New Diagnostic and Therapeutic Approaches in Diabetic Microvascular Complications
Diabetes mellitus is a major health problem globally, with an ascendant trend, and is expected to reach up to 700 million cases by 2045. The microvascular triad includes diabetic retinopathy, nephropathy, and neuropathy, unique in diabetes. Despite significant achievements in early diagnosis and the...
שמור ב:
| פורמט: | Online |
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| שפה: | אנגלית |
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MDPI - Multidisciplinary Digital Publishing Institute
2025
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| נושאים: | |
| גישה מקוונת: | ONIX_20250220_9783725824991_303 |
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| _version_ | 1869515825622286336 |
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| collection | Directory of Open Access Books |
| description | Diabetes mellitus is a major health problem globally, with an ascendant trend, and is expected to reach up to 700 million cases by 2045. The microvascular triad includes diabetic retinopathy, nephropathy, and neuropathy, unique in diabetes. Despite significant achievements in early diagnosis and therapy, diabetic retinopathy remains the leading cause of blindness in the working-age population, with a severe impact on patients' quality of life. Diabetic peripheral neuropathy affects nearly 50% of adults with diabetes during their lifetime, and it represents a major risk factor for diabetic foot ulcers (DFUs), the most common cause of non-traumatic amputations worldwide. Classically, the duration of diabetes, level of hyperglycemia, arterial hypertension, and dyslipidemia are the most implicated risk factors. Novel research has found multiple molecular pathways that may interfere with vascular disfunction, ischemia, and tissular damage. In this Special Issue, we showcase nine original articles and two comprehensive reviews that provide new data on novel biomarkers, early diagnosis, pathology, molecular mechanisms, and new therapies in the fields of diabetic retinopathy, nephropathy, neuropathy, and diabetic foot ulcers. |
| format | Online |
| id | doab-20.500.12854ir-152939 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1529392025-02-20T13:18:57Z New Diagnostic and Therapeutic Approaches in Diabetic Microvascular Complications Dascalu, Ana Maria Serban, Dragos diabetic retinopathy biomarkers neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte ratio (PLR) monocyte-to-lymphocyte ratio (MLR) systemic inflammation index (SII) RepSox endothelial cells permeability diabetes retinopathy anti-VEGF cytokines skin autofluorescence type 2 diabetes diabetic kidney disease albuminuria tubular injury L-FABP proliferative diabetic retinopathy microvasculature vessel density OCTA foveal avascular zone panretinal photocoagulation type 1 diabetes metabolic syndrome endotoxin low-grade inflammation lipopolysaccharide-binding protein endogenous anti-endotoxin core antibodies full-field ERG diabetes mellitus enlarged perivascular spaces glymphatic system obesity neurovascular unit perivascular unit perivascular space postcapillary venules precapillary arterioles type 2 diabetes mellitus Advanced Glycation End Products (AGEs) type 2 diabetes mellitus (T2DM) cardiovascular risk Ang1 Ang2 ANGPTL8 ANGPTL4 DN postprandial non-fasting fasting glucose prediabetes pregnancy maternal HPA axis fetal HPA axis programming fetal development placenta glucocorticoids metabolic diseases n/a thema EDItEUR::M Medicine and Nursing Diabetes mellitus is a major health problem globally, with an ascendant trend, and is expected to reach up to 700 million cases by 2045. The microvascular triad includes diabetic retinopathy, nephropathy, and neuropathy, unique in diabetes. Despite significant achievements in early diagnosis and therapy, diabetic retinopathy remains the leading cause of blindness in the working-age population, with a severe impact on patients' quality of life. Diabetic peripheral neuropathy affects nearly 50% of adults with diabetes during their lifetime, and it represents a major risk factor for diabetic foot ulcers (DFUs), the most common cause of non-traumatic amputations worldwide. Classically, the duration of diabetes, level of hyperglycemia, arterial hypertension, and dyslipidemia are the most implicated risk factors. Novel research has found multiple molecular pathways that may interfere with vascular disfunction, ischemia, and tissular damage. In this Special Issue, we showcase nine original articles and two comprehensive reviews that provide new data on novel biomarkers, early diagnosis, pathology, molecular mechanisms, and new therapies in the fields of diabetic retinopathy, nephropathy, neuropathy, and diabetic foot ulcers. 2025-02-20T13:18:55Z 2025-02-20T13:18:55Z 2024 book ONIX_20250220_9783725824991_303 9783725824991 9783725825004 https://directory.doabooks.org/handle/20.500.12854/152939 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/10250 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-2500-4 10.3390/books978-3-7258-2500-4 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725824991 9783725825004 190 Basel open access |
