Natural Compounds Applications in Drug Discovery and Development
Nature is a valuable source for the development and design of drug lead compounds that could significantly impact the treatment of serious diseases, enhancing health and wellbeing. Herbal systems play a fundamental role in healthcare, as 60% of chemotherapeutic agents are derived from natural source...
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| Materyal Türü: | Online |
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| Dil: | İngilizce |
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MDPI - Multidisciplinary Digital Publishing Institute
2025
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| Konular: | |
| Online Erişim: | ONIX_20250220_9783725822799_198 |
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| _version_ | 1869522070665166848 |
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| collection | Directory of Open Access Books |
| description | Nature is a valuable source for the development and design of drug lead compounds that could significantly impact the treatment of serious diseases, enhancing health and wellbeing. Herbal systems play a fundamental role in healthcare, as 60% of chemotherapeutic agents are derived from natural sources. The emergence of cutting-edge technologies and methods that improve the drug design process has provided new ways of processing complex natural products, using their structures to develop new and innovative drug candidates with superior properties. Current drug discovery and development trends focus on the latest applications of natural products in the fight against some of the most difficult-to-treat diseases. In this light, the Special Issue covers a wide range of topics that provide new insights into exploring the vast array of natural products and underlines the recent advances and applications in the field. The articles of the Special Issue emphasize researchers' efforts to combat various cancers, inflammation, and diabetes by applying extraction, synthesis, and computational techniques in conjunction with experimental testing to deliver better therapeutic candidates with fewer side effects, ultimately leading to safer, more effective, and affordable treatments for patients. By integrating advanced scientific techniques with natural biodiversity exploration, it ensures that the potential of natural products is fully explored in an attempt to address unmet medical needs. |
| format | Online |
| id | doab-20.500.12854ir-152834 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1528342025-02-20T13:08:52Z Natural Compounds Applications in Drug Discovery and Development Bora, Alina Crisan, Luminita red clover extraction methods biological activity HPLC phytochemical profile antimicrobial activity oxidative stress reduction anti-inflammatory activity ultrasound-assisted extraction innovative extraction methods betulinic acid−triazole derivatives antiproliferative cytotoxicity melanoma lung carcinoma colorectal adenocarcinoma Olea ferruginea Oleaceae ferruginan anti-inflammatory anti-diabetic molecular docking natural compound anticancer breast cancer caspase-3 Janus kinase1/STAT3 STITCH ADMET docking Mikania methyl-3,5-di-O-caffeoyl quinate cyclooxygenase human neutrophil elastase lipoxygenase vitamin E derivatives α-tocopheryloxyacetic acid (α-TEA) α-tocopheryl succinate (α-TS) cancer mitocans apoptosis anti-tubercular anti-cancer drug repurposing PLK1 pyrrolyl benzohydrazide derivative DPP-4 pharmacophore screening ADMETox DFT MLP natural products triazole derivatives betulin colorectal cancer betulinic acid betulinic acid derivatives liposomal formulation n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MN Surgery Nature is a valuable source for the development and design of drug lead compounds that could significantly impact the treatment of serious diseases, enhancing health and wellbeing. Herbal systems play a fundamental role in healthcare, as 60% of chemotherapeutic agents are derived from natural sources. The emergence of cutting-edge technologies and methods that improve the drug design process has provided new ways of processing complex natural products, using their structures to develop new and innovative drug candidates with superior properties. Current drug discovery and development trends focus on the latest applications of natural products in the fight against some of the most difficult-to-treat diseases. In this light, the Special Issue covers a wide range of topics that provide new insights into exploring the vast array of natural products and underlines the recent advances and applications in the field. The articles of the Special Issue emphasize researchers' efforts to combat various cancers, inflammation, and diabetes by applying extraction, synthesis, and computational techniques in conjunction with experimental testing to deliver better therapeutic candidates with fewer side effects, ultimately leading to safer, more effective, and affordable treatments for patients. By integrating advanced scientific techniques with natural biodiversity exploration, it ensures that the potential of natural products is fully explored in an attempt to address unmet medical needs. 