nuclear receptor B lymphocyte apoptosis chick reactive oxygen species mitochondria cancer dose-response BAT thermogenesis UCP1 obesity ZDF rat metallodrugs platinum(II) complex thiazoline breast cancer sulfur and nitrogen mustard melatonin metabolites NLRP3 inflammasome DNA damage agomelatine p53 circadian clock colorectal cancer SIRT1 sepsis-associated encephalopathy sepsis antioxidant neuroinflammation neurodevelopmental disorders brain development circadian rhythms sleep–wake rhythms sleep disturbance autism schizophrenia regeneration ROS zebrafish visual system n/a thema EDItEUR::A The Arts::AT Performing arts::ATD Theatre studies Free-Radical Scavenging and Antioxidant Properties of Melatonin |
| title | Free-Radical Scavenging and Antioxidant Properties of Melatonin |
| title_full | Free-Radical Scavenging and Antioxidant Properties of Melatonin |
| title_fullStr | Free-Radical Scavenging and Antioxidant Properties of Melatonin |
| title_full_unstemmed | Free-Radical Scavenging and Antioxidant Properties of Melatonin |
| title_short | Free-Radical Scavenging and Antioxidant Properties of Melatonin |
| title_sort | free radical scavenging and antioxidant properties of melatonin |
| topic | archaea Ard1 N-acetylserotonin N-acetyltyramine synthetic genes melatonin rice seed size monochromatic light combination oxidative stress nuclear receptor B lymphocyte apoptosis chick reactive oxygen species mitochondria cancer dose-response BAT thermogenesis UCP1 obesity ZDF rat metallodrugs platinum(II) complex thiazoline breast cancer sulfur and nitrogen mustard melatonin metabolites NLRP3 inflammasome DNA damage agomelatine p53 circadian clock colorectal cancer SIRT1 sepsis-associated encephalopathy sepsis antioxidant neuroinflammation neurodevelopmental disorders brain development circadian rhythms sleep–wake rhythms sleep disturbance autism schizophrenia regeneration ROS zebrafish visual system n/a thema EDItEUR::A The Arts::AT Performing arts::ATD Theatre studies |
| topic_facet | archaea Ard1 N-acetylserotonin N-acetyltyramine synthetic genes melatonin rice seed size monochromatic light combination oxidative stress nuclear receptor B lymphocyte apoptosis chick reactive oxygen species mitochondria cancer dose-response BAT thermogenesis UCP1 obesity ZDF rat metallodrugs platinum(II) complex thiazoline breast cancer sulfur and nitrogen mustard melatonin metabolites NLRP3 inflammasome DNA damage agomelatine p53 circadian clock colorectal cancer SIRT1 sepsis-associated encephalopathy sepsis antioxidant neuroinflammation neurodevelopmental disorders brain development circadian rhythms sleep–wake rhythms sleep disturbance autism schizophrenia regeneration ROS zebrafish visual system n/a thema EDItEUR::A The Arts::AT Performing arts::ATD Theatre studies |
| url | ONIX_20250220_9783725821488_136 |