Astrocytes in CNS Disorders
Over the past 30 years, astrocytes have emerged from a supporting role to co-starring with neurons and oligodendrocytes as players in CNS disorders. Dysfunction of astrocytes is now implicated in disorders once thought to be solely of neuronal origin, such as epilepsy, amyotrophic lateral sclerosis,...
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| Format: | Online |
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| Sprache: | Englisch |
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MDPI - Multidisciplinary Digital Publishing Institute
2025
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| Online-Zugang: | ONIX_20250220_9783725822973_207 |
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| description | Over the past 30 years, astrocytes have emerged from a supporting role to co-starring with neurons and oligodendrocytes as players in CNS disorders. Dysfunction of astrocytes is now implicated in disorders once thought to be solely of neuronal origin, such as epilepsy, amyotrophic lateral sclerosis, and depression. It is also implicated in disorders previously ascribed solely to oligodendrocytes, like multiple sclerosis, vanishing white matter disease, and megalencephalic leukoencephalopathy with subcortical cysts. In some instances, the disease cause is a defect originating in astrocytes. The first and perhaps most definitive example is Alexander disease, in which coding mutations in the GFAP gene can cause massive dysmyelination and perturb multiple neuronal circuits. In other instances, induced disruption of normal astrocyte functions, such as glutamate or potassium transport, exacerbates the disease process. The purpose of this Special Issue is to illustrate the broad-ranging involvement of astrocytes in CNS disorders. Understanding their role in a variety of CNS disorders will be informative both for revealing normal interactions between astrocytes and other CNS cell types, and for identifying therapeutic targets. |
| format | Online |
| id | doab-20.500.12854ir-152843 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1528432025-02-20T13:09:42Z Astrocytes in CNS Disorders Brenner, Michael Parpura, Vladimir astrocytes CNS disease neurodegeneration neuroprotection novel therapeutic targets thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Over the past 30 years, astrocytes have emerged from a supporting role to co-starring with neurons and oligodendrocytes as players in CNS disorders. Dysfunction of astrocytes is now implicated in disorders once thought to be solely of neuronal origin, such as epilepsy, amyotrophic lateral sclerosis, and depression. It is also implicated in disorders previously ascribed solely to oligodendrocytes, like multiple sclerosis, vanishing white matter disease, and megalencephalic leukoencephalopathy with subcortical cysts. In some instances, the disease cause is a defect originating in astrocytes. The first and perhaps most definitive example is Alexander disease, in which coding mutations in the GFAP gene can cause massive dysmyelination and perturb multiple neuronal circuits. In other instances, induced disruption of normal astrocyte functions, such as glutamate or potassium transport, exacerbates the disease process. The purpose of this Special Issue is to illustrate the broad-ranging involvement of astrocytes in CNS disorders. Understanding their role in a variety of CNS disorders will be informative both for revealing normal interactions between astrocytes and other CNS cell types, and for identifying therapeutic targets. 2025-02-20T13:09:40Z 2025-02-20T13:09:40Z 2024 book ONIX_20250220_9783725822973_207 9783725822973 9783725822980 https://directory.doabooks.org/handle/20.500.12854/152843 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/10122 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-2298-0 10.3390/books978-3-7258-2298-0 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725822973 9783725822980 468 Basel open access |
| spellingShingle | astrocytes CNS disease neurodegeneration neuroprotection novel therapeutic targets thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Astrocytes in CNS Disorders |
| title | Astrocytes in CNS Disorders |
| title_full | Astrocytes in CNS Disorders |
| title_fullStr | Astrocytes in CNS Disorders |
| title_full_unstemmed | Astrocytes in CNS Disorders |
| title_short | Astrocytes in CNS Disorders |
| title_sort | astrocytes in cns disorders |
| topic | astrocytes CNS disease neurodegeneration neuroprotection novel therapeutic targets thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | astrocytes CNS disease neurodegeneration neuroprotection novel therapeutic targets thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | ONIX_20250220_9783725822973_207 |