Metabolic Features and Nutritional Interventions in Chronic Diseases

A growing body of research indicates an extensive metabolic dysfunction in a spectrum of chronic diseases, comprising aging, cancer, and diseases affecting the cardiovascular system, liver, and kidneys. The phenotypes associated with metabolic dysfunction vary depending on disease type and stage. In...

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Argitaratua: MDPI - Multidisciplinary Digital Publishing Institute 2026
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collection Directory of Open Access Books
description A growing body of research indicates an extensive metabolic dysfunction in a spectrum of chronic diseases, comprising aging, cancer, and diseases affecting the cardiovascular system, liver, and kidneys. The phenotypes associated with metabolic dysfunction vary depending on disease type and stage. In turn, the altered metabolism drives disease pathology. Consequently, the nutritional modulation of metabolic status in chronic disease is widely acknowledged to reduce disease incidence. For instance, tailored nutritional intervention in cancers with altered metabolism determines the improved therapeutic responses. Additionally, counteracting muscle loss and osteoporosis are clinical goals of nutritional support in an aged population. Mechanistically, bioactive nutrients or tailored nutritional regimen modulate metabolism through mitochondrial homeostasis, immuno-regulation, as well as epigenome regulation to impact disease progression. This reprint aims to be an interdisciplinary platform that covers (1) characterization of metabolic features and/or nutritional requirement in a certain type of chronic disease; (2) defining the effects and mechanism of a specific nutrient or nutritional intervention on metabolism; (3) development of new nutritional strategy that improves disease outcome by altering metabolism.
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spelling doab-20.500.12854ir-1706342026-01-02T16:19:09Z Metabolic Features and Nutritional Interventions in Chronic Diseases Luo, Yongting Luo, Junjie An, Peng chronic disease metabolic feature metabolic reprogramming bioactive nutrients nutritional intervention A growing body of research indicates an extensive metabolic dysfunction in a spectrum of chronic diseases, comprising aging, cancer, and diseases affecting the cardiovascular system, liver, and kidneys. The phenotypes associated with metabolic dysfunction vary depending on disease type and stage. In turn, the altered metabolism drives disease pathology. Consequently, the nutritional modulation of metabolic status in chronic disease is widely acknowledged to reduce disease incidence. For instance, tailored nutritional intervention in cancers with altered metabolism determines the improved therapeutic responses. Additionally, counteracting muscle loss and osteoporosis are clinical goals of nutritional support in an aged population. Mechanistically, bioactive nutrients or tailored nutritional regimen modulate metabolism through mitochondrial homeostasis, immuno-regulation, as well as epigenome regulation to impact disease progression. This reprint aims to be an interdisciplinary platform that covers (1) characterization of metabolic features and/or nutritional requirement in a certain type of chronic disease; (2) defining the effects and mechanism of a specific nutrient or nutritional intervention on metabolism; (3) development of new nutritional strategy that improves disease outcome by altering metabolism. 2026-01-02T16:19:07Z 2026-01-02T16:19:07Z 2025 book 978-3-7258-4919-2 https://directory.doabooks.org/handle/20.500.12854/170634 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books https://mdpi.com/books/pdfview/book/11362 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-4920-8 10.3390/books978-3-7258-4920-8 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 978-3-7258-4919-2 178 CH open access
spellingShingle chronic disease
metabolic feature
metabolic reprogramming
bioactive nutrients
nutritional intervention
Metabolic Features and Nutritional Interventions in Chronic Diseases
title Metabolic Features and Nutritional Interventions in Chronic Diseases
title_full Metabolic Features and Nutritional Interventions in Chronic Diseases
title_fullStr Metabolic Features and Nutritional Interventions in Chronic Diseases
title_full_unstemmed Metabolic Features and Nutritional Interventions in Chronic Diseases
title_short Metabolic Features and Nutritional Interventions in Chronic Diseases
title_sort metabolic features and nutritional interventions in chronic diseases
topic chronic disease
metabolic feature
metabolic reprogramming
bioactive nutrients
nutritional intervention
topic_facet chronic disease
metabolic feature
metabolic reprogramming
bioactive nutrients
nutritional intervention
url https://directory.doabooks.org/handle/20.500.12854/170634