Brain Injury and Neurodegeneration
The brain encompasses numerous kind of cells, such as, neurons, astrocytes, microglia, oligodendrocytes, pericytes, and endothelial cells, etc., which have specific structures and functions, as well as an integrated role in CNS homeostasis. For example, glial cells—especially astrocytes and microgli...
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| Idioma: | anglès |
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MDPI - Multidisciplinary Digital Publishing Institute
2025
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| Accés en línia: | ONIX_20250812T110751_9783725834570_24 |
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| description | The brain encompasses numerous kind of cells, such as, neurons, astrocytes, microglia, oligodendrocytes, pericytes, and endothelial cells, etc., which have specific structures and functions, as well as an integrated role in CNS homeostasis. For example, glial cells—especially astrocytes and microglia—respond to immunological clues, secrete chemokines/cytokines/growth factors, perform phagocytosis, and support the neurons and vasculature of the CNS. Any insult to the brain, such as in the case of a traumatic brain injury, causes neuroinflammation that leads to chronic traumatic encephalopathy (CTE) and other neurodegenerative diseases. Environmental and occupational factors, such as blast, can also cause neuroinflammation and cognitive impairment. Addiction to alcohol and tobacco or hormones can afflict brain health in many ways. In addition, the health of other organs such as oral health and microbiota has a great impact on neurological and cardiovascular health, and has garnered much attention recently. With rapid advances in neuroimaging, improved diagnostic tools, and the identification of biomarkers, we have improved our understanding of brain pathologies and their chronic impact. This Special Issue is the second in the series on the topic and has brought together interesting research on cellular functions, environmental impacts, and therapeutic interventions for brain pathologies, providing a comprehensive overview of the current progress in neuroscience. With a compilation of 16 articles, this Special Issue will be a fascinating read for the readers. |
| format | Online |
| id | doab-20.500.12854ir-165268 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1652682025-08-12T09:15:45Z Brain Injury and Neurodegeneration Vaibhav, Kumar Ahluwalia, Pankaj Gaur, Pankaj Ahluwalia, Meenakshi repetitive low-level blast experienced breacher traumatic brain injury NLRP3 inflammasome MCC950 rt-PA blood–brain barrier Cell Index ASC ischemic stroke i.v. thrombolysis vascular basement membrane collagen-IV laminin-111 fibronectin substantia nigra alcoholism light microscopy electron microscopy hippocampus brain trauma glucocorticoids corticosterone cortisol stress neuroinflammation neurodegeneration remote damage astrocytes reactive astrogliosis TGF-β stroke aging Alzheimer’s disease Parkinson’s disease amyotrophic lateral sclerosis multiple sclerosis epilepsy oral microbiota gut microbiota caries periodontal disease dysbiosis cardiovascular disease Acquired Brain Injury (ABI) post-birth brain impairment brain functions pathologies cellular mechanisms therapeutic approach dipping inflammation eicosanoids leukotriene saturated fatty acids amyloid precursor protein photothrombotic stroke ischemia alpha-secretase beta-secretase gamma-secretase caveolin-1 apoptosis astrocyte activation hypoxia postnatal asphyxia motor cortex synaptic transmission adenosine adenosine A1 receptor nitric oxide cGMP infant rat neuroprotection waterpipe smoking cerebellum oxidative stress DNA damage common carotid artery occlusion corticospinal tract function motor evoked potentials temperature rat psychiatric symptoms severe traumatic brain injury neuropsychiatric disorders behavior mTBI organophosphates cognitive and behavioral tests neuronal loss neuropsychology disorder of consciousness cognitive assessment n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences The brain encompasses numerous kind of cells, such as, neurons, astrocytes, microglia, oligodendrocytes, pericytes, and endothelial cells, etc., which have specific structures and functions, as well as an integrated role in CNS homeostasis. For example, glial cells—especially astrocytes and microglia—respond to immunological clues, secrete chemokines/cytokines/growth factors, perform phagocytosis, and support the neurons and vasculature of the CNS. Any insult to the brain, such as in the case of a traumatic brain injury, causes neuroinflammation that leads to chronic traumatic encephalopathy (CTE) and other neurodegenerative diseases. Environmental and occupational factors, such as blast, can also cause neuroinflammation and cognitive impairment. Addiction to alcohol and tobacco or hormones can afflict brain health in many ways. In addition, the health of other organs such as oral health and microbiota has a great impact on neurological and cardiovascular health, and has garnered much attention recently. With rapid advances in neuroimaging, improved diagnostic tools, and the identification of biomarkers, we have improved our understanding of brain pathologies and their chronic impact. This Special Issue is the second in the series on the topic and has brought together interesting research on cellular functions, environmental impacts, and therapeutic interventions for brain pathologies, providing a comprehensive overview of the current progress in neuroscience. With a compilation of 16 articles, this Special Issue will be a fascinating read for the readers. 2025-08-12T09:15:43Z 2025-08-12T09:15:43Z 2025 book ONIX_20250812T110751_9783725834570_24 9783725834570 9783725834587 https://directory.doabooks.org/handle/20.500.12854/165268 eng image/jpeg Attribution 4.0 International https://mdpi.com/books https://mdpi.com/books/pdfview/book/10624 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-3458-7 10.3390/books978-3-7258-3458-7 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725834570 9783725834587 308 open access |
