Oral Cancer
Oral cancer contributes to approximately 3–10% of all cancer mortality worldwide, and its incidence is continuously increasing due to environmental conditions and harmful modern lifestyles. In association with hereditary predisposition, chronic inflammation, and infectious diseases, these factors ra...
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| Aineistotyyppi: | Online |
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| Kieli: | englanti |
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MDPI - Multidisciplinary Digital Publishing Institute
2025
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| Linkit: | ONIX_20250812T095121_9783725830152_25 |
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| _version_ | 1869526044905570304 |
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| collection | Directory of Open Access Books |
| description | Oral cancer contributes to approximately 3–10% of all cancer mortality worldwide, and its incidence is continuously increasing due to environmental conditions and harmful modern lifestyles. In association with hereditary predisposition, chronic inflammation, and infectious diseases, these factors raise the frequency of oral cavity malignancies. Oral squamous cell carcinoma (OSCC) represents 90% of oral neoplasia; it is the sixth most frequent malignancy in the world, with an overall 5-year survival rate below 50% due to its modest outcomes, late diagnosis, aggressive local invasiveness, recurrences, and metastases. OSCC belongs to the comprehensive group of head and neck squamous cell carcinomas (HNSCCs), which affect the cell lining of the oral cavity, pharynx, and larynx. The local–regional recurrence rate for advanced carcinomas is over 50% despite the administration of multimodal therapy, and understanding the biology of HNSCCs is essential to ameliorate their prognosis. A major intervention involves extensive surgery associated with radio and chemotherapy. Advancements in cancer immunotherapy have not yet established the specific mechanisms by which immune cells influence tumor progression and immune evasion, and oral cancers continue to respond inadequately to the current treatment protocols. The above-mentioned aspects underline this Special Issue, which has brought together the most recent research on molecular mechanisms implied in the prophylaxis, etiopathogenesis, diagnosis, treatment, evolution, and prognosis of oral cancer. |
| format | Online |
| id | doab-20.500.12854ir-165076 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1650762025-08-12T07:59:26Z Oral Cancer Popovici, Violeta Ozon, Emma Adriana OSCC M2 macrophages exosome MiR-23a-3p PTEN CD44 CD44v10 monoclonal antibody oral squamous cell carcinoma immunohistochemistry oropharyngeal squamous cell carcinoma (OPSCC) mutation MUC6 MUC16 p62 OPMDs XPO1 ki67 p53 cancer development head and neck squamous cell carcinoma (HNSCC) therapeutic cancer vaccine Epstein–Barr virus (EBV) human papilloma virus (HPV) mRNA vaccine Wnt signaling the Warburg effect aerobic glycolysis head and neck cancer tongue cancer PRI-724 IWP-O1 β-catenin pyruvate kinase lactate dehydrogenase EGFR COX-2 histological grade canine calcitriol oral cancer oral dysplasia head and neck squamous-cell carcinoma tissue engineering oral mucosa 3D tissue model microRNA diagnosis biomarker n/a HNSCC carcinogenesis protein level tumor surgical margin CDKN2A Ki-67 thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Oral cancer contributes to approximately 3–10% of all cancer mortality worldwide, and its incidence is continuously increasing due to environmental conditions and harmful modern lifestyles. In association with hereditary predisposition, chronic inflammation, and infectious diseases, these factors raise the frequency of oral cavity malignancies. Oral squamous cell carcinoma (OSCC) represents 90% of oral neoplasia; it is the sixth most frequent malignancy in the world, with an overall 5-year survival rate below 50% due to its modest outcomes, late diagnosis, aggressive local invasiveness, recurrences, and metastases. OSCC belongs to the comprehensive group of head