New Diagnostic and Therapeutic Aspects of Thrombotic Thrombocytopenic Purpura
Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening thrombotic microangiopathy caused by congenital or acquired severe deficiency of the von Willebrand factor cleaving protease, ADAMTS13. Acute TTP is a medical emergency requiring a rapid differential diagnosis and immediate tre...
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MDPI - Multidisciplinary Digital Publishing Institute
2025
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| Առցանց հասանելիություն: | ONIX_20250220_9783725828593_467 |
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| description | Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening thrombotic microangiopathy caused by congenital or acquired severe deficiency of the von Willebrand factor cleaving protease, ADAMTS13. Acute TTP is a medical emergency requiring a rapid differential diagnosis and immediate treatment, which is often challenging due to the overlap between clinical and laboratory features and other thrombotic microangiopathies. Diagnostic and therapeutic advancements over the past decade, including the increased availability of ADAMTS13 testing and the development of caplacizumab, the first targeted therapy for acquired TTP, have significantly improved the management of acute TTP and reduced the burden of short-term outcomes such as mortality and exacerbation of acute disease. Concurrently, new clinical challenges have emerged, to mention but one, addressing the burden of long-term complications of TTP and cardiovascular comorbidities in TTP patients in remission. This Special Issue will cover new diagnostic and therapeutic aspects of TTP care, with the scope of advancing our knowledge and clinical intervention to address the current challenges of TTP management. Original, review, and guidance/guideline papers are welcome. |
| format | Online |
| id | doab-20.500.12854ir-153103 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1531032025-02-20T13:33:49Z New Diagnostic and Therapeutic Aspects of Thrombotic Thrombocytopenic Purpura Mancini, Ilaria Artoni, Andrea thrombotic thrombocytopenic purpura (TTP) ADAMTS13 ADAMTS13 testing differential diagnosis of thrombotic microangiopathy disease awareness TTP therapy refractoriness exacerbation thromboembolic complications new therapeutic approaches long-term outcomes TTP relapse prevention pregnancy management management of predisposing conditions/precipitating factors hospital resources thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBP Health systems and services::MBPK Mental health services Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening thrombotic microangiopathy caused by congenital or acquired severe deficiency of the von Willebrand factor cleaving protease, ADAMTS13. Acute TTP is a medical emergency requiring a rapid differential diagnosis and immediate treatment, which is often challenging due to the overlap between clinical and laboratory features and other thrombotic microangiopathies. Diagnostic and therapeutic advancements over the past decade, including the increased availability of ADAMTS13 testing and the development of caplacizumab, the first targeted therapy for acquired TTP, have significantly improved the management of acute TTP and reduced the burden of short-term outcomes such as mortality and exacerbation of acute disease. Concurrently, new clinical challenges have emerged, to mention but one, addressing the burden of long-term complications of TTP and cardiovascular comorbidities in TTP patients in remission. This Special Issue will cover new diagnostic and therapeutic aspects of TTP care, with the scope of advancing our knowledge and clinical intervention to address the current challenges of TTP management. Original, review, and guidance/guideline papers are welcome. 2025-02-20T13:33:46Z 2025-02-20T13:33:46Z 2025 book ONIX_20250220_9783725828593_467 9783725828593 9783725828609 https://directory.doabooks.org/handle/20.500.12854/153103 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/10399 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-2860-9 10.3390/books978-3-7258-2860-9 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725828593 9783725828609 142 Basel open access |
| spellingShingle | thrombotic thrombocytopenic purpura (TTP) ADAMTS13 ADAMTS13 testing differential diagnosis of thrombotic microangiopathy disease awareness TTP therapy refractoriness exacerbation thromboembolic complications new therapeutic approaches long-term outcomes TTP relapse prevention pregnancy management management of predisposing conditions/precipitating factors hospital resources thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBP Health systems and services::MBPK Mental health services New Diagnostic and Therapeutic Aspects of Thrombotic Thrombocytopenic Purpura |
| title | New Diagnostic and Therapeutic Aspects of Thrombotic Thrombocytopenic Purpura |
| title_full | New Diagnostic and Therapeutic Aspects of Thrombotic Thrombocytopenic Purpura |
| title_fullStr | New Diagnostic and Therapeutic Aspects of Thrombotic Thrombocytopenic Purpura |
| title_full_unstemmed | New Diagnostic and Therapeutic Aspects of Thrombotic Thrombocytopenic Purpura |
| title_short | New Diagnostic and Therapeutic Aspects of Thrombotic Thrombocytopenic Purpura |
| title_sort | new diagnostic and therapeutic aspects of thrombotic thrombocytopenic purpura |
| topic | thrombotic thrombocytopenic purpura (TTP) ADAMTS13 ADAMTS13 testing differential diagnosis of thrombotic microangiopathy disease awareness TTP therapy refractoriness exacerbation thromboembolic complications new therapeutic approaches long-term outcomes TTP relapse prevention pregnancy management management of predisposing conditions/precipitating factors hospital resources thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBP Health systems and services::MBPK Mental health services |
| topic_facet | thrombotic thrombocytopenic purpura (TTP) ADAMTS13 ADAMTS13 testing differential diagnosis of thrombotic microangiopathy disease awareness TTP therapy refractoriness exacerbation thromboembolic complications new therapeutic approaches long-term outcomes TTP relapse prevention pregnancy management management of predisposing conditions/precipitating factors hospital resources thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBP Health systems and services::MBPK Mental health services |
| url | ONIX_20250220_9783725828593_467 |