Anticancer Drug Discovery Based on Natural Products
Cancer is heterogeneous and dynamic in nature, and its drug resistance, due to high vulnerability to point mutations, and its aberrant pathways are making it quite challenging to efficiently address and manage. Natural products have always been a mainstream source of anticancer drugs due to the modu...
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| Formato: | Online |
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| Idioma: | inglês |
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MDPI - Multidisciplinary Digital Publishing Institute
2026
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| Acesso em linha: | ONIX_20260416T142754_9783725852772_35 |
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| description | Cancer is heterogeneous and dynamic in nature, and its drug resistance, due to high vulnerability to point mutations, and its aberrant pathways are making it quite challenging to efficiently address and manage. Natural products have always been a mainstream source of anticancer drugs due to the modulation of multiple hallmark traits of cancer. Nevertheless, the anticancer drugs available today are not efficient in treating patients with advanced-stage cancers and also exert quite serious side effects. One thing that clinicians and researchers have thoroughly understood so far is that highly specific drugs with only a single mechanism of action are not a prime choice. Thus, polypharmacologically active drugs with detailed knowledge about the genes and pathways that they modulate are what researchers and clinicians are presently looking for. Gene and pathway knowledge will also help us to understand the possible side effects of any drugs in advance since most genes are not specific to a particular location or responsible only for a particular disease. Most genes influence other genes as they are connected through the related pathways. Cheminformatics- and bioinformatics-based studies such as network-pharmacology-based studies, ADMET prediction, molecular docking, and molecular dynamics simulations are quite important in aiding and expediting research towards the translational level. Translational aspects of preclinical studies to clinical level are of utmost importance for natural products to progress from bench to bedside. |
| format | Online |
| id | doab-20.500.12854ir-174780 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2026 |
| publishDateRange | 2026 |
| publishDateSort | 2026 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1747802026-04-16T16:22:38Z Anticancer Drug Discovery Based on Natural Products Singla, Rajeev K. Bishayee, Anupam Leukemia Multiple myeloma DNA damage HDAC inhibitors Oxidative stress Chromatin remodeling Natural agents Lung cancer Phytochemicals Signaling pathways Preclinical Clinical studies Hepatocellular carcinoma Crocin Sorafenib Inflammation Apoptosis Drug repurposing Hematological malignancies Microtubules Programmed cell death Targeted chemotherapy Third-generation retinoid Xenograft tumor zebrafish model Diethylnitrosamine Acetylaminofluorene Naringin Naringin–dextrin nanocomposite Anticancer Anti-inflammatory Antioxidant Euphorbiaceae family In vitro In vivo Extracts Pure compounds Nanoparticles Natural products Plant-derived polyphenols Gnetin C Targeted therapeutics Anticancer effects MTA1 MTOR Advanced prostate cancer Polyphenols Anti-cancer Anti-oxidant Chemoprevention Gelatinases MMP NF-κB Bioactive triterpenoids Triple-negative breast cancer PI3 kinase inhibition Mitophagy Combination therapy Anticancer drugs Camptothecin derivatives Objective response Meta-analysis Combinational therapy N A thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Cancer is heterogeneous and dynamic in nature, and its drug resistance, due to high vulnerability to point mutations, and its aberrant pathways are making it quite challenging to efficiently address and manage. Natural products have always been a mainstream source of anticancer drugs due to the modulation of multiple hallmark traits of cancer. Nevertheless, the anticancer drugs available today are not efficient in treating patients with advanced-stage cancers and also exert quite serious side effects. One thing that clinicians and researchers have thoroughly understood so far is that highly specific drugs with only a single mechanism of action are not a prime choice. Thus, polypharmacologically active drugs with detailed knowledge about the genes and pathways that they modulate are what researchers and clinicians are presently looking for. Gene and pathway knowledge will also help us to understand the possible side effects of any drugs in advance since most genes are not specific to a particular location or responsible only for a particular disease. Most genes influence other genes as they are connected through the related pathways. Cheminformatics- and bioinformatics-based studies such as network-pharmacology-based studies, ADMET prediction, molecular docking, and molecular dynamics simulations are quite important in aiding and expediting research towards the translational level. Translational aspects of preclinical studies to clinical level are of utmost importance for natural products to progress from bench to bedside. 