Feature Paper in Physiology and Pathology
Dear Colleagues, this Special Issue aims to explore the role of natural molecules in pharmacology and biotechnology, highlighting their potential as bioactive compounds and therapeutic agents. Focusing on drug discovery, molecular biology, and the development of new treatments, this reprint presents...
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| Формат: | Online |
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| Язык: | английский |
| Опубликовано: |
MDPI - Multidisciplinary Digital Publishing Institute
2025
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| Предметы: | |
| Online-ссылка: | ONIX_20250220_9783725821761_150 |
| Метки: |
Нет меток, Требуется 1-ая метка записи!
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| _version_ | 1869515037683482624 |
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| collection | Directory of Open Access Books |
| description | Dear Colleagues, this Special Issue aims to explore the role of natural molecules in pharmacology and biotechnology, highlighting their potential as bioactive compounds and therapeutic agents. Focusing on drug discovery, molecular biology, and the development of new treatments, this reprint presents cutting-edge research on the application of natural products in various medical fields. The collected works provide valuable insights for researchers and practitioners interested in exploring how these molecules can be harnessed for innovative therapeutic strategies. |
| format | Online |
| id | doab-20.500.12854ir-152786 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1527862025-02-20T13:04:01Z Feature Paper in Physiology and Pathology Roumeliotis, Stefanos Minervini, Giuseppe kidney fibrosis chronic kidney disease TGFβR-1 flavonoids pharmacokinetics molecular docking molecular dynamics simulations retrospective cohort study kidney disease end-stage kidney disease vitamin D tuberculosis type 2 diabetes mellitus genetic susceptibility molecular chaperons heat shock factor 1 (HSF1) single nucleotide polymorphism gene expression protein folding unfolded protein response body mass index obesity sex dimorphism NF-κB signaling signaling dynamics cell-fate decision encoding and decoding cellular information human diseases prolyl hydroxylase domain-containing protein PHD protein Phd1 gene osteoblast chondrocyte knockout mice phenotype hypoxia-inducible factor endochondral bone formation MRI prefrontal areas putamen gray matter volume specific phobia cognition rice intake adults Qatar Biobank study Neoplasia exercise sensitivity chemotherapy measurement of results reported by the patient biomechanics osteoarthritis cartilage musculoskeletal simulation probabilistic modelling experimental autoimmune encephalomyelitis colitis growth factors nematode adaptation angiogenesis knee joint biomarkers extracellular vesicles sepsis coagulation disseminated intravascular coagulation sepsis-induced coagulopathy laboratory evaluation guidelines cell competition cellular Potts model invasion travelling wave neutrophil extracellular traps peripheral blood infection digital white blood cell differential genetic disease prevalence penetrance accurate diagnosis disease iceberg effect cumulative lifetime risk familial aggregation ozone ozone therapy oxidative stress antioxidants defense inflammation dupilumab biologic dermatitis lichen amyloidosis primary cutaneous amyloidosis primary localized cutaneous amyloidosis IgG4-related disease IgG4-related skin disease immunoglobulin G4-related disease immunoglobulin G4-related skin disease WNT16 chondrocytes mice chondrogenesis cell culture subarachnoid hemorrhage bone-marrow mesenchymal stem cells cognitive impairment high-mobility group box 1 central centrifugal cicatricial alopecia scarring alopecia pediatric scarring hair loss skin of colour public health ambulatory blood pressure antihypertensive therapy peritoneal dialysis sex differences geranylgeraniol GGOH bisphosphonates medication-related osteonecrosis of the jaw MRONJ mevalonate pathway platelets PEVs hemostasis wound healing carcinogenesis therapy imidacloprid apoptosis telencephalon zebrafish serous endometrial intraepithelial carcinoma SEIC MUSC adjuvant therapy relapse BK-polyomavirus decoy cell polyoma