Emergence and Control of African Swine Fever
African swine fever (ASF) is a highly lethal and contagious viral disease found in domestic pigs, wild boars, and wild suids, and it has significant economic consequences. This disease is currently endemic in many parts of the world, but the lack of an effective commercial vaccine for prevention and...
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| Ngôn ngữ: | Tiếng Anh |
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MDPI - Multidisciplinary Digital Publishing Institute
2025
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| Truy cập trực tuyến: | ONIX_20250812T110751_9783725840380_302 |
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| collection | Directory of Open Access Books |
| description | African swine fever (ASF) is a highly lethal and contagious viral disease found in domestic pigs, wild boars, and wild suids, and it has significant economic consequences. This disease is currently endemic in many parts of the world, but the lack of an effective commercial vaccine for prevention and control makes the threat of ASF spreading to ASF-free regions more prominent. Currently, the emergence of a new highly lethal genotype I and II recombinant African swine fever viruses disrupted the ability of available vaccine candidates against genotype II in order to protect pigs against ASF. The emergence of this recombinant virus is an example of the complex dynamics that involve the natural infectious cycle of this pathogen. Currently, more research studies are needed to improve the control of ASF. These collections of studies include the areas of control (vaccination, drugs, disinfectants, and immunology), epidemiology, pathogenesis, and diagnostics. The studies compiled in this Reprint contribute to improving the knowledge of several critical aspects of this complex disease. I encourage the scientific community of ASFV to review these published studies. |
| format | Online |
| id | doab-20.500.12854ir-165547 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1655472025-08-12T09:54:02Z Emergence and Control of African Swine Fever Velazquez-Salinas, Lauro Medina, Gisselle N. Ramirez-Medina, Elizabeth African swine fever virus central variable region single-nucleotide polymorphism phylogenetic analysis ASFV ASF virus neutralizing antibodies protective immunity pathology Germany virus variant wild boar natural infection African swine fever virus (ASFV) RNA-seq innate immunity inflammation NF-κB signaling pathway epidemiology prevalence wild boar population density spread control measures clinical signs gross findings orally experimental infection A137R p11.5 serological ELISA virus virulence long-term clinical studies live-attenuated vaccines ASFV-G-∆I177L disinfectant inactivation control genotype whole genome sequencing Uganda African Swine Fever disease control conjoint analysis SWOT analysis risk factors the Philippines multiplex crystal digital PCR (multiplex cdPCR) multiplex real-time quantitative PCR (multiplex qPCR) gene-deleted strain wild-type strain antiviral mitigation glycerol monolaurate monoglyceride Dominican Republic spatial temporal quantitative biosecurity pig swine chronization immunopathology histopathology clinics African swine fever smallholder pig farmers participatory epidemiology control and preventive measures acceptability ASFV vaccine ASFV-G-Δ9GL/ΔUK virus diagnostics boar semen commercial qPCR kits comparison nucleic acid extraction sensitivity performance antigenic epitope T-cell epitope B-cell epitope Vaccine adjuvants dosing study feeding transmission oral uptake n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine::MBNS Epidemiology and Medical statistics African swine fever (ASF) is a highly lethal and contagious viral disease found in domestic pigs, wild boars, and wild suids, and it has significant economic consequences. This disease is currently endemic in many parts of the world, but the lack of an effective commercial vaccine for prevention and control makes the threat of ASF spreading to ASF-free regions more prominent. Currently, the emergence of a new highly lethal genotype I and II recombinant African swine fever viruses disrupted the ability of available vaccine candidates against genotype II in order to protect pigs against ASF. The emergence of this recombinant virus is an example of the complex dynamics that involve the natural infectious cycle of this pathogen. Currently, more research studies are needed to improve the control of ASF. These collections of studies include the areas of control (vaccination, drugs, disinfectants, and immunology), epidemiology, pathogenesis, and diagnostics. The studies compiled in this Reprint contribute to improving the knowledge of several critical aspects of this complex disease. I encourage the scientific community of ASFV to review these published studies. 2025-08-12T09:53:59Z 2025-08-12T09:53:59Z 2025 book ONIX_20250812T110751_9783725840380_302 9783725840380 9783725840373 https://directory.doabooks.org/handle/20.500.12854/165547 eng image/jpeg Attribution 4.0 International https://mdpi.com/books https://mdpi.com/books/pdfview/book/11001 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-4037-3 10.3390/books978-3-7258-4037-3 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725840380 9783725840373 280 open access |