2026-04-16T16:22:28Z 2026-04-16T16:22:28Z 2025 book ONIX_20260416T142754_9783725852772_35 9783725852772 9783725852789 https://directory.doabooks.org/handle/20.500.12854/174780 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/ https://mdpi.com/books/pdfview/book/11659 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-5278-9 10.3390/books978-3-7258-5278-9 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725852772 9783725852789 320 CH open access |
| spellingShingle | Leukemia Multiple myeloma DNA damage HDAC inhibitors Oxidative stress Chromatin remodeling Natural agents Lung cancer Phytochemicals Signaling pathways Preclinical Clinical studies Hepatocellular carcinoma Crocin Sorafenib Inflammation Apoptosis Drug repurposing Hematological malignancies Microtubules Programmed cell death Targeted chemotherapy Third-generation retinoid Xenograft tumor zebrafish model Diethylnitrosamine Acetylaminofluorene Naringin Naringin–dextrin nanocomposite Anticancer Anti-inflammatory Antioxidant Euphorbiaceae family In vitro In vivo Extracts Pure compounds Nanoparticles Natural products Plant-derived polyphenols Gnetin C Targeted therapeutics Anticancer effects MTA1 MTOR Advanced prostate cancer Polyphenols Anti-cancer Anti-oxidant Chemoprevention Gelatinases MMP NF-κB Bioactive triterpenoids Triple-negative breast cancer PI3 kinase inhibition Mitophagy Combination therapy Anticancer drugs Camptothecin derivatives Objective response Meta-analysis Combinational therapy N A thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Anticancer Drug Discovery Based on Natural Products |
| title | Anticancer Drug Discovery Based on Natural Products |
| title_full | Anticancer Drug Discovery Based on Natural Products |
| title_fullStr | Anticancer Drug Discovery Based on Natural Products |
| title_full_unstemmed | Anticancer Drug Discovery Based on Natural Products |
| title_short | Anticancer Drug Discovery Based on Natural Products |
| title_sort | anticancer drug discovery based on natural products |
| topic | Leukemia Multiple myeloma DNA damage HDAC inhibitors Oxidative stress Chromatin remodeling Natural agents Lung cancer Phytochemicals Signaling pathways Preclinical Clinical studies Hepatocellular carcinoma Crocin Sorafenib Inflammation Apoptosis Drug repurposing Hematological malignancies Microtubules Programmed cell death Targeted chemotherapy Third-generation retinoid Xenograft tumor zebrafish model Diethylnitrosamine Acetylaminofluorene Naringin Naringin–dextrin nanocomposite Anticancer Anti-inflammatory Antioxidant Euphorbiaceae family In vitro In vivo Extracts Pure compounds Nanoparticles Natural products Plant-derived polyphenols Gnetin C Targeted therapeutics Anticancer effects MTA1 MTOR Advanced prostate cancer Polyphenols Anti-cancer Anti-oxidant Chemoprevention Gelatinases MMP NF-κB Bioactive triterpenoids Triple-negative breast cancer PI3 kinase inhibition Mitophagy Combination therapy Anticancer drugs Camptothecin derivatives Objective response Meta-analysis Combinational therapy N A thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| topic_facet | Leukemia Multiple myeloma DNA damage HDAC inhibitors Oxidative stress Chromatin remodeling Natural agents Lung cancer Phytochemicals Signaling pathways Preclinical Clinical studies Hepatocellular carcinoma Crocin Sorafenib Inflammation Apoptosis Drug repurposing Hematological malignancies Microtubules Programmed cell death Targeted chemotherapy Third-generation retinoid Xenograft tumor zebrafish model Diethylnitrosamine Acetylaminofluorene Naringin Naringin–dextrin nanocomposite Anticancer Anti-inflammatory Antioxidant Euphorbiaceae family In vitro In vivo Extracts Pure compounds Nanoparticles Natural products Plant-derived polyphenols Gnetin C Targeted therapeutics Anticancer effects MTA1 MTOR Advanced prostate cancer Polyphenols Anti-cancer Anti-oxidant Chemoprevention Gelatinases MMP NF-κB Bioactive triterpenoids Triple-negative breast cancer PI3 kinase inhibition Mitophagy Combination therapy Anticancer drugs Camptothecin derivatives Objective response Meta-analysis Combinational therapy N A thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| url | ONIX_20260416T142754_9783725852772_35 |