The Role of Toll-Like Receptors (TLRs) in Infection and Inflammation 2.0
This Special Issue 2.0 continues the conceptional line started in the previous Special Issue, focusing on the involvement of Toll-like receptors (TLRs) and their related signaling pathways in viral infection and inflammation, and emphasizing the therapeutic potential of TLR system modulation for the...
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MDPI - Multidisciplinary Digital Publishing Institute
2025
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| description | This Special Issue 2.0 continues the conceptional line started in the previous Special Issue, focusing on the involvement of Toll-like receptors (TLRs) and their related signaling pathways in viral infection and inflammation, and emphasizing the therapeutic potential of TLR system modulation for the treatment of acute viral infections and their long-term sequelae and to provide potential targets for treating chronic viral and inflammatory diseases. This Special Issue provides an excellent collection of contemporary reviews and research articles covering a broad variety of topics, ranging from the protective activity of TLRs in viral infections to detrimental disturbances of the host immune system. The most intriguing theme discussed in this second Special Issue is the intercorrelation between acute viral infections and triggered delayed effects, including neuroinflammatory and neurodegenerative long-term sequelae. Notably, new data increasingly show that neurological pathways, such as neurogenesis, neuroinflammation, and cognitive and behavioural aspects, may be influenced by innate, TLR-mediated pathways. In this context, the connection between infection-triggered acute disbalance in TLR activation and resulting neurological sequelae following bacterial (sepsis) or viral infections, including long COVID-associated neurological sequelae, may provide new targets for future treatment options. |
| format | Online |
| id | doab-20.500.12854ir-152864 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1528642025-02-20T13:11:41Z The Role of Toll-Like Receptors (TLRs) in Infection and Inflammation 2.0 Kircheis, Ralf Planz, Oliver Toll-like receptor COVID-19 SARS-CoV-2 innate immunity host genetics MYD88 CCL4 CCL20 CCR2 atherosclerosis statin toll-like receptor TLR agonist HIV-1 co-infection HBV HCV Toll-like receptor 2 dimerization homodimerization heterodimerization inflammation neuroinflammation neurodegeneration TLRs TLR-4 lethal COVID-19 lung disease macrophage shift ARDS CD68 galectin-3 CD163 M1 macrophages M2 macrophages immune-to-brain communication lung–brain axis lipopolysaccharide acute respiratory distress syndrome cytokines lipid mediators omega-3 fatty acids resolvin E1 receptors TNFα cfDNA TLR (toll-like receptor) 9 cathelicidin anti-microbial peptide adipocyte adipose tissue Toll-like receptors immunity adaptive immunity ligands toll-like receptor (TLR) myeloid differentiation factor-2 (MD-2) TLR4/MD-2 Omicron spike protein cytokine storm NF-kappa B TLR brain neurogenesis blood–brain barrier behavior cognition TLR7 NOD2 synergy type I IFN experimental autoimmune encephalomyelitis complement C5a sepsis heart dysfunction arrhythmia cardiomyocytes neutrophils n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences This Special Issue 2.0 continues the conceptional line started in the previous Special Issue, focusing on the involvement of Toll-like receptors (TLRs) and their related signaling pathways in viral infection and inflammation, and emphasizing the therapeutic potential of TLR system modulation for the treatment of acute viral infections and their long-term sequelae and to provide potential targets for treating chronic viral and inflammatory diseases. This Special Issue provides an excellent collection of contemporary reviews and research articles covering a broad variety of topics, ranging from the protective activity of TLRs in viral infections to detrimental disturbances of the host immune system. The most intriguing theme discussed in this second Special Issue is the intercorrelation between acute viral infections and triggered delayed effects, including neuroinflammatory and neurodegenerative long-term sequelae. Notably, new data increasingly show that neurological pathways, such as neurogenesis, neuroinflammation, and cognitive and behavioural aspects, may be influenced by innate, TLR-mediated pathways. In this context, the connection between infection-triggered acute disbalance in TLR activation and resulting neurological sequelae following bacterial (sepsis) or viral infections, including long COVID-associated neurological sequelae, may provide new targets for future treatment options. 2025-02-20T13:11:38Z 2025-02-20T13:11:38Z 2024 book ONIX_20250220_9783725823444_228 9783725823444 9783725823437 https://directory.doabooks.org/handle/20.500.12854/152864 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/10053 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-2343-7 10.3390/books978-3-7258-2343-7 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725823444 9783725823437 264 Basel open access |