| spellingShingle | repetitive low-level blast experienced breacher traumatic brain injury NLRP3 inflammasome MCC950 rt-PA blood–brain barrier Cell Index ASC ischemic stroke i.v. thrombolysis vascular basement membrane collagen-IV laminin-111 fibronectin substantia nigra alcoholism light microscopy electron microscopy hippocampus brain trauma glucocorticoids corticosterone cortisol stress neuroinflammation neurodegeneration remote damage astrocytes reactive astrogliosis TGF-β stroke aging Alzheimer’s disease Parkinson’s disease amyotrophic lateral sclerosis multiple sclerosis epilepsy oral microbiota gut microbiota caries periodontal disease dysbiosis cardiovascular disease Acquired Brain Injury (ABI) post-birth brain impairment brain functions pathologies cellular mechanisms therapeutic approach dipping inflammation eicosanoids leukotriene saturated fatty acids amyloid precursor protein photothrombotic stroke ischemia alpha-secretase beta-secretase gamma-secretase caveolin-1 apoptosis astrocyte activation hypoxia postnatal asphyxia motor cortex synaptic transmission adenosine adenosine A1 receptor nitric oxide cGMP infant rat neuroprotection waterpipe smoking cerebellum oxidative stress DNA damage common carotid artery occlusion corticospinal tract function motor evoked potentials temperature rat psychiatric symptoms severe traumatic brain injury neuropsychiatric disorders behavior mTBI organophosphates cognitive and behavioral tests neuronal loss neuropsychology disorder of consciousness cognitive assessment n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Brain Injury and Neurodegeneration |
| title | Brain Injury and Neurodegeneration |
| title_full | Brain Injury and Neurodegeneration |
| title_fullStr | Brain Injury and Neurodegeneration |
| title_full_unstemmed | Brain Injury and Neurodegeneration |
| title_short | Brain Injury and Neurodegeneration |
| title_sort | brain injury and neurodegeneration |
| topic | repetitive low-level blast experienced breacher traumatic brain injury NLRP3 inflammasome MCC950 rt-PA blood–brain barrier Cell Index ASC ischemic stroke i.v. thrombolysis vascular basement membrane collagen-IV laminin-111 fibronectin substantia nigra alcoholism light microscopy electron microscopy hippocampus brain trauma glucocorticoids corticosterone cortisol stress neuroinflammation neurodegeneration remote damage astrocytes reactive astrogliosis TGF-β stroke aging Alzheimer’s disease Parkinson’s disease amyotrophic lateral sclerosis multiple sclerosis epilepsy oral microbiota gut microbiota caries periodontal disease dysbiosis cardiovascular disease Acquired Brain Injury (ABI) post-birth brain impairment brain functions pathologies cellular mechanisms therapeutic approach dipping inflammation eicosanoids leukotriene saturated fatty acids amyloid precursor protein photothrombotic stroke ischemia alpha-secretase beta-secretase gamma-secretase caveolin-1 apoptosis astrocyte activation hypoxia postnatal asphyxia motor cortex synaptic transmission adenosine adenosine A1 receptor nitric oxide cGMP infant rat neuroprotection waterpipe smoking cerebellum oxidative stress DNA damage common carotid artery occlusion corticospinal tract function motor evoked potentials temperature rat psychiatric symptoms severe traumatic brain injury neuropsychiatric disorders behavior mTBI organophosphates cognitive and behavioral tests neuronal loss neuropsychology disorder of consciousness cognitive assessment n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | repetitive low-level blast experienced breacher traumatic brain injury NLRP3 inflammasome MCC950 rt-PA blood–brain barrier Cell Index ASC ischemic stroke i.v. thrombolysis vascular basement membrane collagen-IV laminin-111 fibronectin substantia nigra alcoholism light microscopy electron microscopy hippocampus brain trauma glucocorticoids corticosterone cortisol stress neuroinflammation neurodegeneration remote damage astrocytes reactive astrogliosis TGF-β stroke aging Alzheimer’s disease Parkinson’s disease amyotrophic lateral sclerosis multiple sclerosis epilepsy oral microbiota gut microbiota caries periodontal disease dysbiosis cardiovascular disease Acquired Brain Injury (ABI) post-birth brain impairment brain functions pathologies cellular mechanisms therapeutic approach dipping inflammation eicosanoids leukotriene saturated fatty acids amyloid precursor protein photothrombotic stroke ischemia alpha-secretase beta-secretase gamma-secretase caveolin-1 apoptosis astrocyte activation hypoxia postnatal asphyxia motor cortex synaptic transmission adenosine adenosine A1 receptor nitric oxide cGMP infant rat neuroprotection waterpipe smoking cerebellum oxidative stress DNA damage common carotid artery occlusion corticospinal tract function motor evoked potentials temperature rat psychiatric symptoms severe traumatic brain injury neuropsychiatric disorders behavior mTBI organophosphates cognitive and behavioral tests neuronal loss neuropsychology disorder of consciousness cognitive assessment n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | ONIX_20250812T110751_9783725834570_24 |