| spellingShingle | diabetic retinopathy biomarkers neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte ratio (PLR) monocyte-to-lymphocyte ratio (MLR) systemic inflammation index (SII) RepSox endothelial cells permeability diabetes retinopathy anti-VEGF cytokines skin autofluorescence type 2 diabetes diabetic kidney disease albuminuria tubular injury L-FABP proliferative diabetic retinopathy microvasculature vessel density OCTA foveal avascular zone panretinal photocoagulation type 1 diabetes metabolic syndrome endotoxin low-grade inflammation lipopolysaccharide-binding protein endogenous anti-endotoxin core antibodies full-field ERG diabetes mellitus enlarged perivascular spaces glymphatic system obesity neurovascular unit perivascular unit perivascular space postcapillary venules precapillary arterioles type 2 diabetes mellitus Advanced Glycation End Products (AGEs) type 2 diabetes mellitus (T2DM) cardiovascular risk Ang1 Ang2 ANGPTL8 ANGPTL4 DN postprandial non-fasting fasting glucose prediabetes pregnancy maternal HPA axis fetal HPA axis programming fetal development placenta glucocorticoids metabolic diseases n/a thema EDItEUR::M Medicine and Nursing New Diagnostic and Therapeutic Approaches in Diabetic Microvascular Complications |
| title | New Diagnostic and Therapeutic Approaches in Diabetic Microvascular Complications |
| title_full | New Diagnostic and Therapeutic Approaches in Diabetic Microvascular Complications |
| title_fullStr | New Diagnostic and Therapeutic Approaches in Diabetic Microvascular Complications |
| title_full_unstemmed | New Diagnostic and Therapeutic Approaches in Diabetic Microvascular Complications |
| title_short | New Diagnostic and Therapeutic Approaches in Diabetic Microvascular Complications |
| title_sort | new diagnostic and therapeutic approaches in diabetic microvascular complications |
| topic | diabetic retinopathy biomarkers neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte ratio (PLR) monocyte-to-lymphocyte ratio (MLR) systemic inflammation index (SII) RepSox endothelial cells permeability diabetes retinopathy anti-VEGF cytokines skin autofluorescence type 2 diabetes diabetic kidney disease albuminuria tubular injury L-FABP proliferative diabetic retinopathy microvasculature vessel density OCTA foveal avascular zone panretinal photocoagulation type 1 diabetes metabolic syndrome endotoxin low-grade inflammation lipopolysaccharide-binding protein endogenous anti-endotoxin core antibodies full-field ERG diabetes mellitus enlarged perivascular spaces glymphatic system obesity neurovascular unit perivascular unit perivascular space postcapillary venules precapillary arterioles type 2 diabetes mellitus Advanced Glycation End Products (AGEs) type 2 diabetes mellitus (T2DM) cardiovascular risk Ang1 Ang2 ANGPTL8 ANGPTL4 DN postprandial non-fasting fasting glucose prediabetes pregnancy maternal HPA axis fetal HPA axis programming fetal development placenta glucocorticoids metabolic diseases n/a thema EDItEUR::M Medicine and Nursing |
| topic_facet | diabetic retinopathy biomarkers neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte ratio (PLR) monocyte-to-lymphocyte ratio (MLR) systemic inflammation index (SII) RepSox endothelial cells permeability diabetes retinopathy anti-VEGF cytokines skin autofluorescence type 2 diabetes diabetic kidney disease albuminuria tubular injury L-FABP proliferative diabetic retinopathy microvasculature vessel density OCTA foveal avascular zone panretinal photocoagulation type 1 diabetes metabolic syndrome endotoxin low-grade inflammation lipopolysaccharide-binding protein endogenous anti-endotoxin core antibodies full-field ERG diabetes mellitus enlarged perivascular spaces glymphatic system obesity neurovascular unit perivascular unit perivascular space postcapillary venules precapillary arterioles type 2 diabetes mellitus Advanced Glycation End Products (AGEs) type 2 diabetes mellitus (T2DM) cardiovascular risk Ang1 Ang2 ANGPTL8 ANGPTL4 DN postprandial non-fasting fasting glucose prediabetes pregnancy maternal HPA axis fetal HPA axis programming fetal development placenta glucocorticoids metabolic diseases n/a thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20250220_9783725824991_303 |