| spellingShingle | Toll-like receptor COVID-19 SARS-CoV-2 innate immunity host genetics MYD88 CCL4 CCL20 CCR2 atherosclerosis statin toll-like receptor TLR agonist HIV-1 co-infection HBV HCV Toll-like receptor 2 dimerization homodimerization heterodimerization inflammation neuroinflammation neurodegeneration TLRs TLR-4 lethal COVID-19 lung disease macrophage shift ARDS CD68 galectin-3 CD163 M1 macrophages M2 macrophages immune-to-brain communication lung–brain axis lipopolysaccharide acute respiratory distress syndrome cytokines lipid mediators omega-3 fatty acids resolvin E1 receptors TNFα cfDNA TLR (toll-like receptor) 9 cathelicidin anti-microbial peptide adipocyte adipose tissue Toll-like receptors immunity adaptive immunity ligands toll-like receptor (TLR) myeloid differentiation factor-2 (MD-2) TLR4/MD-2 Omicron spike protein cytokine storm NF-kappa B TLR brain neurogenesis blood–brain barrier behavior cognition TLR7 NOD2 synergy type I IFN experimental autoimmune encephalomyelitis complement C5a sepsis heart dysfunction arrhythmia cardiomyocytes neutrophils n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences The Role of Toll-Like Receptors (TLRs) in Infection and Inflammation 2.0 |
| title | The Role of Toll-Like Receptors (TLRs) in Infection and Inflammation 2.0 |
| title_full | The Role of Toll-Like Receptors (TLRs) in Infection and Inflammation 2.0 |
| title_fullStr | The Role of Toll-Like Receptors (TLRs) in Infection and Inflammation 2.0 |
| title_full_unstemmed | The Role of Toll-Like Receptors (TLRs) in Infection and Inflammation 2.0 |
| title_short | The Role of Toll-Like Receptors (TLRs) in Infection and Inflammation 2.0 |
| title_sort | role of toll like receptors tlrs in infection and inflammation 2 0 |
| topic | Toll-like receptor COVID-19 SARS-CoV-2 innate immunity host genetics MYD88 CCL4 CCL20 CCR2 atherosclerosis statin toll-like receptor TLR agonist HIV-1 co-infection HBV HCV Toll-like receptor 2 dimerization homodimerization heterodimerization inflammation neuroinflammation neurodegeneration TLRs TLR-4 lethal COVID-19 lung disease macrophage shift ARDS CD68 galectin-3 CD163 M1 macrophages M2 macrophages immune-to-brain communication lung–brain axis lipopolysaccharide acute respiratory distress syndrome cytokines lipid mediators omega-3 fatty acids resolvin E1 receptors TNFα cfDNA TLR (toll-like receptor) 9 cathelicidin anti-microbial peptide adipocyte adipose tissue Toll-like receptors immunity adaptive immunity ligands toll-like receptor (TLR) myeloid differentiation factor-2 (MD-2) TLR4/MD-2 Omicron spike protein cytokine storm NF-kappa B TLR brain neurogenesis blood–brain barrier behavior cognition TLR7 NOD2 synergy type I IFN experimental autoimmune encephalomyelitis complement C5a sepsis heart dysfunction arrhythmia cardiomyocytes neutrophils n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | Toll-like receptor COVID-19 SARS-CoV-2 innate immunity host genetics MYD88 CCL4 CCL20 CCR2 atherosclerosis statin toll-like receptor TLR agonist HIV-1 co-infection HBV HCV Toll-like receptor 2 dimerization homodimerization heterodimerization inflammation neuroinflammation neurodegeneration TLRs TLR-4 lethal COVID-19 lung disease macrophage shift ARDS CD68 galectin-3 CD163 M1 macrophages M2 macrophages immune-to-brain communication lung–brain axis lipopolysaccharide acute respiratory distress syndrome cytokines lipid mediators omega-3 fatty acids resolvin E1 receptors TNFα cfDNA TLR (toll-like receptor) 9 cathelicidin anti-microbial peptide adipocyte adipose tissue Toll-like receptors immunity adaptive immunity ligands toll-like receptor (TLR) myeloid differentiation factor-2 (MD-2) TLR4/MD-2 Omicron spike protein cytokine storm NF-kappa B TLR brain neurogenesis blood–brain barrier behavior cognition TLR7 NOD2 synergy type I IFN experimental autoimmune encephalomyelitis complement C5a sepsis heart dysfunction arrhythmia cardiomyocytes neutrophils n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20250220_9783725823444_228 |