2025-02-20T13:08:50Z 2025-02-20T13:08:50Z 2024 book ONIX_20250220_9783725822799_198 9783725822799 9783725822805 https://directory.doabooks.org/handle/20.500.12854/152834 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/10245 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-2280-5 10.3390/books978-3-7258-2280-5 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725822799 9783725822805 204 Basel open access |
| spellingShingle | red clover extraction methods biological activity HPLC phytochemical profile antimicrobial activity oxidative stress reduction anti-inflammatory activity ultrasound-assisted extraction innovative extraction methods betulinic acid−triazole derivatives antiproliferative cytotoxicity melanoma lung carcinoma colorectal adenocarcinoma Olea ferruginea Oleaceae ferruginan anti-inflammatory anti-diabetic molecular docking natural compound anticancer breast cancer caspase-3 Janus kinase1/STAT3 STITCH ADMET docking Mikania methyl-3,5-di-O-caffeoyl quinate cyclooxygenase human neutrophil elastase lipoxygenase vitamin E derivatives α-tocopheryloxyacetic acid (α-TEA) α-tocopheryl succinate (α-TS) cancer mitocans apoptosis anti-tubercular anti-cancer drug repurposing PLK1 pyrrolyl benzohydrazide derivative DPP-4 pharmacophore screening ADMETox DFT MLP natural products triazole derivatives betulin colorectal cancer betulinic acid betulinic acid derivatives liposomal formulation n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MN Surgery Natural Compounds Applications in Drug Discovery and Development |
| title | Natural Compounds Applications in Drug Discovery and Development |
| title_full | Natural Compounds Applications in Drug Discovery and Development |
| title_fullStr | Natural Compounds Applications in Drug Discovery and Development |
| title_full_unstemmed | Natural Compounds Applications in Drug Discovery and Development |
| title_short | Natural Compounds Applications in Drug Discovery and Development |
| title_sort | natural compounds applications in drug discovery and development |
| topic | red clover extraction methods biological activity HPLC phytochemical profile antimicrobial activity oxidative stress reduction anti-inflammatory activity ultrasound-assisted extraction innovative extraction methods betulinic acid−triazole derivatives antiproliferative cytotoxicity melanoma lung carcinoma colorectal adenocarcinoma Olea ferruginea Oleaceae ferruginan anti-inflammatory anti-diabetic molecular docking natural compound anticancer breast cancer caspase-3 Janus kinase1/STAT3 STITCH ADMET docking Mikania methyl-3,5-di-O-caffeoyl quinate cyclooxygenase human neutrophil elastase lipoxygenase vitamin E derivatives α-tocopheryloxyacetic acid (α-TEA) α-tocopheryl succinate (α-TS) cancer mitocans apoptosis anti-tubercular anti-cancer drug repurposing PLK1 pyrrolyl benzohydrazide derivative DPP-4 pharmacophore screening ADMETox DFT MLP natural products triazole derivatives betulin colorectal cancer betulinic acid betulinic acid derivatives liposomal formulation n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MN Surgery |
| topic_facet | red clover extraction methods biological activity HPLC phytochemical profile antimicrobial activity oxidative stress reduction anti-inflammatory activity ultrasound-assisted extraction innovative extraction methods betulinic acid−triazole derivatives antiproliferative cytotoxicity melanoma lung carcinoma colorectal adenocarcinoma Olea ferruginea Oleaceae ferruginan anti-inflammatory anti-diabetic molecular docking natural compound anticancer breast cancer caspase-3 Janus kinase1/STAT3 STITCH ADMET docking Mikania methyl-3,5-di-O-caffeoyl quinate cyclooxygenase human neutrophil elastase lipoxygenase vitamin E derivatives α-tocopheryloxyacetic acid (α-TEA) α-tocopheryl succinate (α-TS) cancer mitocans apoptosis anti-tubercular anti-cancer drug repurposing PLK1 pyrrolyl benzohydrazide derivative DPP-4 pharmacophore screening ADMETox DFT MLP natural products triazole derivatives betulin colorectal cancer betulinic acid betulinic acid derivatives liposomal formulation n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MN Surgery |
| url | ONIX_20250220_9783725822799_198 |