Neurotrauma
This Reprint presents eight peer-reviewed studies on the pathophysiology and treatment of neurotrauma. The collection addresses traumatic brain and spinal cord injuries through both mechanistic investigations and clinical applications. Its topics include the following: the effects of subanesthetic k...
Salvato in:
| Natura: | Online |
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| Lingua: | inglese |
| Pubblicazione: |
MDPI - Multidisciplinary Digital Publishing Institute
2025
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| Soggetti: | |
| Accesso online: | ONIX_20250812T110751_9783725846252_568 |
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| _version_ | 1869527447617142784 |
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| collection | Directory of Open Access Books |
| description | This Reprint presents eight peer-reviewed studies on the pathophysiology and treatment of neurotrauma. The collection addresses traumatic brain and spinal cord injuries through both mechanistic investigations and clinical applications. Its topics include the following: the effects of subanesthetic ketamine on stress hormones and synaptic density following mild traumatic brain injury; mesenchymal stem cell-derived exosomes as a potential regenerative therapy; selective COX-2 inhibitors for neuroprotection; monoclonal antibody therapies targeting post-traumatic inflammation; the implementation of artificial intelligence in traumatic brain injury management, along with its associated ethical considerations; diagnostic challenges in traumatic encephalopathy syndrome; cellular mechanisms underlying clinical outcomes in neurotrauma; and neurophysiological evidence that unilateral brachial plexus injuries affect bilateral neural transmission. The research methodologies presented in this Reprint range from rodent models to clinical neurophysiology, encompassing molecular pathways, imaging techniques, biomarker development, and therapeutic strategies. These contributions document current understanding of primary and secondary injury cascades—including inflammation, oxidative stress, and excitotoxicity—while evaluating interventions aimed at neuroprotection and regeneration. The compilation is intended to serve as a useful resource for researchers and clinicians working to improve outcomes for the millions of individuals who are affected annually by neurotrauma. |
| format | Online |
| id | doab-20.500.12854ir-165813 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1658132025-08-12T10:19:16Z Neurotrauma Pierre, Kevin Lucke-Wold, Brandon chronic traumatic encephalopathy (CTE) Alzheimer’s disease (AD) traumatic encephalopathy syndrome (TES) traumatic brain injury (TBI) repetitive head impacts (RHI) CNS traumatic brain injury spinal cord injury neuroregeneration neurotrauma neuroprotection brachial plexus injury cervical roots Erb’s point magnetic stimulation electrical stimulation electroneurography electromyography neuroinflammation inflammation cyclooxygenase Alzheimer’s disease mesenchymal stem cells drug discovery and development neurosurgery neurology novel therapies TBI artificial intelligence machine learning diagnostic neuromonitoring monoclonal antibodies (mAbs) monoclonal antibody therapy secondary injury cascades pathological TBI processes oxidative stress coagulopathy neurodegeneration neurotoxicity blood–brain barrier (BBB) dysfunction neurological diseases ketamine mild traumatic brain injury stress hormone synaptic density rat CHIMERA prefrontal cortex hippocampus thema EDItEUR::M Medicine and Nursing This Reprint presents eight peer-reviewed studies on the pathophysiology and treatment of neurotrauma. The collection addresses traumatic brain and spinal cord injuries through both mechanistic investigations and clinical applications. Its topics include the following: the effects of subanesthetic ketamine on stress hormones and synaptic density following mild traumatic brain injury; mesenchymal stem cell-derived exosomes as a potential regenerative therapy; selective COX-2 inhibitors for neuroprotection; monoclonal antibody therapies targeting post-traumatic inflammation; the implementation of artificial intelligence in traumatic brain injury management, along with its associated ethical considerations; diagnostic challenges in traumatic encephalopathy syndrome; cellular mechanisms underlying clinical outcomes in neurotrauma; and neurophysiological evidence