Flipons
Alan Herbert has played a leading part in discovering the biological roles for a high-energy form of DNA twisted to the left rather than to the right. Both Z-DNA and the Z-RNA sensing proteins are critical for protecting hosts against both viruses and cancers. The proteins also play critical roles i...
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Taylor & Francis
2025
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| Online Erişim: | ONIX_20250422_9781040024959_17a |
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| _version_ | 1869520785490575360 |
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| author | Herbert, Alan |
| author_browse | Herbert, Alan |
| author_facet | Herbert, Alan |
| author_sort | Herbert, Alan |
| collection | Directory of Open Access Books |
| description | Alan Herbert has played a leading part in discovering the biological roles for a high-energy form of DNA twisted to the left rather than to the right. Both Z-DNA and the Z-RNA sensing proteins are critical for protecting hosts against both viruses and cancers. The proteins also play critical roles in the programmed cell death of aging cells. Other types of flipons exist and alter the readout of transcripts from the genome, encoding genetic information by their shape rather than by their sequence. Many of these flipons are within repeat elements that were previously considered to be just genomic junk. Instead these genetic elements increase the adaptability of cells by flipping DNA conformation. By acting as digital switches, the different flipon types can alter cellular responses without any change to their sequence or any damage to DNA. These highly dynamic structures enable the rapid evolution of multicellular organisms. The junk DNA in repeats also encode peptide patches that enable the assembly of cellular machines. The intransitive logic involved enhances the chance of an individual surviving a constantly changing environment. Key Features Causes us to rethink how information is encoded in the genome Changes our understanding of how our genome evolved and how we protect ourselves against viruses and cancers while sparing normal cells Shows that high energy forms of DNA, such as left-handed DNA do exist inside the cell Accessible to those in academia and the general public, and speaks to the next generation, encouraging them to find their own path in scientific discovery The Open Access version of this book, available at http://www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non-Commercial-No Derivative License (CC-BY-NC-ND) 4.0 license. |
| format | Online |
| id | doab-20.500.12854ir-158723 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Taylor & Francis |
| publisherStr | Taylor & Francis |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1587232025-04-26T06:19:48Z Flipons Herbert, Alan DNA RNA Translation transcription left-handed z-DNA Flipons Alan Herbert has played a leading part in discovering the biological roles for a high-energy form of DNA twisted to the left rather than to the right. Both Z-DNA and the Z-RNA sensing proteins are critical for protecting hosts against both viruses and cancers. The proteins also play critical roles in the programmed cell death of aging cells. Other types of flipons exist and alter the readout of transcripts from the genome, encoding genetic information by their shape rather than by their sequence. Many of these flipons are within repeat elements that were previously considered to be just genomic junk. Instead these genetic elements increase the adaptability of cells by flipping DNA conformation. By acting as digital switches, the different flipon types can alter cellular responses without any change to their sequence or any damage to DNA. These highly dynamic structures enable the rapid evolution of multicellular organisms. The junk DNA in repeats also encode peptide patches that enable the assembly of cellular machines. The intransitive logic involved enhances the chance of an individual surviving a constantly changing environment. Key Features Causes us to rethink how information is encoded in the genome Changes our understanding of how our genome evolved and how we protect ourselves against viruses and cancers while sparing normal cells Shows that high energy forms of DNA, such as left-handed DNA do exist inside the cell Accessible to those in academia and the general public, and speaks to the next generation, encouraging them to find their own path in scientific discovery The Open Access version of this book, available at http://www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non-Commercial-No Derivative License (CC-BY-NC-ND) 4.0 license. 2025-04-23T06:43:31Z 2025-04-23T06:43:31Z 2025-04-22T11:38:19Z 2024 book ONIX_20250422_9781040024959_17a https://library.oapen.org/handle/20.500.12657/101023 9781040024959 9781003463535 9781032732961 9781040025000 9781032731087 https://directory.doabooks.org/handle/20.500.12854/158723 eng open access image/jpeg Attribution-NonCommercial-NoDerivatives 4.0 International https://library.oapen.org/bitstream/20.500.12657/101023/1/9781040024959.pdf Taylor & Francis CRC Press 10.1201/9781003463535 10.1201/9781003463535 fa69b019-f4ee-4979-8d42-c6b6c476b5f0 9781040024959 9781003463535 9781032732961 9781040025000 9781032731087 CRC Press 227 open access |
| spellingShingle | DNA RNA Translation transcription left-handed z-DNA Flipons Herbert, Alan Flipons |
| title | Flipons |
| title_full | Flipons |
| title_fullStr | Flipons |
| title_full_unstemmed | Flipons |
| title_short | Flipons |
| title_sort | flipons |
| topic | DNA RNA Translation transcription left-handed z-DNA Flipons |
| topic_facet | DNA RNA Translation transcription left-handed z-DNA Flipons |
| url | ONIX_20250422_9781040024959_17a |
| work_keys_str_mv | AT herbertalan flipons |