Enzyme Inhibitors from Marine Resources
Marine living organisms and their main and secondary compounds and metabolites are among the richest in biological diversity. Many of their fundamental qualities and applications are still fully or partially unexplored. Given that enzymes are essential in the plethora of biological functions of thes...
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| Aineistotyyppi: | Online |
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| Kieli: | englanti |
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MDPI - Multidisciplinary Digital Publishing Institute
2025
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| Linkit: | ONIX_20250220_9783725824458_278 |
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| description | Marine living organisms and their main and secondary compounds and metabolites are among the richest in biological diversity. Many of their fundamental qualities and applications are still fully or partially unexplored. Given that enzymes are essential in the plethora of biological functions of these organisms, it is increasingly evident that enzyme inhibitors are also involved in the control of these functions, as well as in many diseases and attack–defense processes. Research on the natural inhibitors found in marine organisms is, therefore, of great interest at present in a myriad of research perspectives. The present Special Issue collected novel research on non-peptide or peptide/protein inhibitors, or derived forms, with a focus on isolation, structure-function characterization, methods of action, variety, evolution, screening, and genomics–proteomics. Particular emphasis is placed on enzyme inhibitors from marine invertebrates, microorganisms, and algae, still not well understood. Additionally, studies on the potential value of such molecules for biological, biotechnological, and pharmaceutical/biomedical uses, particularly as drugs or lead compounds, are taken into account. |
| format | Online |
| id | doab-20.500.12854ir-152914 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1529142025-02-20T13:16:40Z Enzyme Inhibitors from Marine Resources Avilés, Francesc Xavier Pascual Alonso, Isel Gracilaria lemaneiformis polysaccharide degradation optimization chemical characteristics hypolipidemic activity α-glucosidase Streptomyces sp. HO1518 metabolic profiling aminooligosaccharides UPLC-QTOF-MS/MS diabetes digestive enzyme inhibitors α-N-acetylgalactosaminidase α-NaGalase inhibitor phlorotannins brown algae Costaria costata carcinoma melanoma cancer cells enzyme inhibitors PBP, penicillin-binding protein β-lactonase salinosporamide AHL, N-acylhomoserine lactone quorum quenching metallocarboxipeptidases carboxypeptidase inhibitor slow- and tight-binding inhibitor marine invertebrate Plasmodium falciparum antimalarial databases cheminformatics natural products gorgonian soft coral enzyme kinetics inhibitor characterization STRENDA guidelines aminopeptidase aminopeptidase N aminopeptidase A TRH-degrading ectoenzyme leucyl aminopeptidase drug-oriented inhibitors marine invertebrates Porphyridium sp. peptides cyclooxygenase enzymes hypertension inflammation animal health spontaneously hypertensive rats pain relief hydrothermal vent mussel Gigantidas vrijenhoeki angiotensin I-converting enzyme molecular docking bioactive peptide thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MN Surgery Marine living organisms and their main and secondary compounds and metabolites are among the richest in biological diversity. Many of their fundamental qualities and applications are still fully or partially unexplored. Given that enzymes are essential in the plethora of biological functions of these organisms, it is increasingly evident that enzyme inhibitors are also involved in the control of these functions, as well as in many diseases and attack–defense processes. Research on the natural inhibitors found in marine organisms is, therefore, of great interest at present in a myriad of research perspectives. The present Special Issue collected novel research on non-peptide or peptide/protein inhibitors, or derived forms, with a focus on isolation, structure-function characterization, methods of action, variety, evolution, screening, and genomics–proteomics. Particular emphasis is placed on enzyme inhibitors from marine invertebrates, microorganisms, and algae, still not well understood. Additionally, studies on the potential value of such molecules for biological, biotechnological, and pharmaceutical/biomedical uses, particularly as drugs or lead compounds, are taken into account. 2025-02-20T13:16:37Z 2025-02-20T13:16:37Z 2024 book ONIX_20250220_9783725824458_278 9783725824458 9783725824465 https://directory.doabooks.org/handle/20.500.12854/152914 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/10328 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-2446-5 10.3390/books978-3-7258-2446-5 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725824458 9783725824465 220 Basel open access |