nephropathy large T antigen VP1 complications congenital heart disease ECMO extracorporeal life support mortality risk factors single ventricle BOLD signal variability pediatrics biomarker fMRI neurodevelopment grip strength young children active play growth and development platelet-rich plasma rhein knee osteoarthritis Crohn’s disease intestinal ultrasonography contrast-enhanced ultrasound MR enterography depressive disorders cognitive function physical function dementia older people copepods lipidomics climate change oceanic food chain sentinel species patient blood management red blood cell transfusion hemoglobin retrospective study social isolation space radiation blood–brain barrier lateral ventricle n/a post-stroke depression behavioral tests social activity motor function antidepressants murine models of depression thema EDItEUR::A The Arts::AT Performing arts::ATD Theatre studies thema EDItEUR::A The Arts::AV Music Dear Colleagues, this Special Issue aims to explore the role of natural molecules in pharmacology and biotechnology, highlighting their potential as bioactive compounds and therapeutic agents. Focusing on drug discovery, molecular biology, and the development of new treatments, this reprint presents cutting-edge research on the application of natural products in various medical fields. The collected works provide valuable insights for researchers and practitioners interested in exploring how these molecules can be harnessed for innovative therapeutic strategies. 2025-02-20T13:03:59Z 2025-02-20T13:03:59Z 2024 book ONIX_20250220_9783725821761_150 9783725821761 9783725821754 https://directory.doabooks.org/handle/20.500.12854/152786 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/10019 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-2175-4 10.3390/books978-3-7258-2175-4 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725821761 9783725821754 558 Basel open access |
| spellingShingle | kidney fibrosis chronic kidney disease TGFβR-1 flavonoids pharmacokinetics molecular docking molecular dynamics simulations retrospective cohort study kidney disease end-stage kidney disease vitamin D tuberculosis type 2 diabetes mellitus genetic susceptibility molecular chaperons heat shock factor 1 (HSF1) single nucleotide polymorphism gene expression protein folding unfolded protein response body mass index obesity sex dimorphism NF-κB signaling signaling dynamics cell-fate decision encoding and decoding cellular information human diseases prolyl hydroxylase domain-containing protein PHD protein Phd1 gene osteoblast chondrocyte knockout mice phenotype hypoxia-inducible factor endochondral bone formation MRI prefrontal areas putamen gray matter volume specific phobia cognition rice intake adults Qatar Biobank study Neoplasia exercise sensitivity chemotherapy measurement of results reported by the patient biomechanics osteoarthritis cartilage musculoskeletal simulation probabilistic modelling experimental autoimmune encephalomyelitis colitis growth factors nematode adaptation angiogenesis knee joint biomarkers extracellular vesicles sepsis coagulation disseminated intravascular coagulation sepsis-induced coagulopathy laboratory evaluation guidelines cell competition cellular Potts model invasion travelling wave neutrophil extracellular traps peripheral blood infection digital white blood cell differential genetic disease prevalence penetrance accurate diagnosis disease iceberg effect cumulative lifetime risk familial aggregation ozone ozone therapy oxidative stress antioxidants defense inflammation dupilumab biologic dermatitis lichen amyloidosis primary cutaneous amyloidosis primary localized cutaneous amyloidosis IgG4-related disease IgG4-related skin disease immunoglobulin G4-related disease immunoglobulin G4-related skin disease WNT16 chondrocytes mice chondrogenesis cell culture subarachnoid hemorrhage bone-marrow mesenchymal stem cells cognitive impairment high-mobility group box 1 central centrifugal cicatricial alopecia scarring alopecia pediatric scarring hair loss skin of colour public health ambulatory blood pressure antihypertensive therapy peritoneal dialysis sex differences geranylgeraniol GGOH bisphosphonates medication-related osteonecrosis of the jaw MRONJ mevalonate pathway platelets PEVs hemostasis