Exosomes in Cancers Therapy
In recent years, small extracellular vesicles (EVs), particularly exosomes, have emerged as new delivery vehicles in cancer treatment. These 30–150 nm vesicles play a critical role in cellular communication and also offer a new approach to drug delivery. Exosomes carry proteins, lipids, and nucleic...
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| 格式: | Online |
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| 語言: | 英语 |
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MDPI - Multidisciplinary Digital Publishing Institute
2025
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| 在線閱讀: | ONIX_20250220_9783725823475_230 |
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| _version_ | 1869522543636905984 |
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| collection | Directory of Open Access Books |
| description | In recent years, small extracellular vesicles (EVs), particularly exosomes, have emerged as new delivery vehicles in cancer treatment. These 30–150 nm vesicles play a critical role in cellular communication and also offer a new approach to drug delivery. Exosomes carry proteins, lipids, and nucleic acids, and their unique ability to naturally facilitate intercellular communication is opening up new possibilities for targeted drug delivery and immunotherapy in cancer treatment. While cancer-derived exosomes can contribute to tumor growth and metastasis, this same mechanism can be repurposed as a powerful therapeutic tool. Researchers are exploring their use as biomarkers for diagnosis and prognosis, as well as nano-carriers for delivering small molecules and biologics. Their ability to stabilize drugs, cross biological barriers such as the blood–brain barrier, and low toxicity make them especially attractive for therapeutic applications. This collection of articles focuses on the evolving role of exosomes in cancer therapy, highlighting their benefits and the problems with bringing them into clinical practice. Given the challenges in scaling up cell-derived exosomes for common use, bovine milk and colostrum have emerged as promising and abundant sources for exosome-based drug delivery systems. With their high exosome yield and established safety, milk-derived exosomes could become vital to the future of cancer treatment. The Special Issue also contains articles with preclinical and clinical studies, examining the potential of exosome-based platforms for the oral delivery of cancer drugs and biologics. |
| format | Online |
| id | doab-20.500.12854ir-152866 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1528662025-02-20T13:11:53Z Exosomes in Cancers Therapy Aqil, Farrukh Gupta, Ramesh tumor-derived exosomes exosomal cargoes protumorigenic effect drug resistance anticancer therapy antigen cancer exosomes immune response therapeutics acute myelogenous leukemia platelets microparticles apoptosis cancer diagnosis sensing early detection plasmonics nanoparticles surface-enhanced Raman spectroscopy extracellular vesicles cancer vaccine immunotherapy drug delivery gene delivery surface funzionalization hallmarks of cancer theranostics dendritic cells vaccines plasmacytoid DCs cancer immunotherapy colostrum exosomes paclitaxel lung cancer immunotoxicity assessment small extracellular vesicles breast cancer cancer aggressiveness multi-drug resistance diagnosis HSP70 tumor microenvironment immune modulation n/a thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues In recent years, small extracellular vesicles (EVs), particularly exosomes, have emerged as new delivery vehicles in cancer treatment. These 30–150 nm vesicles play a critical role in cellular communication and also offer a new approach to drug delivery. Exosomes carry proteins, lipids, and nucleic acids, and their unique ability to naturally facilitate intercellular communication is opening up new possibilities for targeted drug delivery and immunotherapy in cancer treatment. While cancer-derived exosomes can contribute to tumor growth and metastasis, this same mechanism can be repurposed as a powerful therapeutic tool. Researchers are exploring their use as biomarkers for diagnosis and prognosis, as well as nano-carriers for delivering small molecules and biologics. Their ability to stabilize drugs, cross biological barriers such as the blood–brain barrier, and low toxicity make them especially attractive for therapeutic applications. This collection of articles focuses on the evolving role of exosomes in cancer therapy, highlighting their benefits and the problems with bringing them into clinical practice. Given the challenges in scaling up cell-derived exosomes for common use, bovine milk and colostrum have emerged as promising and abundant sources for exosome-based drug delivery systems. With their high exosome yield and established safety, milk-derived exosomes could become vital to the future of cancer treatment. The Special Issue also contains articles with preclinical and clinical studies, examining the potential of exosome-based platforms for the oral delivery of cancer drugs and biologics. 2025-02-20T13:11:50Z 2025-02-20T13:11:50Z 2024 book ONIX_20250220_9783725823475_230 9783725823475 9783725823482 https://directory.doabooks.org/handle/20.500.12854/152866 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/10060 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-2348-2 10.3390/books978-3-7258-2348-2 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725823475 9783725823482 254 Basel open access |
| spellingShingle | tumor-derived exosomes exosomal cargoes protumorigenic effect drug resistance anticancer therapy antigen cancer exosomes immune response therapeutics acute myelogenous leukemia platelets microparticles apoptosis cancer diagnosis sensing early detection plasmonics nanoparticles surface-enhanced Raman spectroscopy extracellular vesicles cancer vaccine immunotherapy drug delivery gene delivery surface funzionalization hallmarks of cancer theranostics dendritic cells vaccines plasmacytoid DCs cancer immunotherapy colostrum exosomes paclitaxel lung cancer immunotoxicity assessment small extracellular vesicles breast cancer cancer aggressiveness multi-drug resistance diagnosis HSP70 tumor microenvironment immune modulation n/a thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues Exosomes in Cancers Therapy |
| title | Exosomes in Cancers Therapy |
| title_full | Exosomes in Cancers Therapy |
| title_fullStr | Exosomes in Cancers Therapy |
| title_full_unstemmed | Exosomes in Cancers Therapy |
| title_short | Exosomes in Cancers Therapy |
| title_sort | exosomes in cancers therapy |
| topic | tumor-derived exosomes exosomal cargoes protumorigenic effect drug resistance anticancer therapy antigen cancer exosomes immune response therapeutics acute myelogenous leukemia platelets microparticles apoptosis cancer diagnosis sensing early detection plasmonics nanoparticles surface-enhanced Raman spectroscopy extracellular vesicles cancer vaccine immunotherapy drug delivery gene delivery surface funzionalization hallmarks of cancer theranostics dendritic cells vaccines plasmacytoid DCs cancer immunotherapy colostrum exosomes paclitaxel lung cancer immunotoxicity assessment small extracellular vesicles breast cancer cancer aggressiveness multi-drug resistance diagnosis HSP70 tumor microenvironment immune modulation n/a thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues |
| topic_facet | tumor-derived exosomes exosomal cargoes protumorigenic effect drug resistance anticancer therapy antigen cancer exosomes immune response therapeutics acute myelogenous leukemia platelets microparticles apoptosis cancer diagnosis sensing early detection plasmonics nanoparticles surface-enhanced Raman spectroscopy extracellular vesicles cancer vaccine immunotherapy drug delivery gene delivery surface funzionalization hallmarks of cancer theranostics dendritic cells vaccines plasmacytoid DCs cancer immunotherapy colostrum exosomes paclitaxel lung cancer immunotoxicity assessment small extracellular vesicles breast cancer cancer aggressiveness multi-drug resistance diagnosis HSP70 tumor microenvironment immune modulation n/a thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues |
| url | ONIX_20250220_9783725823475_230 |