Synthesis of Natural Products Using Engineered Plants and Microorganisms
Plants and microorganisms, particularly medicinal herbs, harbor a diverse array of natural products. Many of these are bioactive molecules with potential applications in pharmaceuticals and healthcare. However, the concentrations of these bioactive compounds in plants or microorganisms are usually l...
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| Format: | Online |
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| Jezik: | angleščina |
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MDPI - Multidisciplinary Digital Publishing Institute
2025
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| Online dostop: | ONIX_20250220_9783725826063_353 |
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| _version_ | 1869522689509556224 |
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| collection | Directory of Open Access Books |
| description | Plants and microorganisms, particularly medicinal herbs, harbor a diverse array of natural products. Many of these are bioactive molecules with potential applications in pharmaceuticals and healthcare. However, the concentrations of these bioactive compounds in plants or microorganisms are usually low. The advancement of omics technologies and synthetic biology has opened up new possibilities for producing these bioactive molecules through the metabolic engineering of plants and microorganisms. Especially substances like artemisinin, rare ginsenosides, and several other natural products have already been successfully manufactured on a large scale. This reprint aims to provide an overview of the current state-of-the-art synthetic biology and engineering biology technologies used in plants and microorganisms for the biosynthesis and scalable production of natural products. |
| format | Online |
| id | doab-20.500.12854ir-152989 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
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| spelling | doab-20.500.12854ir-1529892025-02-20T13:23:31Z Synthesis of Natural Products Using Engineered Plants and Microorganisms Wei, Yongjun Qu, Lingbo Ji, Xiao-Jun Citrus reticulata ‘chachi’ transcriptome metabolome flavonoid Artemisia annua artemisinin synthetic biology genetic engineering transcription factor Ganoderma luteomarginatum lanostane triterpenoids ergostane steroids cytotoxic activity excision wound epithelization essential oils wound healing biological nano selenium nutritional composition antioxidant stress organic selenium ABC transporter family Epimedium flavonoids pharmacological activities extraction methods biotransformation biosynthesis L-cysteine metabolic engineering fermentation fed-batch process downstream processing Ardisiae Japonicae Herba anti-acute lung injury UPLC–Orbitrap Fusion–MS active compounds ginsenoside Rb1 ginsenoside CK ginsenoside PPD hyperlipidemia gut microbiota bile acid metabolism lignin linkages Klebsiella aerogenes lignocellulose catalytic mechanism Lycium ruthenicum Murray extraction and identification methods bioactivities applied research PLP NADPH 1,4-diaminobutane cofactor synanthropic herbaceous plants endophytic bacteria biologically active compounds biosynthetic gene clusters n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSV Zoology and animal sciences Plants and microorganisms, particularly medicinal herbs, harbor a diverse array of natural products. Many of these are bioactive molecules with potential applications in pharmaceuticals and healthcare. However, the concentrations of these bioactive compounds in plants or microorganisms are usually low. The advancement of omics technologies and synthetic biology has opened up new possibilities for producing these bioactive molecules through the metabolic engineering of plants and microorganisms. Especially substances like artemisinin, rare ginsenosides, and several other natural products have already been successfully manufactured on a large scale. This reprint aims to provide an overview of the current state-of-the-art synthetic biology and engineering biology technologies used in plants and microorganisms for the biosynthesis and scalable production of natural products. 2025-02-20T13:23:28Z 2025-02-20T13:23:28Z 2024 book ONIX_20250220_9783725826063_353 9783725826063 9783725826056 https://directory.doabooks.org/handle/20.500.12854/152989 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/10207 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-2605-6 10.3390/books978-3-7258-2605-6 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725826063 9783725826056 258 Basel open access |
| spellingShingle | Citrus reticulata ‘chachi’ transcriptome metabolome flavonoid Artemisia annua artemisinin synthetic biology genetic engineering transcription factor Ganoderma luteomarginatum lanostane triterpenoids ergostane steroids cytotoxic activity excision wound epithelization essential oils wound healing biological nano selenium nutritional composition antioxidant stress organic selenium ABC transporter family Epimedium flavonoids pharmacological activities extraction methods biotransformation biosynthesis L-cysteine metabolic engineering fermentation fed-batch process downstream processing Ardisiae Japonicae Herba anti-acute lung injury UPLC–Orbitrap Fusion–MS active compounds ginsenoside Rb1 ginsenoside CK ginsenoside PPD hyperlipidemia gut microbiota bile acid metabolism lignin linkages Klebsiella aerogenes lignocellulose catalytic mechanism Lycium ruthenicum Murray extraction and identification methods bioactivities applied research PLP NADPH 1,4-diaminobutane cofactor synanthropic herbaceous plants endophytic bacteria biologically active compounds biosynthetic gene clusters n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSV Zoology and animal sciences Synthesis of Natural Products Using Engineered Plants and Microorganisms |
| title | Synthesis of Natural Products Using Engineered Plants and Microorganisms |
| title_full | Synthesis of Natural Products Using Engineered Plants and Microorganisms |
| title_fullStr | Synthesis of Natural Products Using Engineered Plants and Microorganisms |
| title_full_unstemmed | Synthesis of Natural Products Using Engineered Plants and Microorganisms |
| title_short | Synthesis of Natural Products Using Engineered Plants and Microorganisms |
| title_sort | synthesis of natural products using engineered plants and microorganisms |
| topic | Citrus reticulata ‘chachi’ transcriptome metabolome flavonoid Artemisia annua artemisinin synthetic biology genetic engineering transcription factor Ganoderma luteomarginatum lanostane triterpenoids ergostane steroids cytotoxic activity excision wound epithelization essential oils wound healing biological nano selenium nutritional composition antioxidant stress organic selenium ABC transporter family Epimedium flavonoids pharmacological activities extraction methods biotransformation biosynthesis L-cysteine metabolic engineering fermentation fed-batch process downstream processing Ardisiae Japonicae Herba anti-acute lung injury UPLC–Orbitrap Fusion–MS active compounds ginsenoside Rb1 ginsenoside CK ginsenoside PPD hyperlipidemia gut microbiota bile acid metabolism lignin linkages Klebsiella aerogenes lignocellulose catalytic mechanism Lycium ruthenicum Murray extraction and identification methods bioactivities applied research PLP NADPH 1,4-diaminobutane cofactor synanthropic herbaceous plants endophytic bacteria biologically active compounds biosynthetic gene clusters n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSV Zoology and animal sciences |
| topic_facet | Citrus reticulata ‘chachi’ transcriptome metabolome flavonoid Artemisia annua artemisinin synthetic biology genetic engineering transcription factor Ganoderma luteomarginatum lanostane triterpenoids ergostane steroids cytotoxic activity excision wound epithelization essential oils wound healing biological nano selenium nutritional composition antioxidant stress organic selenium ABC transporter family Epimedium flavonoids pharmacological activities extraction methods biotransformation biosynthesis L-cysteine metabolic engineering fermentation fed-batch process downstream processing Ardisiae Japonicae Herba anti-acute lung injury UPLC–Orbitrap Fusion–MS active compounds ginsenoside Rb1 ginsenoside CK ginsenoside PPD hyperlipidemia gut microbiota bile acid metabolism lignin linkages Klebsiella aerogenes lignocellulose catalytic mechanism Lycium ruthenicum Murray extraction and identification methods bioactivities applied research PLP NADPH 1,4-diaminobutane cofactor synanthropic herbaceous plants endophytic bacteria biologically active compounds biosynthetic gene clusters n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSV Zoology and animal sciences |
| url | ONIX_20250220_9783725826063_353 |