Skin-equivalent opto-/elastofluidic in-vitro microphysiological vascular models for translational studies of optical biopsies
The skin equivalent opto-/elastofluidic in-vitro microphysiological vascular models are prepared as the functional validation test charts to evaluate the correctness of the bio-optical measurements/imaging. The opto-/elastofluidic models are constructed with the TiO2/molecular dye insertions. The ti...
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| Formato: | Online |
| Idioma: | inglês |
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FAU University Press
2025
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| Acesso em linha: | ONIX_20251120T102856_9783961475063_41 |
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| _version_ | 1869525342809489408 |
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| author | Chen, Chen |
| author_browse | Chen, Chen |
| author_facet | Chen, Chen |
| author_sort | Chen, Chen |
| collection | Directory of Open Access Books |
| description | The skin equivalent opto-/elastofluidic in-vitro microphysiological vascular models are prepared as the functional validation test charts to evaluate the correctness of the bio-optical measurements/imaging. The opto-/elastofluidic models are constructed with the TiO2/molecular dye insertions. The tissue equivalences to the cutaneous tissue of human are characterized. It is proved that these opto-/elastofluidics can withstand high liquid pressure up to 6 bar and high flow rate of 10 mL/min to allow the simulation of the real blood hydraulics. It is also proved that the in-vivo skin optical parameters μa and μ‘s of the human volunteers match the elastofluidic phantoms. The Young’s moduli E of the elastofluidic phantom matrices are manipulated to give the same reaction to the mechanical load as the real soft skin cutis. The speed of sound propagating through the PVCp matrices is tailored at 1350 to 1500 m/s, which approach that in the real tissue of about 1540 m/s. The diffuse optical biopsy is built to measure the optical path length factors of all major chromophores of the artificial hemoglobin dilutions included in the phantoms. For both oxy- and deoxygenated hemoglobin, the concentration dependencies of the optical path length factors are defined as fPf (Ct) ~ Ct-0.5. Preliminary human experiments are done on the suspicious spider nevi and the embedded nodule lesion, and prove the tissue equivalences of the microphysiological elastofluidic skin models. |
| format | Online |
| id | doab-20.500.12854ir-169098 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | FAU University Press |
| publisherStr | FAU University Press |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1690982025-11-22T05:55:16Z Skin-equivalent opto-/elastofluidic in-vitro microphysiological vascular models for translational studies of optical biopsies Chen, Chen Microphysiological model Optical biopsy Elastofluidic Microfluidic Bio-photonics thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBG Medical equipment and techniques::MBGL Medical laboratory testing and techniques thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science::TGMP Engineering applications of polymers and composites The skin equivalent opto-/elastofluidic in-vitro microphysiological vascular models are prepared as the functional validation test charts to evaluate the correctness of the bio-optical measurements/imaging. The opto-/elastofluidic models are constructed with the TiO2/molecular dye insertions. The tissue equivalences to the cutaneous tissue of human are characterized. It is proved that these opto-/elastofluidics can withstand high liquid pressure up to 6 bar and high flow rate of 10 mL/min to allow the simulation of the real blood hydraulics. It is also proved that the in-vivo skin optical parameters μa and μ‘s of the human volunteers match the elastofluidic phantoms. The Young’s moduli E of the elastofluidic phantom matrices are manipulated to give the same reaction to the mechanical load as the real soft skin cutis. The speed of sound propagating through the PVCp matrices is tailored at 1350 to 1500 m/s, which approach that in the real tissue of about 1540 m/s. The diffuse optical biopsy is built to measure the optical path length factors of all major chromophores of the artificial hemoglobin dilutions included in the phantoms. For both oxy- and deoxygenated hemoglobin, the concentration dependencies of the optical path length factors are defined as fPf (Ct) ~ Ct-0.5. Preliminary human experiments are done on the suspicious spider nevi and the embedded nodule lesion, and prove the tissue equivalences of the microphysiological elastofluidic skin models. 2025-11-21T05:13:19Z 2025-11-21T05:13:19Z 2025-11-20T09:34:05Z 2022 book ONIX_20251120T102856_9783961475063_41 https://library.oapen.org/handle/20.500.12657/108253 9783961475063 9783961475056 https://directory.doabooks.org/handle/20.500.12854/169098 eng FAU Studien aus dem Maschinenbau open access image/jpeg Attribution-NonCommercial 4.0 International https://library.oapen.org/bitstream/20.500.12657/108253/1/9783961475063.pdf FAU University Press 10.25593/978-3-96147-506-3 10.25593/978-3-96147-506-3 2c600dea-eece-4066-87be-da335e323fdb 9783961475063 9783961475056 126 Erlangen open access |
| spellingShingle | Microphysiological model Optical biopsy Elastofluidic Microfluidic Bio-photonics thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBG Medical equipment and techniques::MBGL Medical laboratory testing and techniques thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science::TGMP Engineering applications of polymers and composites Chen, Chen Skin-equivalent opto-/elastofluidic in-vitro microphysiological vascular models for translational studies of optical biopsies |
| title | Skin-equivalent opto-/elastofluidic in-vitro microphysiological vascular models for translational studies of optical biopsies |
| title_full | Skin-equivalent opto-/elastofluidic in-vitro microphysiological vascular models for translational studies of optical biopsies |
| title_fullStr | Skin-equivalent opto-/elastofluidic in-vitro microphysiological vascular models for translational studies of optical biopsies |
| title_full_unstemmed | Skin-equivalent opto-/elastofluidic in-vitro microphysiological vascular models for translational studies of optical biopsies |
| title_short | Skin-equivalent opto-/elastofluidic in-vitro microphysiological vascular models for translational studies of optical biopsies |
| title_sort | skin equivalent opto elastofluidic in vitro microphysiological vascular models for translational studies of optical biopsies |
| topic | Microphysiological model Optical biopsy Elastofluidic Microfluidic Bio-photonics thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBG Medical equipment and techniques::MBGL Medical laboratory testing and techniques thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science::TGMP Engineering applications of polymers and composites |
| topic_facet | Microphysiological model Optical biopsy Elastofluidic Microfluidic Bio-photonics thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBG Medical equipment and techniques::MBGL Medical laboratory testing and techniques thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science::TGMP Engineering applications of polymers and composites |
| url | ONIX_20251120T102856_9783961475063_41 |
| work_keys_str_mv | AT chenchen skinequivalentoptoelastofluidicinvitromicrophysiologicalvascularmodelsfortranslationalstudiesofopticalbiopsies |