Advances in Molecular Biology Methods in Hepatology Research
Recent advances in molecular biology methods have profound implications for deciphering the complexities of hepatology research, specifically in understanding liver function, disease development, and novel therapies. The integration of genomic and proteomic technologies such as Next-Generation Seque...
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| Formato: | Online |
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| Idioma: | inglês |
| Publicado em: |
MDPI - Multidisciplinary Digital Publishing Institute
2026
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| Acesso em linha: | ONIX_20260416T142754_9783725852178_35 |
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| collection | Directory of Open Access Books |
| description | Recent advances in molecular biology methods have profound implications for deciphering the complexities of hepatology research, specifically in understanding liver function, disease development, and novel therapies. The integration of genomic and proteomic technologies such as Next-Generation Sequencing (NGS), single-cell sequencing, CRISPR-Cas9, sensitive mass spectrometry, high-throughput proteomics, and epigenetic studies allow for a more comprehensive analysis of the liver's genomic landscape. These technologies enable scientists to understand the molecular pathways involved in liver injury, fibrosis, and regeneration. In addition to advances in genomic techniques, the development of advanced hepatic in vivo models and liver tissue engineering, utilizing technologies such as CRISPR-Cas9, places a clear emphasis on creating humanized organoid models. These molecular innovations, like hepatic organoids, are scalable for high-throughput screening and can replicate complex cellular interactions, providing further insights into the mechanisms underlying liver diseases such as metabolic dysfunction-associated steatotic liver disease (MASLD), hepatitis, and liver fibrosis. By creating patient-derived organoids, researchers can personalize disease models and uncover individualized disease mechanisms and precision therapeutics. Overall, these advancements in molecular biology have propelled hepatology research to the next level, offering additional opportunities for efficient diagnosis, treatment, and prevention strategies for hepatic diseases. |
| format | Online |
| id | doab-20.500.12854ir-174730 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2026 |
| publishDateRange | 2026 |
| publishDateSort | 2026 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1747302026-04-16T16:06:23Z Advances in Molecular Biology Methods in Hepatology Research Nair, Dileep G. Weiskirchen, Ralf Hepatology Molecular Biology Cellular Biology Hepatitis Inflammation Lipopolysaccharides Preclinical drug screening thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Recent advances in molecular biology methods have profound implications for deciphering the complexities of hepatology research, specifically in understanding liver function, disease development, and novel therapies. The integration of genomic and proteomic technologies such as Next-Generation Sequencing (NGS), single-cell sequencing, CRISPR-Cas9, sensitive mass spectrometry, high-throughput proteomics, and epigenetic studies allow for a more comprehensive analysis of the liver's genomic landscape. These technologies enable scientists to understand the molecular pathways involved in liver injury, fibrosis, and regeneration. In addition to advances in genomic techniques, the development of advanced hepatic in vivo models and liver tissue engineering, utilizing technologies such as CRISPR-Cas9, places a clear emphasis on creating humanized organoid models. These molecular innovations, like hepatic organoids, are scalable for high-throughput screening and can replicate complex cellular interactions, providing further insights into the mechanisms underlying liver diseases such as metabolic dysfunction-associated steatotic liver disease (MASLD), hepatitis, and liver fibrosis. By creating patient-derived organoids, researchers can personalize disease models and uncover individualized disease mechanisms and precision therapeutics. Overall, these advancements in molecular biology have propelled hepatology research to the next level, offering additional opportunities for efficient diagnosis, treatment, and prevention strategies for hepatic diseases. 2026-04-16T16:06:16Z 2026-04-16T16:06:16Z 2025 book ONIX_20260416T142754_9783725852178_35 9783725852178 9783725852185 https://directory.doabooks.org/handle/20.500.12854/174730 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/ https://mdpi.com/books/pdfview/book/11605 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-5218-5 10.3390/books978-3-7258-5218-5 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725852178 9783725852185 218 CH open access |
| spellingShingle | Hepatology Molecular Biology Cellular Biology Hepatitis Inflammation Lipopolysaccharides Preclinical drug screening thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Advances in Molecular Biology Methods in Hepatology Research |
| title | Advances in Molecular Biology Methods in Hepatology Research |
| title_full | Advances in Molecular Biology Methods in Hepatology Research |
| title_fullStr | Advances in Molecular Biology Methods in Hepatology Research |
| title_full_unstemmed | Advances in Molecular Biology Methods in Hepatology Research |
| title_short | Advances in Molecular Biology Methods in Hepatology Research |
| title_sort | advances in molecular biology methods in hepatology research |
| topic | Hepatology Molecular Biology Cellular Biology Hepatitis Inflammation Lipopolysaccharides Preclinical drug screening thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | Hepatology Molecular Biology Cellular Biology Hepatitis Inflammation Lipopolysaccharides Preclinical drug screening thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20260416T142754_9783725852178_35 |