Effects of Ionizing Radiation in Cancer Radiotherapy
For a long time, it was widely accepted that the biological effects of ionizing radiation such as cell death, DNA damage, and mutagenesis result from the direct ionization of cell structures, particularly DNA, or from indirect damage through reactive oxygen species produced by water radiolysis. This...
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MDPI - Multidisciplinary Digital Publishing Institute
2025
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| Mynediad Ar-lein: | ONIX_20250812T095121_9783725833863_185 |
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| collection | Directory of Open Access Books |
| description | For a long time, it was widely accepted that the biological effects of ionizing radiation such as cell death, DNA damage, and mutagenesis result from the direct ionization of cell structures, particularly DNA, or from indirect damage through reactive oxygen species produced by water radiolysis. This “targeted effect” (TE) model has been questioned by numerous observations, in which cells, that were not directly irradiated, exhibited responses similar to those of directly irradiated cells. Therefore, it is now accepted that the detrimental effects of ionizing radiation are not restricted only to irradiated cells, but also to non-irradiated adjacent or distant cells. The non-targeted effects (NTEs) of ionizing radiation, which include genomic instability, radiation-induced bystander effects, and abscopal effects, are defined as the occurrence of biological effects in non-irradiated cells because of the irradiation of other cells in the population. In opposition with TE, that display a linear dose–response, NTEs exhibit a non-linear dose–response, with a marked effect at low doses of radiation. The related cellular and molecular mechanisms of NTEs are still not completely understood, as they are mainly dependent on the cell type and the radiation quality. I am pleased to share with you this Special Issue on the "Targeted and non-targeted effects of ionizing radiation in the context of cancer radiotherapy". |
| format | Online |
| id | doab-20.500.12854ir-165236 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1652362025-08-12T08:15:20Z Effects of Ionizing Radiation in Cancer Radiotherapy Chevalier, François chondrosarcoma bystander signaling proteomic analysis secretome stress granules bystander effect exosomes ionizing radiation non-targeted effects of radiation replication stress radioresistance radiosensitivity cancer stem cells epithelial mesenchymal transition polyploid/multinucleated giant cancer cells proton therapy beam clustered DNA damage linear energy transfer (LET) Agarose Gel Electrophoresis (AGE) Atomic Force Microscopy (AFM) damage biomarkers scavenging capacity biodosimetry glioblastoma multiforme multinucleated giant cancer cell senescent tumor cells (STC) stress-induced premature senescence (SIPS) senescence-associated secretory phenotype (SASP) non-small cell lung cancer DNA repair transcriptomics gene expression cytogenetic biodosimetry radioprotection telomere centromere chromosomal instability radiotherapy radiation-induced BCC low-dose effects ATM-NF-kb signaling PINK1 gene microRNA biomarkers proton radiotherapy pediatric oncology HARMONIC project congenital heart disease cardiac catheterization radiation biomarkers bone marrow ionising radiation extracellular vesicles miRNA content proteome pathway analysis bystander effects thema EDItEUR::M Medicine and Nursing For a long time, it was widely accepted that the biological effects of ionizing radiation such as cell death, DNA damage, and mutagenesis result from the direct ionization of cell structures, particularly DNA, or from indirect damage through reactive oxygen species produced by water radiolysis. This “targeted effect” (TE) model has been questioned by numerous observations, in which cells, that were not directly irradiated, exhibited responses similar to those of directly irradiated cells. Therefore, it is now accepted that the detrimental effects of ionizing radiation are not restricted only to irradiated cells, but also to non-irradiated adjacent or distant cells. The non-targeted effects (NTEs) of ionizing radiation, which include genomic instability, radiation-induced bystander effects, and abscopal effects, are defined as the occurrence of biological effects in non-irradiated cells because of the irradiation of other cells in the population. In opposition with TE, that display a linear dose–response, NTEs exhibit a non-linear dose–response, with a marked effect at low doses of radiation. The related cellular and molecular mechanisms of NTEs are still not completely understood, as they are mainly dependent on the cell type and the radiation quality. I am pleased to share with you this Special Issue on the "Targeted and non-targeted effects of ionizing radiation in the context of cancer radiotherapy". 2025-08-12T08:15:18Z 2025-08-12T08:15:18Z 2025 book ONIX_20250812T095121_9783725833863_185 9783725833863 9783725833856 https://directory.doabooks.org/handle/20.500.12854/165236 eng image/jpeg Attribution 4.0 International https://mdpi.com/books https://mdpi.com/books/pdfview/book/10643 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-3385-6 10.3390/books978-3-7258-3385-6 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725833863 9783725833856 214 open access |