wound healing carcinogenesis therapy imidacloprid apoptosis telencephalon zebrafish serous endometrial intraepithelial carcinoma SEIC MUSC adjuvant therapy relapse BK-polyomavirus decoy cell polyoma nephropathy large T antigen VP1 complications congenital heart disease ECMO extracorporeal life support mortality risk factors single ventricle BOLD signal variability pediatrics biomarker fMRI neurodevelopment grip strength young children active play growth and development platelet-rich plasma rhein knee osteoarthritis Crohn’s disease intestinal ultrasonography contrast-enhanced ultrasound MR enterography depressive disorders cognitive function physical function dementia older people copepods lipidomics climate change oceanic food chain sentinel species patient blood management red blood cell transfusion hemoglobin retrospective study social isolation space radiation blood–brain barrier lateral ventricle n/a post-stroke depression behavioral tests social activity motor function antidepressants murine models of depression thema EDItEUR::A The Arts::AT Performing arts::ATD Theatre studies thema EDItEUR::A The Arts::AV Music Feature Paper in Physiology and Pathology |
| title | Feature Paper in Physiology and Pathology |
| title_full | Feature Paper in Physiology and Pathology |
| title_fullStr | Feature Paper in Physiology and Pathology |
| title_full_unstemmed | Feature Paper in Physiology and Pathology |
| title_short | Feature Paper in Physiology and Pathology |
| title_sort | feature paper in physiology and pathology |
| topic | kidney fibrosis chronic kidney disease TGFβR-1 flavonoids pharmacokinetics molecular docking molecular dynamics simulations retrospective cohort study kidney disease end-stage kidney disease vitamin D tuberculosis type 2 diabetes mellitus genetic susceptibility molecular chaperons heat shock factor 1 (HSF1) single nucleotide polymorphism gene expression protein folding unfolded protein response body mass index obesity sex dimorphism NF-κB signaling signaling dynamics cell-fate decision encoding and decoding cellular information human diseases prolyl hydroxylase domain-containing protein PHD protein Phd1 gene osteoblast chondrocyte knockout mice phenotype hypoxia-inducible factor endochondral bone formation MRI prefrontal areas putamen gray matter volume specific phobia cognition rice intake adults Qatar Biobank study Neoplasia exercise sensitivity chemotherapy measurement of results reported by the patient biomechanics osteoarthritis cartilage musculoskeletal simulation probabilistic modelling experimental autoimmune encephalomyelitis colitis growth factors nematode adaptation angiogenesis knee joint biomarkers extracellular vesicles sepsis coagulation disseminated intravascular coagulation sepsis-induced coagulopathy laboratory evaluation guidelines cell competition cellular Potts model invasion travelling wave neutrophil extracellular traps peripheral blood infection digital white blood cell differential genetic disease prevalence penetrance accurate diagnosis disease iceberg effect cumulative lifetime risk familial aggregation ozone ozone therapy oxidative stress antioxidants defense inflammation dupilumab biologic dermatitis lichen amyloidosis primary cutaneous amyloidosis primary localized cutaneous amyloidosis IgG4-related disease IgG4-related skin disease immunoglobulin G4-related disease immunoglobulin G4-related skin disease WNT16 chondrocytes mice chondrogenesis cell culture subarachnoid hemorrhage bone-marrow mesenchymal stem cells cognitive impairment high-mobility group box 1 central centrifugal cicatricial alopecia scarring alopecia pediatric scarring hair loss skin of colour public health ambulatory blood pressure antihypertensive therapy peritoneal dialysis sex differences geranylgeraniol GGOH bisphosphonates medication-related osteonecrosis of the jaw MRONJ mevalonate pathway platelets PEVs hemostasis wound healing carcinogenesis therapy imidacloprid apoptosis telencephalon zebrafish serous endometrial intraepithelial carcinoma SEIC MUSC adjuvant therapy relapse BK-polyomavirus decoy cell polyoma nephropathy large T antigen VP1 complications congenital heart disease ECMO extracorporeal life support mortality risk factors single ventricle BOLD signal variability pediatrics biomarker