Liver Fibrosis
Fibrosis is a double-edged sword. On one hand, it can be the final stage of healed inflammation as scar tissue. On the other hand, it is often linked to a decrease in organ function or complete organ failure. Additionally, in liver disease, fibrosis serves as an indicator of disease progression towa...
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| Format: | Online |
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| Jezik: | engleski |
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MDPI - Multidisciplinary Digital Publishing Institute
2026
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| Online pristup: | ONIX_20260416T142754_9783725854417_5 |
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| collection | Directory of Open Access Books |
| description | Fibrosis is a double-edged sword. On one hand, it can be the final stage of healed inflammation as scar tissue. On the other hand, it is often linked to a decrease in organ function or complete organ failure. Additionally, in liver disease, fibrosis serves as an indicator of disease progression towards liver cirrhosis or hepatocellular carcinoma. This is particularly true for non-alcoholic fatty liver disease, a widespread disorder associated with Western lifestyles and diets. To interfere with organ fibrosis, it is crucial to have a better understanding of its initiation, perpetuation, and resolution at the molecular level. The development of liver fibrosis can be caused by metabolic factors (such as alcohol, diet, and drugs), infections (such as viruses), autoimmune conditions (like primary biliary cholangitis), or genetic abnormalities (such as increased iron storage). The molecular pathways that lead to advanced fibrosis vary depending on the underlying cause. The goal of this Special Issue is to dissect these processes and provide more clarity on the subject. |
| format | Online |
| id | doab-20.500.12854ir-174800 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2026 |
| publishDateRange | 2026 |
| publishDateSort | 2026 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1748002026-04-16T16:30:36Z Liver Fibrosis Weiskirchen, Ralf Sauerbruch, Tilman Fibrosis Hepatic stellate cells Portal hypertension Extracellular matrix Cytokines Chemokines Biomarkers NASH NAFLD Cirrhosis Hepatocellular carcinoma Therapy Animal models Imaging of hepatic fibrosis Biomarkers of hepatic fibrosis thema EDItEUR::M Medicine and Nursing Fibrosis is a double-edged sword. On one hand, it can be the final stage of healed inflammation as scar tissue. On the other hand, it is often linked to a decrease in organ function or complete organ failure. Additionally, in liver disease, fibrosis serves as an indicator of disease progression towards liver cirrhosis or hepatocellular carcinoma. This is particularly true for non-alcoholic fatty liver disease, a widespread disorder associated with Western lifestyles and diets. To interfere with organ fibrosis, it is crucial to have a better understanding of its initiation, perpetuation, and resolution at the molecular level. The development of liver fibrosis can be caused by metabolic factors (such as alcohol, diet, and drugs), infections (such as viruses), autoimmune conditions (like primary biliary cholangitis), or genetic abnormalities (such as increased iron storage). The molecular pathways that lead to advanced fibrosis vary depending on the underlying cause. The goal of this Special Issue is to dissect these processes and provide more clarity on the subject. 2026-04-16T16:30:31Z 2026-04-16T16:30:31Z 2025 book ONIX_20260416T142754_9783725854417_5 9783725854417 9783725854424 https://directory.doabooks.org/handle/20.500.12854/174800 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/ https://mdpi.com/books/pdfview/book/11679 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-5442-4 10.3390/books978-3-7258-5442-4 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725854417 9783725854424 228 CH open access |
| spellingShingle | Fibrosis Hepatic stellate cells Portal hypertension Extracellular matrix Cytokines Chemokines Biomarkers NASH NAFLD Cirrhosis Hepatocellular carcinoma Therapy Animal models Imaging of hepatic fibrosis Biomarkers of hepatic fibrosis thema EDItEUR::M Medicine and Nursing Liver Fibrosis |
| title | Liver Fibrosis |
| title_full | Liver Fibrosis |
| title_fullStr | Liver Fibrosis |
| title_full_unstemmed | Liver Fibrosis |
| title_short | Liver Fibrosis |
| title_sort | liver fibrosis |
| topic | Fibrosis Hepatic stellate cells Portal hypertension Extracellular matrix Cytokines Chemokines Biomarkers NASH NAFLD Cirrhosis Hepatocellular carcinoma Therapy Animal models Imaging of hepatic fibrosis Biomarkers of hepatic fibrosis thema EDItEUR::M Medicine and Nursing |
| topic_facet | Fibrosis Hepatic stellate cells Portal hypertension Extracellular matrix Cytokines Chemokines Biomarkers NASH NAFLD Cirrhosis Hepatocellular carcinoma Therapy Animal models Imaging of hepatic fibrosis Biomarkers of hepatic fibrosis thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20260416T142754_9783725854417_5 |