| spellingShingle | chondrosarcoma bystander signaling proteomic analysis secretome stress granules bystander effect exosomes ionizing radiation non-targeted effects of radiation replication stress radioresistance radiosensitivity cancer stem cells epithelial mesenchymal transition polyploid/multinucleated giant cancer cells proton therapy beam clustered DNA damage linear energy transfer (LET) Agarose Gel Electrophoresis (AGE) Atomic Force Microscopy (AFM) damage biomarkers scavenging capacity biodosimetry glioblastoma multiforme multinucleated giant cancer cell senescent tumor cells (STC) stress-induced premature senescence (SIPS) senescence-associated secretory phenotype (SASP) non-small cell lung cancer DNA repair transcriptomics gene expression cytogenetic biodosimetry radioprotection telomere centromere chromosomal instability radiotherapy radiation-induced BCC low-dose effects ATM-NF-kb signaling PINK1 gene microRNA biomarkers proton radiotherapy pediatric oncology HARMONIC project congenital heart disease cardiac catheterization radiation biomarkers bone marrow ionising radiation extracellular vesicles miRNA content proteome pathway analysis bystander effects thema EDItEUR::M Medicine and Nursing Effects of Ionizing Radiation in Cancer Radiotherapy |
| title | Effects of Ionizing Radiation in Cancer Radiotherapy |
| title_full | Effects of Ionizing Radiation in Cancer Radiotherapy |
| title_fullStr | Effects of Ionizing Radiation in Cancer Radiotherapy |
| title_full_unstemmed | Effects of Ionizing Radiation in Cancer Radiotherapy |
| title_short | Effects of Ionizing Radiation in Cancer Radiotherapy |
| title_sort | effects of ionizing radiation in cancer radiotherapy |
| topic | chondrosarcoma bystander signaling proteomic analysis secretome stress granules bystander effect exosomes ionizing radiation non-targeted effects of radiation replication stress radioresistance radiosensitivity cancer stem cells epithelial mesenchymal transition polyploid/multinucleated giant cancer cells proton therapy beam clustered DNA damage linear energy transfer (LET) Agarose Gel Electrophoresis (AGE) Atomic Force Microscopy (AFM) damage biomarkers scavenging capacity biodosimetry glioblastoma multiforme multinucleated giant cancer cell senescent tumor cells (STC) stress-induced premature senescence (SIPS) senescence-associated secretory phenotype (SASP) non-small cell lung cancer DNA repair transcriptomics gene expression cytogenetic biodosimetry radioprotection telomere centromere chromosomal instability radiotherapy radiation-induced BCC low-dose effects ATM-NF-kb signaling PINK1 gene microRNA biomarkers proton radiotherapy pediatric oncology HARMONIC project congenital heart disease cardiac catheterization radiation biomarkers bone marrow ionising radiation extracellular vesicles miRNA content proteome pathway analysis bystander effects thema EDItEUR::M Medicine and Nursing |
| topic_facet | chondrosarcoma bystander signaling proteomic analysis secretome stress granules bystander effect exosomes ionizing radiation non-targeted effects of radiation replication stress radioresistance radiosensitivity cancer stem cells epithelial mesenchymal transition polyploid/multinucleated giant cancer cells proton therapy beam clustered DNA damage linear energy transfer (LET) Agarose Gel Electrophoresis (AGE) Atomic Force Microscopy (AFM) damage biomarkers scavenging capacity biodosimetry glioblastoma multiforme multinucleated giant cancer cell senescent tumor cells (STC) stress-induced premature senescence (SIPS) senescence-associated secretory phenotype (SASP) non-small cell lung cancer DNA repair transcriptomics gene expression cytogenetic biodosimetry radioprotection telomere centromere chromosomal instability radiotherapy radiation-induced BCC low-dose effects ATM-NF-kb signaling PINK1 gene microRNA biomarkers proton radiotherapy pediatric oncology HARMONIC project congenital heart disease cardiac catheterization radiation biomarkers bone marrow ionising radiation extracellular vesicles miRNA content proteome pathway analysis bystander effects thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20250812T095121_9783725833863_185 |