that unilateral brachial plexus injuries affect bilateral neural transmission. The research methodologies presented in this Reprint range from rodent models to clinical neurophysiology, encompassing molecular pathways, imaging techniques, biomarker development, and therapeutic strategies. These contributions document current understanding of primary and secondary injury cascades—including inflammation, oxidative stress, and excitotoxicity—while evaluating interventions aimed at neuroprotection and regeneration. The compilation is intended to serve as a useful resource for researchers and clinicians working to improve outcomes for the millions of individuals who are affected annually by neurotrauma. 2025-08-12T10:19:14Z 2025-08-12T10:19:14Z 2025 book ONIX_20250812T110751_9783725846252_568 9783725846252 9783725846269 https://directory.doabooks.org/handle/20.500.12854/165813 eng image/jpeg Attribution 4.0 International https://mdpi.com/books https://mdpi.com/books/pdfview/book/11222 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-4626-9 10.3390/books978-3-7258-4626-9 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725846252 9783725846269 172 open access |
| spellingShingle | chronic traumatic encephalopathy (CTE) Alzheimer’s disease (AD) traumatic encephalopathy syndrome (TES) traumatic brain injury (TBI) repetitive head impacts (RHI) CNS traumatic brain injury spinal cord injury neuroregeneration neurotrauma neuroprotection brachial plexus injury cervical roots Erb’s point magnetic stimulation electrical stimulation electroneurography electromyography neuroinflammation inflammation cyclooxygenase Alzheimer’s disease mesenchymal stem cells drug discovery and development neurosurgery neurology novel therapies TBI artificial intelligence machine learning diagnostic neuromonitoring monoclonal antibodies (mAbs) monoclonal antibody therapy secondary injury cascades pathological TBI processes oxidative stress coagulopathy neurodegeneration neurotoxicity blood–brain barrier (BBB) dysfunction neurological diseases ketamine mild traumatic brain injury stress hormone synaptic density rat CHIMERA prefrontal cortex hippocampus thema EDItEUR::M Medicine and Nursing Neurotrauma |
| title | Neurotrauma |
| title_full | Neurotrauma |
| title_fullStr | Neurotrauma |
| title_full_unstemmed | Neurotrauma |
| title_short | Neurotrauma |
| title_sort | neurotrauma |
| topic | chronic traumatic encephalopathy (CTE) Alzheimer’s disease (AD) traumatic encephalopathy syndrome (TES) traumatic brain injury (TBI) repetitive head impacts (RHI) CNS traumatic brain injury spinal cord injury neuroregeneration neurotrauma neuroprotection brachial plexus injury cervical roots Erb’s point magnetic stimulation electrical stimulation electroneurography electromyography neuroinflammation inflammation cyclooxygenase Alzheimer’s disease mesenchymal stem cells drug discovery and development neurosurgery neurology novel therapies TBI artificial intelligence machine learning diagnostic neuromonitoring monoclonal antibodies (mAbs) monoclonal antibody therapy secondary injury cascades pathological TBI processes oxidative stress coagulopathy neurodegeneration neurotoxicity blood–brain barrier (BBB) dysfunction neurological diseases ketamine mild traumatic brain injury stress hormone synaptic density rat CHIMERA prefrontal cortex hippocampus thema EDItEUR::M Medicine and Nursing |
| topic_facet | chronic traumatic encephalopathy (CTE) Alzheimer’s disease (AD) traumatic encephalopathy syndrome (TES) traumatic brain injury (TBI) repetitive head impacts (RHI) CNS traumatic brain injury spinal cord injury neuroregeneration neurotrauma neuroprotection brachial plexus injury cervical roots Erb’s point magnetic stimulation electrical stimulation electroneurography electromyography neuroinflammation inflammation cyclooxygenase Alzheimer’s disease mesenchymal stem cells drug discovery and development neurosurgery neurology novel therapies TBI artificial intelligence machine learning diagnostic neuromonitoring monoclonal antibodies (mAbs) monoclonal antibody therapy secondary injury cascades pathological TBI processes oxidative stress coagulopathy neurodegeneration neurotoxicity blood–brain barrier (BBB) dysfunction neurological diseases ketamine mild traumatic brain injury stress hormone synaptic density rat CHIMERA prefrontal cortex hippocampus thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20250812T110751_9783725846252_568 |