fMRI neurodevelopment grip strength young children active play growth and development platelet-rich plasma rhein knee osteoarthritis Crohn’s disease intestinal ultrasonography contrast-enhanced ultrasound MR enterography depressive disorders cognitive function physical function dementia older people copepods lipidomics climate change oceanic food chain sentinel species patient blood management red blood cell transfusion hemoglobin retrospective study social isolation space radiation blood–brain barrier lateral ventricle n/a post-stroke depression behavioral tests social activity motor function antidepressants murine models of depression thema EDItEUR::A The Arts::AT Performing arts::ATD Theatre studies thema EDItEUR::A The Arts::AV Music |
| topic_facet | kidney fibrosis chronic kidney disease TGFβR-1 flavonoids pharmacokinetics molecular docking molecular dynamics simulations retrospective cohort study kidney disease end-stage kidney disease vitamin D tuberculosis type 2 diabetes mellitus genetic susceptibility molecular chaperons heat shock factor 1 (HSF1) single nucleotide polymorphism gene expression protein folding unfolded protein response body mass index obesity sex dimorphism NF-κB signaling signaling dynamics cell-fate decision encoding and decoding cellular information human diseases prolyl hydroxylase domain-containing protein PHD protein Phd1 gene osteoblast chondrocyte knockout mice phenotype hypoxia-inducible factor endochondral bone formation MRI prefrontal areas putamen gray matter volume specific phobia cognition rice intake adults Qatar Biobank study Neoplasia exercise sensitivity chemotherapy measurement of results reported by the patient biomechanics osteoarthritis cartilage musculoskeletal simulation probabilistic modelling experimental autoimmune encephalomyelitis colitis growth factors nematode adaptation angiogenesis knee joint biomarkers extracellular vesicles sepsis coagulation disseminated intravascular coagulation sepsis-induced coagulopathy laboratory evaluation guidelines cell competition cellular Potts model invasion travelling wave neutrophil extracellular traps peripheral blood infection digital white blood cell differential genetic disease prevalence penetrance accurate diagnosis disease iceberg effect cumulative lifetime risk familial aggregation ozone ozone therapy oxidative stress antioxidants defense inflammation dupilumab biologic dermatitis lichen amyloidosis primary cutaneous amyloidosis primary localized cutaneous amyloidosis IgG4-related disease IgG4-related skin disease immunoglobulin G4-related disease immunoglobulin G4-related skin disease WNT16 chondrocytes mice chondrogenesis cell culture subarachnoid hemorrhage bone-marrow mesenchymal stem cells cognitive impairment high-mobility group box 1 central centrifugal cicatricial alopecia scarring alopecia pediatric scarring hair loss skin of colour public health ambulatory blood pressure antihypertensive therapy peritoneal dialysis sex differences geranylgeraniol GGOH bisphosphonates medication-related osteonecrosis of the jaw MRONJ mevalonate pathway platelets PEVs hemostasis wound healing carcinogenesis therapy imidacloprid apoptosis telencephalon zebrafish serous endometrial intraepithelial carcinoma SEIC MUSC adjuvant therapy relapse BK-polyomavirus decoy cell polyoma nephropathy large T antigen VP1 complications congenital heart disease ECMO extracorporeal life support mortality risk factors single ventricle BOLD signal variability pediatrics biomarker fMRI neurodevelopment grip strength young children active play growth and development platelet-rich plasma rhein knee osteoarthritis Crohn’s disease intestinal ultrasonography contrast-enhanced ultrasound MR enterography depressive disorders cognitive function physical function dementia older people copepods lipidomics climate change oceanic food chain sentinel species patient blood management red blood cell transfusion hemoglobin retrospective study social isolation space radiation blood–brain barrier lateral ventricle n/a post-stroke depression behavioral tests social activity motor function antidepressants murine models of depression thema EDItEUR::A The Arts::AT Performing arts::ATD Theatre studies thema EDItEUR::A The Arts::AV Music |
| url | ONIX_20250220_9783725821761_150 |