Aggregatibacter actinomycetemcomitans
This reprint is devoted to the oral microbe Aggregatibacter actinomycetemcomitans and its associated distinctive form of rapidly destructive periodontitis that results in early tooth loss, predominantly occurring in adolescents and children of African descent. Three chapters are related to the biolo...
Wedi'i Gadw mewn:
| Fformat: | Online |
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| Iaith: | Saesneg |
| Cyhoeddwyd: |
MDPI - Multidisciplinary Digital Publishing Institute
2025
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| Pynciau: | |
| Mynediad Ar-lein: | ONIX_20250812T095121_9783725830633_32 |
| Tagiau: |
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!
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| _version_ | 1869519606494789632 |
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| collection | Directory of Open Access Books |
| description | This reprint is devoted to the oral microbe Aggregatibacter actinomycetemcomitans and its associated distinctive form of rapidly destructive periodontitis that results in early tooth loss, predominantly occurring in adolescents and children of African descent. Three chapters are related to the biological and clinical characteristics of the disease, while six chapters are devoted genetic features uniquely suited for local disruption of the host’s homeostatic balance. The final two chapters illustrate how a deep molecular understanding of A. actinomycetemcomitans has been used to develop therapies for diseases such as staphylococcal infections and leukemias. The reprint illustrates A. actinomycetemcomitans’s 1) highly adaptable nature, 2) its influence on its microbial cohorts, 3) its modulation of local host responsiveness, and 4) its relationship to tissue damage, microbial survival tactics, and metabolic and competitive ecological strategies. These microbe-related processes can be applied to other infectious diseases. The Damage–Response Framework is illustrated as the most appropriate way to consider this microbe, its effect on its host, and the relationship of time to the extent of damage or repair. |
| format | Online |
| id | doab-20.500.12854ir-165083 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1650832025-08-12T08:00:05Z Aggregatibacter actinomycetemcomitans Fine, Daniel H. bacterial adhesin collagen interactions electron tomography 3D structure biofilm Aggregatibacter actinomycetemcomitans cytolethal distending toxin senescence oral keratinocytes cellugyrin synaptogyrin-2 periodontal disease LFA-1 inflammation leukemia lymphoma autoimmune disease translational research drug development protein drug allergic asthma inflammatory bowel disease Crohn’s disease ulcerative colitis salivary concentrations rheumatoid arthritis systemic biomarker dormancy stress response bacterial physiology leukotoxin release JP2-genotype culture conditions periodontitis aggressive immunological factors microbiota genetics biofilm matrix biomaterial coating DspB EPS exopolysaccharide extracellular DNA eDNA matrix-degrading enzyme PIA PNAG Staphylococcus aureus Staphylococcus epidermidis aggressive periodontitis Porphyromonas gingivalis biogeography biofilms Localized Stage III Grade C periodontitis treatment success consensus conferences microbiome consortia damage/response framework complement resistance factor H epithelial cell binding auto-aggregation global regulation n/a thema EDItEUR::M Medicine and Nursing This reprint is devoted to the oral microbe Aggregatibacter actinomycetemcomitans and its associated distinctive form of rapidly destructive periodontitis that results in early tooth loss, predominantly occurring in adolescents and children of African descent. Three chapters are related to the biological and clinical characteristics of the disease, while six chapters are devoted genetic features uniquely suited for local disruption of the host’s homeostatic balance. The final two chapters illustrate how a deep molecular understanding of A. actinomycetemcomitans has been used to develop therapies for diseases such as staphylococcal infections and leukemias. The reprint illustrates A. actinomycetemcomitans’s 1) highly adaptable nature, 2) its influence on its microbial cohorts, 3) its modulation of local host responsiveness, and 4) its relationship to tissue damage, microbial survival tactics, and metabolic and competitive ecological strategies. These microbe-related processes can be applied to other infectious diseases. The Damage–Response Framework is illustrated as the most appropriate way to consider this microbe, its effect on its host, and the relationship of time to the extent of damage or repair. 2025-08-12T08:00:02Z 2025-08-12T08:00:02Z 2025 book ONIX_20250812T095121_9783725830633_32 9783725830633 9783725830640 https://directory.doabooks.org/handle/20.500.12854/165083 eng image/jpeg Attribution 4.0 International https://mdpi.com/books https://mdpi.com/books/pdfview/book/10521 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-3064-0 10.3390/books978-3-7258-3064-0 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725830633 9783725830640 214 open access |
