Molecular Mechanisms and Therapies of Pancreatic Cancer
Pancreatic cancer (PC) is one of the most aggressive solid malignancies, with an overall 5-year survival rate of ~8%, and it is predicted to become the second leading cause of cancer-related death by 2030. PC progression and metastasis are strongly influenced by metabolic stress imposed by the tumor...
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| Aineistotyyppi: | Online |
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| Kieli: | englanti |
| Julkaistu: |
MDPI - Multidisciplinary Digital Publishing Institute
2025
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| Aiheet: | |
| Linkit: | ONIX_20250220_9783725822898_203 |
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| _version_ | 1869521378223325184 |
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| collection | Directory of Open Access Books |
| description | Pancreatic cancer (PC) is one of the most aggressive solid malignancies, with an overall 5-year survival rate of ~8%, and it is predicted to become the second leading cause of cancer-related death by 2030. PC progression and metastasis are strongly influenced by metabolic stress imposed by the tumor microenvironment (TME) due to limited oxygen and nutrient supply and unfavorable pH. In this context, deregulation and the reprogramming of energy metabolism are hallmarks of PC, which leads tumor cells to rewire their glucose, amino acid, and lipid metabolism on the basis of the bioenergetic and biosynthetic demands needed to survive and escape immunosurveillance. For this reason, exploiting cellular plasticity through the targeted reprogramming of metabolic features in PC could lead to the generation of promising and novel selective therapeutic approaches for patients’ treatment. |
| format | Online |
| id | doab-20.500.12854ir-152839 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1528392025-02-20T13:09:21Z Molecular Mechanisms and Therapies of Pancreatic Cancer Cave, Donatella Delle Luchini, Claudio pancreatic cancer metabolism cellular plasticity tumor microenvironment target therapy thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine::MBNS Epidemiology and Medical statistics Pancreatic cancer (PC) is one of the most aggressive solid malignancies, with an overall 5-year survival rate of ~8%, and it is predicted to become the second leading cause of cancer-related death by 2030. PC progression and metastasis are strongly influenced by metabolic stress imposed by the tumor microenvironment (TME) due to limited oxygen and nutrient supply and unfavorable pH. In this context, deregulation and the reprogramming of energy metabolism are hallmarks of PC, which leads tumor cells to rewire their glucose, amino acid, and lipid metabolism on the basis of the bioenergetic and biosynthetic demands needed to survive and escape immunosurveillance. For this reason, exploiting cellular plasticity through the targeted reprogramming of metabolic features in PC could lead to the generation of promising and novel selective therapeutic approaches for patients’ treatment. 2025-02-20T13:09:18Z 2025-02-20T13:09:18Z 2024 book ONIX_20250220_9783725822898_203 9783725822898 9783725822904 https://directory.doabooks.org/handle/20.500.12854/152839 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/10169 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-2290-4 10.3390/books978-3-7258-2290-4 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725822898 9783725822904 252 Basel open access |
| spellingShingle | pancreatic cancer metabolism cellular plasticity tumor microenvironment target therapy thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine::MBNS Epidemiology and Medical statistics Molecular Mechanisms and Therapies of Pancreatic Cancer |
| title | Molecular Mechanisms and Therapies of Pancreatic Cancer |
| title_full | Molecular Mechanisms and Therapies of Pancreatic Cancer |
| title_fullStr | Molecular Mechanisms and Therapies of Pancreatic Cancer |
| title_full_unstemmed | Molecular Mechanisms and Therapies of Pancreatic Cancer |
| title_short | Molecular Mechanisms and Therapies of Pancreatic Cancer |
| title_sort | molecular mechanisms and therapies of pancreatic cancer |
| topic | pancreatic cancer metabolism cellular plasticity tumor microenvironment target therapy thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine::MBNS Epidemiology and Medical statistics |
| topic_facet | pancreatic cancer metabolism cellular plasticity tumor microenvironment target therapy thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine::MBNS Epidemiology and Medical statistics |
| url | ONIX_20250220_9783725822898_203 |