| spellingShingle | African swine fever virus central variable region single-nucleotide polymorphism phylogenetic analysis ASFV ASF virus neutralizing antibodies protective immunity pathology Germany virus variant wild boar natural infection African swine fever virus (ASFV) RNA-seq innate immunity inflammation NF-κB signaling pathway epidemiology prevalence wild boar population density spread control measures clinical signs gross findings orally experimental infection A137R p11.5 serological ELISA virus virulence long-term clinical studies live-attenuated vaccines ASFV-G-∆I177L disinfectant inactivation control genotype whole genome sequencing Uganda African Swine Fever disease control conjoint analysis SWOT analysis risk factors the Philippines multiplex crystal digital PCR (multiplex cdPCR) multiplex real-time quantitative PCR (multiplex qPCR) gene-deleted strain wild-type strain antiviral mitigation glycerol monolaurate monoglyceride Dominican Republic spatial temporal quantitative biosecurity pig swine chronization immunopathology histopathology clinics African swine fever smallholder pig farmers participatory epidemiology control and preventive measures acceptability ASFV vaccine ASFV-G-Δ9GL/ΔUK virus diagnostics boar semen commercial qPCR kits comparison nucleic acid extraction sensitivity performance antigenic epitope T-cell epitope B-cell epitope Vaccine adjuvants dosing study feeding transmission oral uptake n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine::MBNS Epidemiology and Medical statistics Emergence and Control of African Swine Fever |
| title | Emergence and Control of African Swine Fever |
| title_full | Emergence and Control of African Swine Fever |
| title_fullStr | Emergence and Control of African Swine Fever |
| title_full_unstemmed | Emergence and Control of African Swine Fever |
| title_short | Emergence and Control of African Swine Fever |
| title_sort | emergence and control of african swine fever |
| topic | African swine fever virus central variable region single-nucleotide polymorphism phylogenetic analysis ASFV ASF virus neutralizing antibodies protective immunity pathology Germany virus variant wild boar natural infection African swine fever virus (ASFV) RNA-seq innate immunity inflammation NF-κB signaling pathway epidemiology prevalence wild boar population density spread control measures clinical signs gross findings orally experimental infection A137R p11.5 serological ELISA virus virulence long-term clinical studies live-attenuated vaccines ASFV-G-∆I177L disinfectant inactivation control genotype whole genome sequencing Uganda African Swine Fever disease control conjoint analysis SWOT analysis risk factors the Philippines multiplex crystal digital PCR (multiplex cdPCR) multiplex real-time quantitative PCR (multiplex qPCR) gene-deleted strain wild-type strain antiviral mitigation glycerol monolaurate monoglyceride Dominican Republic spatial temporal quantitative biosecurity pig swine chronization immunopathology histopathology clinics African swine fever smallholder pig farmers participatory epidemiology control and preventive measures acceptability ASFV vaccine ASFV-G-Δ9GL/ΔUK virus diagnostics boar semen commercial qPCR kits comparison nucleic acid extraction sensitivity performance antigenic epitope T-cell epitope B-cell epitope Vaccine adjuvants dosing study feeding transmission oral uptake n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine::MBNS Epidemiology and Medical statistics |
| topic_facet | African swine fever virus central variable region single-nucleotide polymorphism phylogenetic analysis ASFV ASF virus neutralizing antibodies protective immunity pathology Germany virus variant wild boar natural infection African swine fever virus (ASFV) RNA-seq innate immunity inflammation NF-κB signaling pathway epidemiology prevalence wild boar population density spread control measures clinical signs gross findings orally experimental infection A137R p11.5 serological ELISA virus virulence long-term clinical studies live-attenuated vaccines ASFV-G-∆I177L disinfectant inactivation control genotype whole genome sequencing Uganda African Swine Fever disease control conjoint analysis SWOT analysis risk factors the Philippines multiplex crystal digital PCR (multiplex cdPCR) multiplex real-time quantitative PCR (multiplex qPCR) gene-deleted strain wild-type strain antiviral mitigation glycerol monolaurate monoglyceride Dominican Republic spatial temporal quantitative biosecurity pig swine chronization immunopathology histopathology clinics African swine fever smallholder pig farmers participatory epidemiology control and preventive measures acceptability ASFV vaccine ASFV-G-Δ9GL/ΔUK virus diagnostics boar semen commercial qPCR kits comparison nucleic acid extraction sensitivity performance antigenic epitope T-cell epitope B-cell epitope Vaccine adjuvants dosing study feeding transmission oral uptake n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine::MBNS Epidemiology and Medical statistics |
| url | ONIX_20250812T110751_9783725840380_302 |