| spellingShingle | bacterial adhesin collagen interactions electron tomography 3D structure biofilm Aggregatibacter actinomycetemcomitans cytolethal distending toxin senescence oral keratinocytes cellugyrin synaptogyrin-2 periodontal disease LFA-1 inflammation leukemia lymphoma autoimmune disease translational research drug development protein drug allergic asthma inflammatory bowel disease Crohn’s disease ulcerative colitis salivary concentrations rheumatoid arthritis systemic biomarker dormancy stress response bacterial physiology leukotoxin release JP2-genotype culture conditions periodontitis aggressive immunological factors microbiota genetics biofilm matrix biomaterial coating DspB EPS exopolysaccharide extracellular DNA eDNA matrix-degrading enzyme PIA PNAG Staphylococcus aureus Staphylococcus epidermidis aggressive periodontitis Porphyromonas gingivalis biogeography biofilms Localized Stage III Grade C periodontitis treatment success consensus conferences microbiome consortia damage/response framework complement resistance factor H epithelial cell binding auto-aggregation global regulation n/a thema EDItEUR::M Medicine and Nursing Aggregatibacter actinomycetemcomitans |
| title | Aggregatibacter actinomycetemcomitans |
| title_full | Aggregatibacter actinomycetemcomitans |
| title_fullStr | Aggregatibacter actinomycetemcomitans |
| title_full_unstemmed | Aggregatibacter actinomycetemcomitans |
| title_short | Aggregatibacter actinomycetemcomitans |
| title_sort | aggregatibacter actinomycetemcomitans |
| topic | bacterial adhesin collagen interactions electron tomography 3D structure biofilm Aggregatibacter actinomycetemcomitans cytolethal distending toxin senescence oral keratinocytes cellugyrin synaptogyrin-2 periodontal disease LFA-1 inflammation leukemia lymphoma autoimmune disease translational research drug development protein drug allergic asthma inflammatory bowel disease Crohn’s disease ulcerative colitis salivary concentrations rheumatoid arthritis systemic biomarker dormancy stress response bacterial physiology leukotoxin release JP2-genotype culture conditions periodontitis aggressive immunological factors microbiota genetics biofilm matrix biomaterial coating DspB EPS exopolysaccharide extracellular DNA eDNA matrix-degrading enzyme PIA PNAG Staphylococcus aureus Staphylococcus epidermidis aggressive periodontitis Porphyromonas gingivalis biogeography biofilms Localized Stage III Grade C periodontitis treatment success consensus conferences microbiome consortia damage/response framework complement resistance factor H epithelial cell binding auto-aggregation global regulation n/a thema EDItEUR::M Medicine and Nursing |
| topic_facet | bacterial adhesin collagen interactions electron tomography 3D structure biofilm Aggregatibacter actinomycetemcomitans cytolethal distending toxin senescence oral keratinocytes cellugyrin synaptogyrin-2 periodontal disease LFA-1 inflammation leukemia lymphoma autoimmune disease translational research drug development protein drug allergic asthma inflammatory bowel disease Crohn’s disease ulcerative colitis salivary concentrations rheumatoid arthritis systemic biomarker dormancy stress response bacterial physiology leukotoxin release JP2-genotype culture conditions periodontitis aggressive immunological factors microbiota genetics biofilm matrix biomaterial coating DspB EPS exopolysaccharide extracellular DNA eDNA matrix-degrading enzyme PIA PNAG Staphylococcus aureus Staphylococcus epidermidis aggressive periodontitis Porphyromonas gingivalis biogeography biofilms Localized Stage III Grade C periodontitis treatment success consensus conferences microbiome consortia damage/response framework complement resistance factor H epithelial cell binding auto-aggregation global regulation n/a thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20250812T095121_9783725830633_32 |