Emerging Topics in Metal Complexes
Due to their pharmacological potential, metal complexes and compounds have been arousing the interest of many research centers worldwide. The structure and properties of many metal coordination compounds make them therapeutically effective. They are used not only in the treatment of some modern-age...
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| Language: | English |
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MDPI - Multidisciplinary Digital Publishing Institute
2025
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| Online Access: | ONIX_20250812T110751_9783725843404_440 |
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| description | Due to their pharmacological potential, metal complexes and compounds have been arousing the interest of many research centers worldwide. The structure and properties of many metal coordination compounds make them therapeutically effective. They are used not only in the treatment of some modern-age diseases but also in clinical diagnostics. Currently, metal complexes and compounds (such as polyoxometalates) are prominent players in medicine and medicinal chemistry. Despite the progress in the knowledge of the pharmacological activity of certain metals and their complexes, further studies are still needed, as the mechanisms of action of the potential drugs containing metal ions are not sufficiently recognized yet. Moreover, the side effects of the use of metal coordination compounds in the treatment of some diseases (mainly cancer) and resistance to treatment are a serious problem in modern medicine. Therefore, there is a constant search for new therapeutics based on metal complexes that would ensure better treatment results and contribute to a significant slowdown in the progression of diseases. The therapeutic targets, bioavailability, and pharmacokinetics of metal-containing compounds have to be clarified in detail with reference to metal-based drugs, which may guarantee potential clinical success. |
| format | Online |
| id | doab-20.500.12854ir-165685 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1656852025-08-12T10:06:56Z Emerging Topics in Metal Complexes Ścibior, Agnieszka Llopis, Juan Aureliano, Manuel vanadium neurodegenerative diseases neurological/neurobehavioral effects environmental/occupational exposure humans body fluids brain copper mineral nutrition mitochondria DNA iron zinc magnesium chromium trace elements SEM biofortification atomic absorption spectrometry wheat sprouts UV seed sterilization nutrient deficiency platinum(IV) prodrugs structure–activity relationship anticancer indenoisoquinoline copper(II) complex topoisomerase I adenocarcinoma molecular modeling DNA intercalation antimicrobial cytotoxicity decavanadate DFT calculations guanidine guanylurea isoquinoline derivatives copper(II) complexes synthesis structural stability studies antitumor antioxidant properties ADME analysis blood gas analysis CO-oximetry status biochemical parameters histological analysis in vitro computed tomography imaging in vivo toxicity monolacunary Wells-Dawson polyoxotungstate tissue distribution X-ray attenuation Schiff base iminopyridine metal complex bacteria antibiotic Staphylococcus aureus Escherichia coli n/a thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Due to their pharmacological potential, metal complexes and compounds have been arousing the interest of many research centers worldwide. The structure and properties of many metal coordination compounds make them therapeutically effective. They are used not only in the treatment of some modern-age diseases but also in clinical diagnostics. Currently, metal complexes and compounds (such as polyoxometalates) are prominent players in medicine and medicinal chemistry. Despite the progress in the knowledge of the pharmacological activity of certain metals and their complexes, further studies are still needed, as the mechanisms of action of the potential drugs containing metal ions are not sufficiently recognized yet. Moreover, the side effects of the use of metal coordination compounds in the treatment of some diseases (mainly cancer) and resistance to treatment are a serious problem in modern medicine. Therefore, there is a constant search for new therapeutics based on metal complexes that would ensure better treatment results and contribute to a significant slowdown in the progression of diseases. The therapeutic targets, bioavailability, and pharmacokinetics of metal-containing compounds have to be clarified in detail with reference to metal-based drugs, which may guarantee potential clinical success. 2025-08-12T10:06:54Z 2025-08-12T10:06:54Z 2025 book ONIX_20250812T110751_9783725843404_440 9783725843404 9783725843398 https://directory.doabooks.org/handle/20.500.12854/165685 eng image/jpeg Attribution 4.0 International https://mdpi.com/books https://mdpi.com/books/pdfview/book/11037 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-4339-8 10.3390/books978-3-7258-4339-8 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725843404 9783725843398 194 open access |
| spellingShingle | vanadium neurodegenerative diseases neurological/neurobehavioral effects environmental/occupational exposure humans body fluids brain copper mineral nutrition mitochondria DNA iron zinc magnesium chromium trace elements SEM biofortification atomic absorption spectrometry wheat sprouts UV seed sterilization nutrient deficiency platinum(IV) prodrugs structure–activity relationship anticancer indenoisoquinoline copper(II) complex topoisomerase I adenocarcinoma molecular modeling DNA intercalation antimicrobial cytotoxicity decavanadate DFT calculations guanidine guanylurea isoquinoline derivatives copper(II) complexes synthesis structural stability studies antitumor antioxidant properties ADME analysis blood gas analysis CO-oximetry status biochemical parameters histological analysis in vitro computed tomography imaging in vivo toxicity monolacunary Wells-Dawson polyoxotungstate tissue distribution X-ray attenuation Schiff base iminopyridine metal complex bacteria antibiotic Staphylococcus aureus Escherichia coli n/a thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Emerging Topics in Metal Complexes |
| title | Emerging Topics in Metal Complexes |
| title_full | Emerging Topics in Metal Complexes |
| title_fullStr | Emerging Topics in Metal Complexes |
| title_full_unstemmed | Emerging Topics in Metal Complexes |
| title_short | Emerging Topics in Metal Complexes |
| title_sort | emerging topics in metal complexes |
| topic | vanadium neurodegenerative diseases neurological/neurobehavioral effects environmental/occupational exposure humans body fluids brain copper mineral nutrition mitochondria DNA iron zinc magnesium chromium trace elements SEM biofortification atomic absorption spectrometry wheat sprouts UV seed sterilization nutrient deficiency platinum(IV) prodrugs structure–activity relationship anticancer indenoisoquinoline copper(II) complex topoisomerase I adenocarcinoma molecular modeling DNA intercalation antimicrobial cytotoxicity decavanadate DFT calculations guanidine guanylurea isoquinoline derivatives copper(II) complexes synthesis structural stability studies antitumor antioxidant properties ADME analysis blood gas analysis CO-oximetry status biochemical parameters histological analysis in vitro computed tomography imaging in vivo toxicity monolacunary Wells-Dawson polyoxotungstate tissue distribution X-ray attenuation Schiff base iminopyridine metal complex bacteria antibiotic Staphylococcus aureus Escherichia coli n/a thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | vanadium neurodegenerative diseases neurological/neurobehavioral effects environmental/occupational exposure humans body fluids brain copper mineral nutrition mitochondria DNA iron zinc magnesium chromium trace elements SEM biofortification atomic absorption spectrometry wheat sprouts UV seed sterilization nutrient deficiency platinum(IV) prodrugs structure–activity relationship anticancer indenoisoquinoline copper(II) complex topoisomerase I adenocarcinoma molecular modeling DNA intercalation antimicrobial cytotoxicity decavanadate DFT calculations guanidine guanylurea isoquinoline derivatives copper(II) complexes synthesis structural stability studies antitumor antioxidant properties ADME analysis blood gas analysis CO-oximetry status biochemical parameters histological analysis in vitro computed tomography imaging in vivo toxicity monolacunary Wells-Dawson polyoxotungstate tissue distribution X-ray attenuation Schiff base iminopyridine metal complex bacteria antibiotic Staphylococcus aureus Escherichia coli n/a thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20250812T110751_9783725843404_440 |