and neck squamous cell carcinomas (HNSCCs), which affect the cell lining of the oral cavity, pharynx, and larynx. The local–regional recurrence rate for advanced carcinomas is over 50% despite the administration of multimodal therapy, and understanding the biology of HNSCCs is essential to ameliorate their prognosis. A major intervention involves extensive surgery associated with radio and chemotherapy. Advancements in cancer immunotherapy have not yet established the specific mechanisms by which immune cells influence tumor progression and immune evasion, and oral cancers continue to respond inadequately to the current treatment protocols. The above-mentioned aspects underline this Special Issue, which has brought together the most recent research on molecular mechanisms implied in the prophylaxis, etiopathogenesis, diagnosis, treatment, evolution, and prognosis of oral cancer. 2025-08-12T07:59:24Z 2025-08-12T07:59:24Z 2025 book ONIX_20250812T095121_9783725830152_25 9783725830152 9783725830169 https://directory.doabooks.org/handle/20.500.12854/165076 eng image/jpeg Attribution 4.0 International https://mdpi.com/books https://mdpi.com/books/pdfview/book/10498 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-3016-9 10.3390/books978-3-7258-3016-9 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725830152 9783725830169 166 open access |
| spellingShingle | OSCC M2 macrophages exosome MiR-23a-3p PTEN CD44 CD44v10 monoclonal antibody oral squamous cell carcinoma immunohistochemistry oropharyngeal squamous cell carcinoma (OPSCC) mutation MUC6 MUC16 p62 OPMDs XPO1 ki67 p53 cancer development head and neck squamous cell carcinoma (HNSCC) therapeutic cancer vaccine Epstein–Barr virus (EBV) human papilloma virus (HPV) mRNA vaccine Wnt signaling the Warburg effect aerobic glycolysis head and neck cancer tongue cancer PRI-724 IWP-O1 β-catenin pyruvate kinase lactate dehydrogenase EGFR COX-2 histological grade canine calcitriol oral cancer oral dysplasia head and neck squamous-cell carcinoma tissue engineering oral mucosa 3D tissue model microRNA diagnosis biomarker n/a HNSCC carcinogenesis protein level tumor surgical margin CDKN2A Ki-67 thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Oral Cancer |
| title | Oral Cancer |
| title_full | Oral Cancer |
| title_fullStr | Oral Cancer |
| title_full_unstemmed | Oral Cancer |
| title_short | Oral Cancer |
| title_sort | oral cancer |
| topic | OSCC M2 macrophages exosome MiR-23a-3p PTEN CD44 CD44v10 monoclonal antibody oral squamous cell carcinoma immunohistochemistry oropharyngeal squamous cell carcinoma (OPSCC) mutation MUC6 MUC16 p62 OPMDs XPO1 ki67 p53 cancer development head and neck squamous cell carcinoma (HNSCC) therapeutic cancer vaccine Epstein–Barr virus (EBV) human papilloma virus (HPV) mRNA vaccine Wnt signaling the Warburg effect aerobic glycolysis head and neck cancer tongue cancer PRI-724 IWP-O1 β-catenin pyruvate kinase lactate dehydrogenase EGFR COX-2 histological grade canine calcitriol oral cancer oral dysplasia head and neck squamous-cell carcinoma tissue engineering oral mucosa 3D tissue model microRNA diagnosis biomarker n/a HNSCC carcinogenesis protein level tumor surgical margin CDKN2A Ki-67 thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | OSCC M2 macrophages exosome MiR-23a-3p PTEN CD44 CD44v10 monoclonal antibody oral squamous cell carcinoma immunohistochemistry oropharyngeal squamous cell carcinoma (OPSCC) mutation MUC6 MUC16 p62 OPMDs XPO1 ki67 p53 cancer development head and neck squamous cell carcinoma (HNSCC) therapeutic cancer vaccine Epstein–Barr virus (EBV) human papilloma virus (HPV) mRNA vaccine Wnt signaling the Warburg effect aerobic glycolysis head and neck cancer tongue cancer PRI-724 IWP-O1 β-catenin pyruvate kinase lactate dehydrogenase EGFR COX-2 histological grade canine calcitriol oral cancer oral dysplasia head and neck squamous-cell carcinoma tissue engineering oral mucosa 3D tissue model microRNA diagnosis biomarker n/a HNSCC carcinogenesis protein level tumor surgical margin CDKN2A Ki-67 thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20250812T095121_9783725830152_25 |