Cellular Responses of Antioxidants Related to Degenerative Eye Disease Research
Oxidative stress is critical in degenerative retinal diseases. Antioxidants are considered to be potential therapeutics that can treat retinal diseases. Loss of retinal epithelium (RPE) is an important contributor to the degeneration of the retina. Dry AMD induces straight RPE cell degeneration, whe...
Sparad:
| Materialtyp: | Online |
|---|---|
| Språk: | engelska |
| Utgiven: |
MDPI - Multidisciplinary Digital Publishing Institute
2025
|
| Ämnen: | |
| Länkar: | ONIX_20250812T110751_9783725845279_528 |
| Taggar: |
Inga taggar, Lägg till första taggen!
|
| _version_ | 1869529518245412864 |
|---|---|
| collection | Directory of Open Access Books |
| description | Oxidative stress is critical in degenerative retinal diseases. Antioxidants are considered to be potential therapeutics that can treat retinal diseases. Loss of retinal epithelium (RPE) is an important contributor to the degeneration of the retina. Dry AMD induces straight RPE cell degeneration, whereas the wet form causes neovascularization following RPE cell loss. Glaucoma induces progressive retinal ganglion cell (RGC) axon degeneration, resulting in RGC death and visual deficits. RPE cells are also important regulators in eye growth and thus are also susceptible to participating in retinal detachment in myopia. In diabetic retinopathy, the RPE barrier breaks, leading to vascular leakage. The retina is a thin layer in the posterior part of the eye that collects visual information and transfers it to the brain via the optic nerve. Retina consists of RPE cells, photoreceptor rods and cones, glial cells, and neuronal cells, including RGCs. RPE cells support homeostasis by performing a heterocycle of outer photoreceptor segments, enabling nutritional transport from the choroid and removing waste material into the choroid, for example. RPE degeneration leads to vision loss, and antioxidants could protect these cells against oxidative stress, mitochondrial dysfunction, and inflammation, all important contributors to retinal degeneration. This Special Issue is a collection of studies related to cellular responses to oxidative stress and antioxidants in pre-clinical degenerative retinal eye disease research. It includes articles about different aspects of oxidative stress and antioxidants in degenerative retinal diseases. |
| format | Online |
| id | doab-20.500.12854ir-165773 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1657732025-08-12T10:15:34Z Cellular Responses of Antioxidants Related to Degenerative Eye Disease Research Ju, Wonkyu Harju, Niina antioxidants retinal degeneration oxidative stress retinal pigment epithelial cells thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Oxidative stress is critical in degenerative retinal diseases. Antioxidants are considered to be potential therapeutics that can treat retinal diseases. Loss of retinal epithelium (RPE) is an important contributor to the degeneration of the retina. Dry AMD induces straight RPE cell degeneration, whereas the wet form causes neovascularization following RPE cell loss. Glaucoma induces progressive retinal ganglion cell (RGC) axon degeneration, resulting in RGC death and visual deficits. RPE cells are also important regulators in eye growth and thus are also susceptible to participating in retinal detachment in myopia. In diabetic retinopathy, the RPE barrier breaks, leading to vascular leakage. The retina is a thin layer in the posterior part of the eye that collects visual information and transfers it to the brain via the optic nerve. Retina consists of RPE cells, photoreceptor rods and cones, glial cells, and neuronal cells, including RGCs. RPE cells support homeostasis by performing a heterocycle of outer photoreceptor segments, enabling nutritional transport from the choroid and removing waste material into the choroid, for example. RPE degeneration leads to vision loss, and antioxidants could protect these cells against oxidative stress, mitochondrial dysfunction, and inflammation, all important contributors to retinal degeneration. This Special Issue is a collection of studies related to cellular responses to oxidative stress and antioxidants in pre-clinical degenerative retinal eye disease research. It includes articles about different aspects of oxidative stress and antioxidants in degenerative retinal diseases. 2025-08-12T10:15:32Z 2025-08-12T10:15:32Z 2025 book ONIX_20250812T110751_9783725845279_528 9783725845279 9783725845286 https://directory.doabooks.org/handle/20.500.12854/165773 eng image/jpeg Attribution 4.0 International https://mdpi.com/books https://mdpi.com/books/pdfview/book/11232 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-4528-6 10.3390/books978-3-7258-4528-6 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725845279 9783725845286 194 open access |
| spellingShingle | antioxidants retinal degeneration oxidative stress retinal pigment epithelial cells thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Cellular Responses of Antioxidants Related to Degenerative Eye Disease Research |
| title | Cellular Responses of Antioxidants Related to Degenerative Eye Disease Research |
| title_full | Cellular Responses of Antioxidants Related to Degenerative Eye Disease Research |
| title_fullStr | Cellular Responses of Antioxidants Related to Degenerative Eye Disease Research |
| title_full_unstemmed | Cellular Responses of Antioxidants Related to Degenerative Eye Disease Research |
| title_short | Cellular Responses of Antioxidants Related to Degenerative Eye Disease Research |
| title_sort | cellular responses of antioxidants related to degenerative eye disease research |
| topic | antioxidants retinal degeneration oxidative stress retinal pigment epithelial cells thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | antioxidants retinal degeneration oxidative stress retinal pigment epithelial cells thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20250812T110751_9783725845279_528 |