Zebrafish
Zebrafish are an attractive vertebrate model used in drug discovery. Due to their small size, external development, and transparency, zebrafish embryos are compatible with multiwell plates for high-throughput screening. Based on the availability of zebrafish genome sequences, the ease of creating tr...
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| Materialtyp: | Online |
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| Språk: | engelska |
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MDPI - Multidisciplinary Digital Publishing Institute
2025
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| Länkar: | ONIX_20250812T110751_9783725842025_377 |
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| _version_ | 1869529678283276288 |
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| collection | Directory of Open Access Books |
| description | Zebrafish are an attractive vertebrate model used in drug discovery. Due to their small size, external development, and transparency, zebrafish embryos are compatible with multiwell plates for high-throughput screening. Based on the availability of zebrafish genome sequences, the ease of creating transgenic and genetic mutants, and the conservation of signal transduction pathways, a variety of human diseases have been modeled using zebrafish. Moreover, biological pathways, such as physiological and molecular events, which control the development and function of most organ systems, including the cardiovascular, skeletal, nervous, digestive, and visual systems of zebrafish, are similar to those in mammals. The zebrafish reference genome published in 2013 has further accelerated the use of zebrafish in human disease modeling. Over the last two decades, zebrafish have become popular in pharmaceutical and toxicological research. Consequently, several drugs used to treat human diseases (including tuberculosis, neuronal, and auditory disorders, as well as several types of cancer) have been identified from zebrafish screens. Such advances in this area of research have established zebrafish as an invaluable human disease model. This collection of articles aims to cover current research and provide an overview of the advances made in the area of drug discovery and disease modeling using the zebrafish model. |
| format | Online |
| id | doab-20.500.12854ir-165622 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1656222025-08-12T10:01:07Z Zebrafish Kanungo, Jyotshna arsenic zebrafish Sonic hedgehog autism motor neuron deafferentation olfactory bulb mitral cell retrograde labeling teleost angiotensin-converting enzyme inflammatory bowel disease enteritis zebrafish model congenital heart defects single-defect heart disease heart disease syndrome phaeochromocytoma paraganglioma succinate dehydrogenase subunit B (SDHB) valproic acid animal model autism spectrum disorder social behavior neurotransmitter slc1a4 single Mauthner cell Gap43 CNS axon regeneration social discrimination albino oxytocin predator vitamin B6 hypophosphatasia alpl deficiency direct-infusion high-resolution mass spectrometry n/a Zebrafish are an attractive vertebrate model used in drug discovery. Due to their small size, external development, and transparency, zebrafish embryos are compatible with multiwell plates for high-throughput screening. Based on the availability of zebrafish genome sequences, the ease of creating transgenic and genetic mutants, and the conservation of signal transduction pathways, a variety of human diseases have been modeled using zebrafish. Moreover, biological pathways, such as physiological and molecular events, which control the development and function of most organ systems, including the cardiovascular, skeletal, nervous, digestive, and visual systems of zebrafish, are similar to those in mammals. The zebrafish reference genome published in 2013 has further accelerated the use of zebrafish in human disease modeling. Over the last two decades, zebrafish have become popular in pharmaceutical and toxicological research. Consequently, several drugs used to treat human diseases (including tuberculosis, neuronal, and auditory disorders, as well as several types of cancer) have been identified from zebrafish screens. Such advances in this area of research have established zebrafish as an invaluable human disease model. This collection of articles aims to cover current research and provide an overview of the advances made in the area of drug discovery and disease modeling using the zebrafish model. 2025-08-12T10:01:05Z 2025-08-12T10:01:05Z 2025 book ONIX_20250812T110751_9783725842025_377 9783725842025 9783725842018 https://directory.doabooks.org/handle/20.500.12854/165622 eng image/jpeg Attribution 4.0 International https://mdpi.com/books https://mdpi.com/books/pdfview/book/11031 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-4201-8 10.3390/books978-3-7258-4201-8 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725842025 9783725842018 166 open access |
| spellingShingle | arsenic zebrafish Sonic hedgehog autism motor neuron deafferentation olfactory bulb mitral cell retrograde labeling teleost angiotensin-converting enzyme inflammatory bowel disease enteritis zebrafish model congenital heart defects single-defect heart disease heart disease syndrome phaeochromocytoma paraganglioma succinate dehydrogenase subunit B (SDHB) valproic acid animal model autism spectrum disorder social behavior neurotransmitter slc1a4 single Mauthner cell Gap43 CNS axon regeneration social discrimination albino oxytocin predator vitamin B6 hypophosphatasia alpl deficiency direct-infusion high-resolution mass spectrometry n/a Zebrafish |
| title | Zebrafish |
| title_full | Zebrafish |
| title_fullStr | Zebrafish |
| title_full_unstemmed | Zebrafish |
| title_short | Zebrafish |
| title_sort | zebrafish |
| topic | arsenic zebrafish Sonic hedgehog autism motor neuron deafferentation olfactory bulb mitral cell retrograde labeling teleost angiotensin-converting enzyme inflammatory bowel disease enteritis zebrafish model congenital heart defects single-defect heart disease heart disease syndrome phaeochromocytoma paraganglioma succinate dehydrogenase subunit B (SDHB) valproic acid animal model autism spectrum disorder social behavior neurotransmitter slc1a4 single Mauthner cell Gap43 CNS axon regeneration social discrimination albino oxytocin predator vitamin B6 hypophosphatasia alpl deficiency direct-infusion high-resolution mass spectrometry n/a |
| topic_facet | arsenic zebrafish Sonic hedgehog autism motor neuron deafferentation olfactory bulb mitral cell retrograde labeling teleost angiotensin-converting enzyme inflammatory bowel disease enteritis zebrafish model congenital heart defects single-defect heart disease heart disease syndrome phaeochromocytoma paraganglioma succinate dehydrogenase subunit B (SDHB) valproic acid animal model autism spectrum disorder social behavior neurotransmitter slc1a4 single Mauthner cell Gap43 CNS axon regeneration social discrimination albino oxytocin predator vitamin B6 hypophosphatasia alpl deficiency direct-infusion high-resolution mass spectrometry n/a |
| url | ONIX_20250812T110751_9783725842025_377 |