RNA Interference Pathways
One of the most important breakthroughs of the 20th century was the discovery of how short RNA molecules from the genomic “dark matter” can control invasive genetic elements or fine-tune endogenous gene expression. The collective name of these pathways is RNA interference (RNAi), or “gene silencing”...
সংরক্ষণ করুন:
| বিন্যাস: | Online |
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| ভাষা: | ইংরেজি |
| প্রকাশিত: |
MDPI - Multidisciplinary Digital Publishing Institute
2026
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | ONIX_20260416T142754_9783725851515_15 |
| ট্যাগগুলো: |
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| _version_ | 1869526351823765504 |
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| collection | Directory of Open Access Books |
| description | One of the most important breakthroughs of the 20th century was the discovery of how short RNA molecules from the genomic “dark matter” can control invasive genetic elements or fine-tune endogenous gene expression. The collective name of these pathways is RNA interference (RNAi), or “gene silencing”, and the main players here are short, single-stranded RNA molecules in complex with Argonaute proteins. The scientific significance of these small RNA-based regulatory pathways was recognized by the awarding of the Nobel Prize in 2006 for the discovery of RNAi and by the recently awarded 2024 Nobel Prize for the discovery of miRNAs. This reprint is mainly a tribute to the diversity of the miRNA pathway. The selected articles provide an overview not only of some molecular aspects of the maturation of these tiny regulators but also provide evidence of how miRNAs control cell proliferation and differentiation and how their misregulation could lead to the formation of various types of cancer. As certain gene therapy applications also involve miRNA-based strategies, the importance of understanding the molecular details of this pathway clearly extends beyond pure scientific interest. This collection of articles not only presents scientific discoveries using cutting-edge technologies in several model systems but also provides evidence of how modern molecular genetics, as well as molecular medicine, can benefit from an in-depth understanding of the miRNA pathway. |
| format | Online |
| id | doab-20.500.12854ir-174760 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2026 |
| publishDateRange | 2026 |
| publishDateSort | 2026 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1747602026-04-16T16:16:30Z RNA Interference Pathways Orban, Tamas RNAi MicroRNA MiRNA cluster Mirtron MiRNA target prediction Stem cells Germ cells Tumor thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences One of the most important breakthroughs of the 20th century was the discovery of how short RNA molecules from the genomic “dark matter” can control invasive genetic elements or fine-tune endogenous gene expression. The collective name of these pathways is RNA interference (RNAi), or “gene silencing”, and the main players here are short, single-stranded RNA molecules in complex with Argonaute proteins. The scientific significance of these small RNA-based regulatory pathways was recognized by the awarding of the Nobel Prize in 2006 for the discovery of RNAi and by the recently awarded 2024 Nobel Prize for the discovery of miRNAs. This reprint is mainly a tribute to the diversity of the miRNA pathway. The selected articles provide an overview not only of some molecular aspects of the maturation of these tiny regulators but also provide evidence of how miRNAs control cell proliferation and differentiation and how their misregulation could lead to the formation of various types of cancer. As certain gene therapy applications also involve miRNA-based strategies, the importance of understanding the molecular details of this pathway clearly extends beyond pure scientific interest. This collection of articles not only presents scientific discoveries using cutting-edge technologies in several model systems but also provides evidence of how modern molecular genetics, as well as molecular medicine, can benefit from an in-depth understanding of the miRNA pathway. 2026-04-16T16:16:24Z 2026-04-16T16:16:24Z 2025 book ONIX_20260416T142754_9783725851515_15 9783725851515 9783725851522 https://directory.doabooks.org/handle/20.500.12854/174760 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/ https://mdpi.com/books/pdfview/book/11638 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-5152-2 10.3390/books978-3-7258-5152-2 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725851515 9783725851522 156 CH open access |
| spellingShingle | RNAi MicroRNA MiRNA cluster Mirtron MiRNA target prediction Stem cells Germ cells Tumor thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences RNA Interference Pathways |
| title | RNA Interference Pathways |
| title_full | RNA Interference Pathways |
| title_fullStr | RNA Interference Pathways |
| title_full_unstemmed | RNA Interference Pathways |
| title_short | RNA Interference Pathways |
| title_sort | rna interference pathways |
| topic | RNAi MicroRNA MiRNA cluster Mirtron MiRNA target prediction Stem cells Germ cells Tumor thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | RNAi MicroRNA MiRNA cluster Mirtron MiRNA target prediction Stem cells Germ cells Tumor thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20260416T142754_9783725851515_15 |