| spellingShingle | Gracilaria lemaneiformis polysaccharide degradation optimization chemical characteristics hypolipidemic activity α-glucosidase Streptomyces sp. HO1518 metabolic profiling aminooligosaccharides UPLC-QTOF-MS/MS diabetes digestive enzyme inhibitors α-N-acetylgalactosaminidase α-NaGalase inhibitor phlorotannins brown algae Costaria costata carcinoma melanoma cancer cells enzyme inhibitors PBP, penicillin-binding protein β-lactonase salinosporamide AHL, N-acylhomoserine lactone quorum quenching metallocarboxipeptidases carboxypeptidase inhibitor slow- and tight-binding inhibitor marine invertebrate Plasmodium falciparum antimalarial databases cheminformatics natural products gorgonian soft coral enzyme kinetics inhibitor characterization STRENDA guidelines aminopeptidase aminopeptidase N aminopeptidase A TRH-degrading ectoenzyme leucyl aminopeptidase drug-oriented inhibitors marine invertebrates Porphyridium sp. peptides cyclooxygenase enzymes hypertension inflammation animal health spontaneously hypertensive rats pain relief hydrothermal vent mussel Gigantidas vrijenhoeki angiotensin I-converting enzyme molecular docking bioactive peptide thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MN Surgery Enzyme Inhibitors from Marine Resources |
| title | Enzyme Inhibitors from Marine Resources |
| title_full | Enzyme Inhibitors from Marine Resources |
| title_fullStr | Enzyme Inhibitors from Marine Resources |
| title_full_unstemmed | Enzyme Inhibitors from Marine Resources |
| title_short | Enzyme Inhibitors from Marine Resources |
| title_sort | enzyme inhibitors from marine resources |
| topic | Gracilaria lemaneiformis polysaccharide degradation optimization chemical characteristics hypolipidemic activity α-glucosidase Streptomyces sp. HO1518 metabolic profiling aminooligosaccharides UPLC-QTOF-MS/MS diabetes digestive enzyme inhibitors α-N-acetylgalactosaminidase α-NaGalase inhibitor phlorotannins brown algae Costaria costata carcinoma melanoma cancer cells enzyme inhibitors PBP, penicillin-binding protein β-lactonase salinosporamide AHL, N-acylhomoserine lactone quorum quenching metallocarboxipeptidases carboxypeptidase inhibitor slow- and tight-binding inhibitor marine invertebrate Plasmodium falciparum antimalarial databases cheminformatics natural products gorgonian soft coral enzyme kinetics inhibitor characterization STRENDA guidelines aminopeptidase aminopeptidase N aminopeptidase A TRH-degrading ectoenzyme leucyl aminopeptidase drug-oriented inhibitors marine invertebrates Porphyridium sp. peptides cyclooxygenase enzymes hypertension inflammation animal health spontaneously hypertensive rats pain relief hydrothermal vent mussel Gigantidas vrijenhoeki angiotensin I-converting enzyme molecular docking bioactive peptide thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MN Surgery |
| topic_facet | Gracilaria lemaneiformis polysaccharide degradation optimization chemical characteristics hypolipidemic activity α-glucosidase Streptomyces sp. HO1518 metabolic profiling aminooligosaccharides UPLC-QTOF-MS/MS diabetes digestive enzyme inhibitors α-N-acetylgalactosaminidase α-NaGalase inhibitor phlorotannins brown algae Costaria costata carcinoma melanoma cancer cells enzyme inhibitors PBP, penicillin-binding protein β-lactonase salinosporamide AHL, N-acylhomoserine lactone quorum quenching metallocarboxipeptidases carboxypeptidase inhibitor slow- and tight-binding inhibitor marine invertebrate Plasmodium falciparum antimalarial databases cheminformatics natural products gorgonian soft coral enzyme kinetics inhibitor characterization STRENDA guidelines aminopeptidase aminopeptidase N aminopeptidase A TRH-degrading ectoenzyme leucyl aminopeptidase drug-oriented inhibitors marine invertebrates Porphyridium sp. peptides cyclooxygenase enzymes hypertension inflammation animal health spontaneously hypertensive rats pain relief hydrothermal vent mussel Gigantidas vrijenhoeki angiotensin I-converting enzyme molecular docking bioactive peptide thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MN Surgery |
| url | ONIX_20250220_9783725824458_278 |